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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)120
The number (and %) of the onco-proteins37 (30.83 %)
The number (and %) of the tumor suppressors3 (2.50 %)
Total number of binary PPIs (saturation %)757 (10.60 %)
The number (and %) of affected PPIs119 (15.72 %)
The number of possible different fusions27
PPI diameter5
PPI radius3
The average degree of PPI11.867
Assortativity coefficient-0.2268
The network average Clustering coefficient0.501
The number (and %) of a zero Clustering coefficients14 (11.67 %)
The number (and %) of a zero Betweenness Centrality22 (18.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAGI2,RANGAP1 All fusions
Proteins found in more fusions PTBP1 (see 1 fusions); LMNA (see 4 fusions); EEF1G (see 1 fusions); U2AF2 (see 2 fusions); KPNB1 (see 2 fusions); CUL7 (see 2 fusions); HUWE1 (see 4 fusions); NCOA6 (see 1 fusions); RANGAP1 (see 2 fusions); NUP153 (see 2 fusions); PRPF8 (see 3 fusions); RANBP2 (see 1 fusions); EGFR (see 2 fusions); UBR5 (see 4 fusions); UBE2E3 (see 5 fusions); SORD (see 1 fusions); CSNK2A1 (see 2 fusions); ATN1 (see 1 fusions); NLK (see 4 fusions); PRDX6 (see 2 fusions); TPD52L2 (see 2 fusions); MIB1 (see 4 fusions); SENP1 (see 1 fusions); PCGF2 (see 1 fusions); NCL (see 4 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAGI2parental protein90964.790PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
2 RANGAP1parental protein1100.0987859.789RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
3 ACTR2interactor290.367159.583Actin (PF00022, IPR004000, SM00268): Actin
4 ACTR3interactor200.49547.797Actin (PF00022, IPR004000, SM00268): Actin
5 ACVR2Aoncoprotein100Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
6 ADGRB1interactor3027.4187tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
7 ADRB1interactor2027.4187tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 ARPC1Binteractor140.52720.349WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
9 ARPC2interactor170.55134.399P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
10 ARRB2interactor140.231732.255Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11 ARRDC3interactor2027.418Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
12 ATN1protein found in more fusions200Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
13 ATP6AP2interactor50.5002.942Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
14 BABAM1interactor31.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
15 BAG1oncoprotein80.6794.534BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
16 C11orf58interactor40.5001.150DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
17 CALUinteractor230.45164.131EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
18 CCL5interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
19 CDC5Linteractor250.40287.283OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
20 COL4A3BPinteractor31.0000Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
21 CPSF1interactor90.5567.801CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
22 CPSF4interactor40.6670.468zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-CCCH_3 (PF15663): Zinc-finger containing family
23 CSNK2A1oncoprotein160.41949.019Pkinase (PF00069, IPR000719): Protein kinase domain
24 CTNNB1oncoprotein130.321976.192Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
25 CUL7protein found in more fusions320.297401.373ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
26 DBNLinteractor40.6670.796RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 DSCAML1interactor100ChitinaseA_N (PF08329, IPR013540): Chitinase A, N-terminal domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
28 DYNC1LI1interactor40.8330.286DLIC (PF05783, IPR022780): Dynein light intermediate chain (DLIC)
29 EEF1Gprotein found in more fusions90.5367.869EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
30 EEF2Kinteractor80.6794.543Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
31 EFL1interactor130.62810.306EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
32 EFTUD2interactor150.52735.297EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
33 EGFRoncoprotein210.326146.223Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
34 FOXB1interactor80.35731.675Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
35 FOXE1oncoprotein30.6670.250Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
36 FOXJ3interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
37 FOXL1oncoprotein40.8330.250Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
38 FOXQ1interactor80.4647.767Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
39 GNAI1oncoprotein21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
40 GNAI3interactor50.6005.084G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
41 GNL1interactor31.0000HbrB (PF08539, IPR013745): HbrB-like
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
42 GTF3C3interactor80.39313.133BUD22 (PF09073, IPR015158): BUD22
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1
DUF3369 (PF11849, IPR021800): Domain of unknown function (DUF3369)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
TPR_20 (PF14561): Tetratricopeptide repeat
43 HUWE1oncoprotein190.359111.890BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
44 IPO11interactor120.47021.905DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
45 IPO5interactor150.52419.351HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
46 JUNoncoprotein60.5003.900bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
47 KDM2Ainteractor21.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
DZR (PF12773, IPR025874): Double zinc ribbon
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PHD_4 (PF16866, IPR019787): PHD-finger
48 KIF1BPinteractor160.56728.706TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
KBP_C (PF12309, IPR022083): KIF-1 binding protein C terminal
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
49 KPNB1protein found in more fusions300.369175.199Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
50 LMNAprotein found in more fusions180.45685.124Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
51 LPPoncoprotein130.32130.971LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
52 MEPCEinteractor80.6073.135Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
53 MIB1protein found in more fusions31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
54 MMS19interactor100.37815.533DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
55 MYO18Ainteractor50.8000.533Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
56 NCLprotein found in more fusions180.47143.276DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
57 NCOA6oncoprotein31.0000DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Presenilin (PF01080, IPR001108): Presenilin
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
58 NDUFA7interactor21.0000CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
59 NIF3L1interactor160.63814.056NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
