Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ACTB (from a repository: Mon Dec 5 13:21:29 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 223 The number (and %) of the onco-proteins 68 (30.49 %) The number (and %) of the tumor suppressors 36 (16.14 %) Total number of binary PPIs (saturation %) 2175 (8.79 %) The number (and %) of affected PPIs 223 (10.25 %) The number of possible different fusions 41 PPI diameter 2 PPI radius 1 The average degree of PPI 18.664 Assortativity coefficient -0.1898 The network average Clustering coefficient 0.479 The number (and %) of a zero Clustering coefficients 9 (4.04 %) The number (and %) of a zero Betweenness Centrality 30 (13.45 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ACTB	All fusions : BI019850; BG258572; CB219182;
Proteins found in more fusions	CUL1 (see 3 fusions); GRB2 (see 1 fusions); LGALS3BP (see 2 fusions); VHL (see 1 fusions); ACTB/ACTG1 (see 1 fusions); AIMP2 (see 1 fusions); EP300 (see 1 fusions); RPA1 (see 1 fusions); SNW1 (see 1 fusions); VCP (see 4 fusions); A2M (see 2 fusions); SRPK2 (see 1 fusions); ERBB3 (see 2 fusions); HNRNPD (see 1 fusions); POLR2A (see 2 fusions); SHC1 (see 1 fusions); ERRFI1 (see 1 fusions); TUBG1 (see 1 fusions); STAU1 (see 2 fusions); EPS15 (see 1 fusions); EEF1A1 (see 1 fusions); CBL (see 1 fusions); CUL3 (see 1 fusions); RAC1 (see 1 fusions); IVNS1ABP (see 2 fusions); MYC (see 1 fusions); KAT2B (see 1 fusions); ACTB (see 3 fusions); BCL2L1 (see 1 fusions); ACTG1 (see 4 fusions); ACTG1/MEPCE (see 1 fusions); SKI (see 1 fusions); COPS5 (see 1 fusions); LRRK2 (see 1 fusions); TP53 (see 3 fusions); AP2M1 (see 3 fusions); ENC1 (see 1 fusions); KHDRBS1 (see 1 fusions); KAT5 (see 3 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ACTB	parental protein	223	0.076	28937.125	Actin (PF00022, IPR004000, SM00268): Actin
2	A2M	protein found in more fusions	14	0.218	35.317	A2M (PF00207, IPR001599): Alpha-2-macroglobulin family A2M_comp (PF07678, IPR011626): A-macroglobulin complement component A2M_N (PF01835, IPR002890): MG2 domain A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region A2M_recep (PF07677, IPR009048): A-macroglobulin receptor MP (PF01107, IPR028919): Viral movement protein (MP) SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA) Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3	ABLIM1	interactor	9	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain VHP (PF02209, IPR003128, SM00153): Villin headpiece domain zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175) AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
4	ACD	interactor	5	0.600	3.400	TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
5	ACE	interactor	2	1.000	0	Peptidase_M2 (PF01401, IPR001548): Angiotensin-converting enzyme
6	ACTG1	protein found in more fusions	53	0.198	659.982	Actin (PF00022, IPR004000, SM00268): Actin
7	ACTR2	interactor	27	0.467	53.810	Actin (PF00022, IPR004000, SM00268): Actin
8	ACTR3	interactor	17	0.559	22.639	Actin (PF00022, IPR004000, SM00268): Actin
9	ADA	interactor	3	0.667	1.000	A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
10	AGO4	interactor	4	0.500	0.693	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
11	AIMP2	suppressor	8	0.619	2.114	GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
12	AKT1	oncoprotein	26	0.267	117.606	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
13	ALK	oncoprotein	7	0.619	3.870	MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
14	AMOT	oncoprotein	8	0.381	5.416	FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
15	ANGPTL4	suppressor	6	0.867	0.364	SlyX (PF04102, IPR007236): SlyX Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
16	ANXA7	suppressor	11	0.400	10.402	Annexin (PF00191, IPR018502, SM00335): Annexin
17	AP2M1	protein found in more fusions	25	0.446	47.657	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
18	AR	oncoprotein	26	0.257	105.765	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19	ARRB2	interactor	24	0.395	52.847	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
20	ASB12	interactor	3	0.667	0.286	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat SOCS_box (PF07525, IPR001496): SOCS box
21	ASB9	interactor	3	0.667	0.333	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
22	ATF3	suppressor	9	0.571	4.395	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
23	BBS4	interactor	4	0.667	0.733	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Mu-like_Pro (PF10123, IPR012106): Mu-like prophage I protein TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
24	BCL2L1	oncoprotein	9	0.571	2.932	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
25	BCL7C	suppressor	5	0.700	1.000	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
26	CAD	oncoprotein	24	0.315	67.456	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain GATase (PF00117, IPR017926): Glutamine amidotransferase class-I MGS (PF02142, IPR011607, SM00851): MGS-like domain OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
27	CAND1	interactor	38	0.371	149.551	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
28	CAP2	interactor	5	1.000	0	CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
