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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RIT2, ADCY2 (from a repository: Tue Aug 20 16:46:22 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins9 (75.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)17 (25.76 %)
The number (and %) of affected PPIs10 (58.82 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI2.000
Assortativity coefficient-0.3536
The network average Clustering coefficient0.170
The number (and %) of a zero Clustering coefficients9 (75.00 %)
The number (and %) of a zero Betweenness Centrality8 (66.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ADCY2,RIT2 All fusions
Proteins found in more fusions APP (see 5 fusions); GNAS (see 5 fusions); LZTR1 (see 2 fusions); ADCY5 (see 1 fusions); SRPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ADCY2parental protein2020.000DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3487 (PF11990, IPR021877): Protein of unknown function (DUF3487)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
2 RIT2parental protein80.03696.000Ras (PF00071, IPR001806, SM00173): Ras family
3 ADCY5protein found in more fusions200DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3566 (PF12089, IPR021949): Transmembrane domain of unknown function (DUF3566)
DUF4191 (PF13829, IPR025445): Domain of unknown function (DUF4191)
HILPDA (PF15220, IPR026190): Hypoxia-inducible lipid droplet-associated
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
4 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 CALM1interactor2048.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
6 GNASoncoprotein3036.000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
7 LZTR1oncoprotein200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
8 POU4F1oncoprotein100Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Tic110 (PF16940, IPR031610): Chloroplast envelope transporter
9 RAB5Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
10 RLFoncoprotein100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
11 SOS1oncoprotein100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
12 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)

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