60 NLKprotein found in more fusions50.66715.353Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
61 NSUN2interactor170.50067.346Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
62 NTRK1oncoprotein500.155876.331I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
63 NUP107interactor230.45861.654Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
64 NUP153protein found in more fusions240.470107.211Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
65 NUP35interactor100.7335.379Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
66 NUP85interactor120.60610.307Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
67 NXF1interactor340.241389.610NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
68 OBSL1interactor330.331198.516BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
69 OSGEPinteractor170.61714.658Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
70 PANK4interactor140.59315.696DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
71 PCF11interactor50.6001.439CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
CFIA_Pcf11 (PF11526, IPR021605): Subunit of cleavage factor IA Pcf11
72 PCGF2suppressor50.6670.571zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
73 PLXNB3interactor2074.436Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
Taeniidae_ag (PF05596, IPR008860): Taeniidae antigen
TIG (PF01833, IPR002909): IPT/TIG domain
74 PMS1oncoprotein70.6002.752DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
75 PNPT1interactor80.6792.338PNPase (PF03726, IPR015848): Polyribonucleotide nucleotidyltransferase, RNA binding domain
RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
76 POLR3Cinteractor30.6671.000HTH_9 (PF08221, IPR013197): RNA polymerase III subunit RPC82 helix-turn-helix domain
NIT (PF08376, IPR013587): Nitrate and nitrite sensing
RNA_pol_Rpc82 (PF05645, IPR008806): RNA polymerase III subunit RPC82
HD_4 (PF13328, IPR003607): HD domain
77 PPIBinteractor50.8000.250Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
78 PPIFinteractor100Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
79 PPP2R5Dinteractor90.5568.419B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
80 PRDX6protein found in more fusions60.5003.736AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
81 PRPF8oncoprotein180.52923.372PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
82 PTBP1oncoprotein130.50023.473RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
83 RALYinteractor150.47633.235RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
84 RANoncoprotein170.55129.571Ras (PF00071, IPR001806, SM00173): Ras family
85 RANBP2oncoprotein320.357248.613Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
86 RBPJinteractor50.5004.146BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
87 RCC1interactor170.45652.003RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
88 RGPD2interactor100GRIP (PF01465, IPR000237, SM00755): GRIP domain
HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Tropomyosin (PF00261, IPR000533): Tropomyosin
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Rab_bind (PF16704, IPR032023): Rab binding domain
89 RGPD5interactor31.0000GRIP (PF01465, IPR000237, SM00755): GRIP domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
FlxA (PF14282, IPR025577): FlxA-like protein
TPR_19 (PF14559): Tetratricopeptide repeat
Rab_bind (PF16704, IPR032023): Rab binding domain
90 RGPD6interactor100GRIP (PF01465, IPR000237, SM00755): GRIP domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
FlxA (PF14282, IPR025577): FlxA-like protein
TPR_19 (PF14559): Tetratricopeptide repeat
Rab_bind (PF16704, IPR032023): Rab binding domain
91 RNF2interactor200.31664.226zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
92 RPRD1Binteractor140.45127.508CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
93 SAE1interactor110.49113.806ThiF (PF00899, IPR000594): ThiF family
94 SCARNA22interactor60.6002.498NA
95 SEH1Linteractor120.7583.865WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
96 SENP1protein found in more fusions90.71410.519Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
97 SENP2interactor41.0000Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
98 SH3GLB1suppressor150.61514.395BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
99 SIRT7interactor250.34783.707DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
100 SNW1protein found in more fusions270.360123.802SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
101 SORDprotein found in more fusions31.0000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
102 SOX2oncoprotein140.26970.110HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
103 SUB1interactor70.4675.863Dehydrin (PF00257, IPR000167): Dehydrin
PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
104 SUMO1interactor200.35183.562Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
105 SUPT5Hinteractor130.46218.040KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
106 THG1Linteractor100.7502.609Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
107 TMUB1interactor21.0000DUF347 (PF03988, IPR007136): Repeat of Unknown Function (DUF347)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF4227 (PF14004, IPR025321): Protein of unknown function (DUF4227)
108 TOPORSsuppressor31.0000Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
109 TP53RKoncoprotein170.61017.466APH (PF01636, IPR002575): Phosphotransferase enzyme family
Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
110 TPD52L2protein found in more fusions190.51031.981TPD52 (PF04201, IPR007327): Tumour protein D52 family
111 TPRKBinteractor160.58321.748CGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
112 TTBK1interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
Pkinase (PF00069, IPR000719): Protein kinase domain
RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
113 U2AF2protein found in more fusions190.54924.106RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
114 UBE2E3protein found in more fusions50.5001.733UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
115 UBE2Iinteractor230.338110.535UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
116 UBR4interactor60.4002.886CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
RecR (PF02132, IPR023628): RecR protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
DZR (PF12773, IPR025874): Double zinc ribbon
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
FAM176 (PF14851): FAM176 family
117 UBR5protein found in more fusions90.39318.077CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
118 UFM1interactor90.6678.155Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
119 USPL1interactor40.5001.222zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
Peptidase_C98 (PF15499, IPR028890): Ubiquitin-specific peptidase-like, SUMO isopeptidase
DUF4650 (PF15509, IPR029388): Domain of unknown function (DUF4650)
120 XPO1interactor320.250382.997CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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