29	CARM1	oncoprotein	16	0.542	14.707	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
30	CAV1	suppressor	14	0.330	28.835	Caveolin (PF01146, IPR001612): Caveolin
31	CBL	suppressor	19	0.451	39.184	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
32	CCT2	interactor	35	0.343	110.263	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
33	CCT5	interactor	28	0.336	84.927	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
34	CD81	interactor	17	0.300	36.486	Tetraspannin (PF00335, IPR018499): Tetraspanin family
35	CDC5L	interactor	47	0.307	259.993	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
36	CDK2	suppressor	56	0.294	382.595	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
37	CDKN1A	suppressor	25	0.363	78.121	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
38	CDKN2A	suppressor	20	0.400	38.433	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
39	CENPA	interactor	8	0.667	1.078	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
40	CEP250	interactor	14	0.363	21.306	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
41	CFL1	interactor	32	0.341	145.758	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
42	CFL2	interactor	16	0.610	19.487	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
43	COPS5	protein found in more fusions	34	0.498	53.318	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
44	COPS6	interactor	22	0.457	35.939	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
45	CORO1B	interactor	16	0.675	14.585	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_4 (PF16300): Type of WD40 repeat
46	CORO1C	oncoprotein	30	0.437	75.501	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WD40_4 (PF16300): Type of WD40 repeat
47	CORO7	interactor	4	0.667	0.583	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_4 (PF16300): Type of WD40 repeat
48	COTL1	oncoprotein	4	0.667	0.325	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
49	CRK	oncoprotein	23	0.316	83.479	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
50	CSNK2B	interactor	19	0.294	45.799	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
51	CTGF	suppressor	2	1.000	0	Cys_knot (PF00007, IPR006208): Cystine-knot domain VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
52	CUL1	suppressor	44	0.401	174.603	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
53	CUL2	suppressor	28	0.471	55.051	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
54	CUL3	protein found in more fusions	61	0.268	519.666	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
55	CUL5	suppressor	31	0.396	148.229	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
56	CYBB	interactor	2	1.000	0	FAD_binding_8 (PF08022, IPR013112): FAD-binding domain Ferric_reduct (PF01794, IPR013130): Ferric reductase like transmembrane component NAD_binding_6 (PF08030, IPR013121): Ferric reductase NAD binding domain
57	DAB2	suppressor	13	0.744	4.968	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
58	DHX9	oncoprotein	39	0.323	162.625	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
59	DMAP1	interactor	10	0.800	2.662	DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
60	DSTN	interactor	15	0.314	44.103	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
61	DTNA	interactor	2	1.000	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CRISPR_Cse2 (PF09485, IPR013382): CRISPR-associated protein Cse2 (CRISPR_cse2) EF-hand_2 (PF09068, IPR015153): EF hand EF-hand_3 (PF09069, IPR015154): EF-hand PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
62	DUSP19	interactor	2	1.000	0	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
63	EEF1A1	suppressor	69	0.166	960.106	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
64	EEF1A2	oncoprotein	25	0.283	79.687	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
65	EHHADH	interactor	3	0.667	0.667	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
66	EIF4A3	interactor	22	0.510	30.518	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
67	ELAVL1	oncoprotein	56	0.173	708.186	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
68	EMD	interactor	16	0.371	25.597	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
69	ENC1	oncoprotein	4	0.667	0.500	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain HTH_12 (PF08461, IPR013668): Ribonuclease R winged-helix domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
70	EP300	oncoprotein	31	0.317	138.014	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
71	EPS15	oncoprotein	18	0.529	20.392	Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
72	ERBB2	oncoprotein	13	0.470	17.645	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
73	ERBB3	oncoprotein	16	0.390	30.072	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
74	ERG	oncoprotein	11	0.491	5.707	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
75	ERRFI1	suppressor	10	0.611	4.511	GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
76	ESR1	suppressor	59	0.221	556.825	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
77	ESR2	suppressor	11	0.556	6.456	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
78	FABP4	interactor	2	1.000	0	Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
79	FBXO25	suppressor	17	0.338	30.383	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
