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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LEPROTL1, BCL9 (from a repository: Sat Mar 4 06:50:59 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins3 (25.00 %)
The number (and %) of the tumor suppressors1 (8.33 %)
Total number of binary PPIs (saturation %)19 (28.79 %)
The number (and %) of affected PPIs11 (57.89 %)
The number of possible different fusions2
PPI diameter4
PPI radius2
The average degree of PPI2.667
Assortativity coefficient-0.4348
The network average Clustering coefficient0.325
The number (and %) of a zero Clustering coefficients6 (50.00 %)
The number (and %) of a zero Betweenness Centrality7 (58.33 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions EWSR1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LEPROTL1parental protein5056.333Vps55 (PF04133, IPR007262): Vacuolar protein sorting 55
2 BCL9parental protein60.26732.000ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
BCL9 (PF11502, IPR024670): B-cell lymphoma 9 protein
3 CTNNB1oncoprotein40.33316.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
4 EDAinteractor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
5 ELAVL1oncoprotein60.30047.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
7 KLRG1interactor100Gemini_mov (PF01708, IPR002621): Geminivirus putative movement protein
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
TMEM89 (PF15098, IPR028069): TMEM89 protein family
8 MSR1interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Macscav_rec (PF03523, IPR003543): Macrophage scavenger receptor
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
9 PYGO1interactor100PHD (PF00628, IPR019787, SM00249): PHD-finger
10 PYGO2interactor31.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
11 UNKinteractor206.667MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
12 WWOXsuppressor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain

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