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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LRIG3, ROS1 (from a repository: Thu Nov 24 19:48:48 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins3 (18.75 %)
The number (and %) of the tumor suppressors3 (18.75 %)
Total number of binary PPIs (saturation %)22 (18.33 %)
The number (and %) of affected PPIs14 (63.64 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.125
Assortativity coefficient-0.7026
The network average Clustering coefficient0.237
The number (and %) of a zero Clustering coefficients11 (68.75 %)
The number (and %) of a zero Betweenness Centrality13 (81.25 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: ROS1,LRIG3 All fusions
: AB795248; AB795247;
Proteins found in more fusions GRB2 (see 1 fusions); PTPN11 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ROS1parental protein50.30011.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
2 LRIG3parental protein9072.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ig_3 (PF13927): Immunoglobulin domain
3 CAND1interactor200Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
4 GAL3ST1interactor100Rhabdo_M1 (PF03342, IPR005010): Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)
5 GINM1interactor100NA
6 GRB2oncoprotein50.5003.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
7 IKBKGinteractor200CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
8 LPAR6interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1
9 PTGER3interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
FtsX (PF02687, IPR003838): FtsX-like permease family
10 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
11 PTPN6suppressor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
12 PTPRKsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
13 PVRIGinteractor100NA
14 TAZinteractor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
15 TNFSF13Boncoprotein200TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
16 VAV3oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
DUF2326 (PF10088, IPR018760): Uncharacterised protein conserved in bacteria (DUF2326)
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
PH_10 (PF15411): Pleckstrin homology domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GINM1interactorNAAB795247, AB795248
2 LRIG3parental proteinI-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ig_3 (PF13927): Immunoglobulin domain
AB795247, AB795248
3 PVRIGinteractorNAAB795247, AB795248
4 ROS1parental proteinfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
AB795247, AB795248

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