80	FHOD1	interactor	10	0.389	8.963	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
81	FLNA	suppressor	53	0.285	421.754	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
82	FN1	oncoprotein	49	0.264	327.255	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
83	FPR1	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) Phage_holin_2_1 (PF04971, IPR007054): Bacteriophage P21 holin S
84	FUS	suppressor	40	0.409	133.847	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
85	GRB2	oncoprotein	47	0.268	354.782	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
86	H2AFX	suppressor	23	0.304	63.069	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
87	HAUS1	interactor	7	0.467	2.282	THP2 (PF09432, IPR018557): Tho complex subunit THP2 XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
88	HCK	oncoprotein	6	0.400	3.608	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
89	HDAC6	oncoprotein	20	0.205	64.662	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
90	HMMR	interactor	3	0.667	0.400	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family ApoO (PF09769, IPR019166): Apolipoprotein O Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
91	HNF1A	oncoprotein	5	0.667	0.417	HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
92	HNRNPA1	interactor	58	0.320	409.699	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
93	HNRNPD	oncoprotein	42	0.332	158.732	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
94	HNRNPU	interactor	64	0.241	608.990	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
95	HOMER1	interactor	3	1.000	0	WH1 (PF00568, IPR000697, SM00461): WH1 domain TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
96	HOXB5	interactor	3	0.667	0.333	DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
97	HSD17B3	interactor	1	0	0	adh_short (PF00106, IPR002198): short chain dehydrogenase
98	HSPA5	oncoprotein	65	0.247	627.118	HSP70 (PF00012, IPR013126): Hsp70 protein
99	HSPB2	interactor	8	0.381	5.577	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
100	ICAM1	oncoprotein	5	0.900	0.087	Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
101	ICAM3	interactor	1	0	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
102	INO80	interactor	4	1.000	0	Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain POTRA (PF07244, IPR010827): Surface antigen variable number repeat Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DBINO (PF13892, IPR020838): DNA-binding domain FAM176 (PF14851): FAM176 family MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
103	IQCB1	interactor	11	0.382	9.423	DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765) IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
104	IQGAP1	interactor	57	0.268	515.203	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
105	ISG15	suppressor	16	0.333	22.102	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
106	ITGA4	interactor	37	0.319	139.145	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
107	IVNS1ABP	protein found in more fusions	13	0.652	3.606	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
108	KAT2B	protein found in more fusions	22	0.367	76.564	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
109	KAT5	suppressor	23	0.394	62.035	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
110	KHDRBS1	protein found in more fusions	26	0.243	129.520	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
111	LGALS3BP	oncoprotein	25	0.409	52.511	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
112	LGR4	interactor	13	0.379	8.844	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
113	LIMA1	suppressor	33	0.422	94.230	LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
114	LMX1B	interactor	1	0	0	LIM (PF00412, IPR001781, SM00132): LIM domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
115	LRRK2	oncoprotein	15	0.396	27.561	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
116	MAGEA10	interactor	2	1.000	0	MAGE (PF01454, IPR002190): MAGE family SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
117	MAGOH	interactor	9	0.694	2.006	Mago_nashi (PF02792, IPR004023): Mago nashi protein
118	MAP1A	interactor	3	0.667	0.500	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) DUF572 (PF04502, IPR007590): Family of unknown function (DUF572) DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552) Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
119	MAP2	oncoprotein	5	0.667	0.515	MAP2_projctn (PF08377, IPR013588): MAP2/Tau projection domain Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat RII_binding_1 (PF10522, IPR018459): RII binding domain CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
120	MAPK7	oncoprotein	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
121	MDM2	oncoprotein	34	0.309	155.743	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
122	MEPCE	protein found in more fusions	14	0.505	9.860	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
123	MGMT	interactor	8	0.643	2.751	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
124	MKL1	oncoprotein	3	1.000	0	RPEL (PF02755, IPR004018, SM00707): RPEL repeat SAP (PF02037, IPR003034, SM00513): SAP domain Troponin-I_N (PF11636, IPR021666): Troponin I residues 1-32
125	MORF4L1	interactor	13	0.667	5.484	MRG (PF05712, IPR026541): MRG Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
