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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)62
The number (and %) of the onco-proteins11 (17.74 %)
The number (and %) of the tumor suppressors5 (8.06 %)
Total number of binary PPIs (saturation %)192 (10.15 %)
The number (and %) of affected PPIs60 (31.25 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI5.613
Assortativity coefficient-0.1340
The network average Clustering coefficient0.414
The number (and %) of a zero Clustering coefficients16 (25.81 %)
The number (and %) of a zero Betweenness Centrality24 (38.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RAB27A,AP3D1 All fusions
Proteins found in more fusions NIN (see 1 fusions); APP (see 5 fusions); GRK5 (see 2 fusions); STAU1 (see 2 fusions); VPS39 (see 1 fusions); ZBTB16 (see 4 fusions); EEF1A1 (see 6 fusions); COPG1 (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAB27Aparental protein230.0241662.419Ras (PF00071, IPR001806, SM00173): Ras family
2 AP3D1parental protein370.1291078.939Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
AP3D1 (PF06375): AP-3 complex subunit delta-1
3 ADRB2interactor50.50090.7477tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AGO3interactor60.66734.434ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
5 AP3B1interactor140.39648.172Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
6 AP3B2interactor60.5336.532Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal
7 AP3M1interactor140.38576.530Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
8 AP3S1interactor120.42438.014Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
9 AP3S2interactor60.7334.499Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
10 APPprotein found in more fusions70.067260.987APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
11 ARRB1interactor50.7001.297Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
12 ARRB2interactor120.303139.475Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
13 C14orf1interactor100Erg28 (PF03694, IPR005352): Erg28 like protein
14 CDC73suppressor50.9000.432CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
15 CDK11Boncoprotein41.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
16 CENPJinteractor30.6670.611DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein
Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
AAA_23 (PF13476): AAA domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
17 CEP126interactor100Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
18 CEP19interactor21.0000CEP19 (PF14933, IPR029412): CEP19-like protein
19 CLTBinteractor60.5338.809Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
20 CLTConcoprotein90.33393.803Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
21 COPG1protein found in more fusions60.6003.138Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
22 COPS6interactor50.167145.646DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
23 DAP3interactor31.0000DAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
24 DTNBP1interactor90.444103.250Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
25 EEF1A1suppressor120.164507.453GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
26 EGFRoncoprotein120.327160.091Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
27 EPB41L3suppressor60.53337.6234_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
28 EXPH5interactor100FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
29 F2Rinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF412 (PF04217, IPR007334): Protein of unknown function, DUF412
30 FBXO6interactor60.200147.783FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
31 FBXW7suppressor4033.475Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
32 GDF9interactor100CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
33 GRK5protein found in more fusions50.50023.664Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
34 HTATSF1interactor30.6670.517BUD22 (PF09073, IPR015158): BUD22
Conotoxin (PF02950, IPR004214): Conotoxin
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
35 KLC2interactor50.30055.130TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
36 LRIF1interactor200LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
37 MLPHinteractor21.0000Dpy-30 (PF05186, IPR007858): Dpy-30 motif
Rab_eff_C (PF04698, IPR006788): Rab effector MyRIP/melanophilin C-terminus
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
38 MYO5Ainteractor50.100294.124DIL (PF01843, IPR018444, SM01132): DIL domain
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SOGA (PF11365, IPR027881): Protein SOGA
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
CYTL1 (PF15153, IPR029253): Cytokine-like protein 1
39 MYRIPinteractor100Rab_eff_C (PF04698, IPR006788): Rab effector MyRIP/melanophilin C-terminus
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
40 NINoncoprotein200BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
41 NTRK1oncoprotein230.156633.376I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
42 POU5F1oncoprotein50.50022.367Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
43 RBM25interactor40.8331.117Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4778 (PF16008, IPR031958): Domain of unknown function (DUF4778)
44 RBM48interactor100DUF2284 (PF10050, IPR019271): Predicted metal-binding protein (DUF2284)
45 RNF13interactor30.6670.333DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
46 RPH3ALinteractor21.0000FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
47 RUFY1interactor70.6003.432DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
48 STAU1protein found in more fusions90.35759.894dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
49 SYTL1interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
50 SYTL2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
MSC (PF09402, IPR018996): Man1-Src1p-C-terminal domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
51 SYTL3interactor100BESS (PF02944, IPR004210): BESS motif
C2 (PF00168, IPR000008, SM00239): C2 domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
52 SYTL4interactor100AreA_N (PF07573, IPR011420): Nitrogen regulatory protein AreA N terminus
C2 (PF00168, IPR000008, SM00239): C2 domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
53 SYTL5interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
54 UNC13Binteractor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
Membr_traf_MHD (PF10540, IPR019558): Munc13 (mammalian uncoordinated) homology domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
55 UNC13Dinteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
Membr_traf_MHD (PF10540, IPR019558): Munc13 (mammalian uncoordinated) homology domain
56 VAMP7interactor21.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
57 VPS33Ainteractor40.6672.887Sec1 (PF00995, IPR001619): Sec1 family
58 VPS33Binteractor50.50023.720Sec1 (PF00995, IPR001619): Sec1 family
59 VPS39protein found in more fusions31.0000CNH (PF00780, IPR001180, SM00036): CNH domain
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
60 VPS41interactor50.60029.224Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
61 XPO1interactor130.47430.058CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
62 ZBTB16suppressor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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