126	MORF4L2	interactor	12	0.667	7.302	MRG (PF05712, IPR026541): MRG
127	MRGBP	interactor	10	0.778	1.862	Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
128	MYC	oncoprotein	35	0.346	133.799	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
129	MYH11	oncoprotein	14	0.275	22.922	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
130	MYH9	suppressor	61	0.261	585.008	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
131	MYO18A	interactor	27	0.484	72.362	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_tail_1 (PF01576, IPR002928): Myosin tail PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
132	MYOC	interactor	8	0.476	4.541	IncA (PF04156, IPR007285): IncA protein OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
133	NCALD	interactor	1	0	0	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
134	NCF1	interactor	4	0.667	0.333	p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain PX (PF00787, IPR001683, SM00312): PX domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
135	NEDD1	interactor	11	0.564	5.126	NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A FliM (PF02154, IPR001689): Flagellar motor switch protein FliM WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
136	NEDD8	interactor	23	0.576	33.548	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
137	NOS3	interactor	6	0.400	2.805	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
138	NSMAF	interactor	4	1.000	0	Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain GRAM (PF02893, IPR004182, SM00568): GRAM domain NABP (PF07990, IPR012940): Nucleic acid binding protein NABP WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
139	OSTF1	interactor	5	0.400	3.867	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
140	OTUB1	interactor	18	0.275	57.461	Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
141	PA2G4	interactor	14	0.374	21.514	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein
142	PAN2	interactor	29	0.337	86.985	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
143	PARK2	suppressor	28	0.293	113.023	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
144	PCK1	interactor	8	0.464	3.528	PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
145	PCYT1B	interactor	1	0	0	ApoC-I (PF04691, IPR006781): Apolipoprotein C-I (ApoC-1) CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
146	PFN1	suppressor	18	0.412	40.176	Profilin (PF00235, IPR005455, SM00392): Profilin
147	PHB	suppressor	17	0.353	32.035	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
148	PIK3R2	oncoprotein	19	0.515	26.229	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
149	PLG	interactor	4	0.667	0.508	Kringle (PF00051, IPR000001): Kringle domain PAN_1 (PF00024, IPR003014): PAN domain Trypsin (PF00089, IPR001254, SM00020): Trypsin
150	PNMA1	oncoprotein	4	0.500	2.667	PNMA (PF14893, IPR026523): PNMA
151	POLR1B	interactor	8	0.429	7.019	RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
152	POLR2A	protein found in more fusions	31	0.308	115.310	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
153	POT1	interactor	11	0.267	24.375	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
154	PPP1CA	suppressor	33	0.348	99.336	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
155	PPP1CB	interactor	35	0.360	144.015	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
156	PPP1CC	oncoprotein	30	0.451	64.150	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
157	PROM1	interactor	1	0	0	Prominin (PF05478, IPR008795): Prominin
158	PROSER2	interactor	2	1.000	0	SARG (PF15385): Specifically androgen-regulated gene protein
159	PRSS23	interactor	3	0.667	0.143	Trypsin (PF00089, IPR001254, SM00020): Trypsin
160	PSMA3	interactor	20	0.427	27.879	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
161	PSTPIP1	interactor	4	0.500	1.417	ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain WXG100 (PF06013, IPR010310): Proteins of 100 residues with WXG Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
162	RAB2A	oncoprotein	10	0.511	10.626	Ras (PF00071, IPR001806, SM00173): Ras family
163	RAB8B	oncoprotein	5	0.400	3.786	Ras (PF00071, IPR001806, SM00173): Ras family
164	RAC1	oncoprotein	16	0.438	20.213	Ras (PF00071, IPR001806, SM00173): Ras family
165	RAC2	oncoprotein	5	0.600	0.746	Ras (PF00071, IPR001806, SM00173): Ras family
166	RAD52	oncoprotein	8	0.667	1.809	Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
167	RCC1	interactor	7	0.524	2.179	RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
168	RPA1	suppressor	45	0.315	252.541	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
169	RPA2	oncoprotein	33	0.405	92.552	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
170	RPA3	interactor	32	0.383	87.261	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
171	RPL10A	interactor	21	0.448	21.218	Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
172	RUVBL1	oncoprotein	37	0.254	209.395	TIP49 (PF06068, IPR010339): TIP49 C-terminus
173	RUVBL2	oncoprotein	42	0.295	215.513	TIP49 (PF06068, IPR010339): TIP49 C-terminus
174	SAMHD1	interactor	11	0.511	5.796	HD (PF01966, IPR006674): HD domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
175	SCARNA22	interactor	9	0.639	1.960	NA
176	SHBG	oncoprotein	9	0.321	10.632	Laminin_G_1 (PF00054, IPR001791): Laminin G domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain
177	SHC1	oncoprotein	27	0.394	73.053	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
178	SKI	oncoprotein	10	0.639	2.723	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
179	SLC12A3	interactor	1	0	0	AA_permease (PF00324, IPR004841): Amino acid permease AA_permease_N (PF08403, IPR013612): Amino acid permease N-terminal SLC12 (PF03522, IPR018491): Solute carrier family 12
180	SLC30A6	interactor	2	1.000	0	Cation_efflux (PF01545, IPR002524): Cation efflux family
181	SLC6A2	interactor	2	1.000	0	SNF (PF00209, IPR000175): Sodium:neurotransmitter symporter family
182	SMAD3	oncoprotein	28	0.291	128.854	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
183	SMAD9	interactor	7	0.533	2.458	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
184	SMARCA4	suppressor	25	0.297	106.573	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
185	SMARCC2	interactor	17	0.390	34.541	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
186	SMARCE1	interactor	11	0.545	9.912	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
187	SMN1	interactor	16	0.390	25.612	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
188	SMURF1	interactor	20	0.474	16.474	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
189	SNCA	interactor	12	0.345	24.095	Synuclein (PF01387, IPR001058): Synuclein
190	SNW1	protein found in more fusions	43	0.319	221.199	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
191	SPTBN2	interactor	8	1.000	0	BEX (PF04538, IPR021156): Brain expressed X-linked like family CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Spectrin (PF00435, IPR002017): Spectrin repeat Mating_N (PF12731, IPR024333): Mating-type protein beta 1 DUF4110 (PF13422, IPR025183): Domain of unknown function (DUF4110) PH_9 (PF15410): Pleckstrin homology domain
192	SRPK2	oncoprotein	13	0.439	12.614	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
193	SSH1	interactor	3	0.667	0.400	DEK_C (PF08766, IPR014876): DEK C terminal domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
194	SSH2	interactor	9	0.833	0.999	DEK_C (PF08766, IPR014876): DEK C terminal domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
195	STAU1	protein found in more fusions	28	0.405	51.272	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
196	SVIL	interactor	16	0.575	22.761	Gelsolin (PF00626, IPR007123): Gelsolin repeat VHP (PF02209, IPR003128, SM00153): Villin headpiece domain DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
197	SYNPO	interactor	23	0.597	23.123	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
198	TAF11	interactor	3	1.000	0	CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X TAFII28 (PF04719, IPR006809): hTAFII28-like protein conserved region
199	TCP1	interactor	34	0.308	122.918	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
200	TINF2	interactor	6	0.600	3.400	TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
201	TJP1	interactor	8	0.464	11.673	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
202	TK1	oncoprotein	11	0.444	8.426	TK (PF00265, IPR001267, SM00203): Thymidine kinase
203	TP53	suppressor	58	0.244	545.420	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
204	TPST1	interactor	1	0	0	Sulfotransfer_3 (PF13469): Sulfotransferase family
205	TRAF3IP1	interactor	7	0.429	5.611	MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
206	TRIM15	suppressor	11	0.267	20.071	Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
207	TTR	interactor	5	0.500	0.715	Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
208	TUBG1	protein found in more fusions	27	0.363	85.058	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
209	TUBGCP2	interactor	13	0.423	16.658	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
210	TUBGCP3	interactor	13	0.628	6.467	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
211	UBASH3B	interactor	19	0.497	20.444	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
212	UBE3A	oncoprotein	12	0.436	15.135	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
213	UBL4A	interactor	16	0.350	27.643	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
214	UCHL5	oncoprotein	16	0.352	31.768	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
215	UNK	interactor	14	0.363	19.733	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
216	USP46	interactor	2	1.000	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
217	VCAM1	interactor	36	0.286	128.393	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
218	VCP	protein found in more fusions	48	0.268	344.292	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
219	VHL	suppressor	28	0.444	48.639	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
220	WDYHV1	interactor	6	0.333	6.586	Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
221	YARS	interactor	8	0.643	0.978	tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y) tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
222	YWHAQ	interactor	47	0.247	346.097	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
223	ZBTB1	interactor	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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