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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)129
The number (and %) of the onco-proteins32 (24.81 %)
The number (and %) of the tumor suppressors13 (10.08 %)
Total number of binary PPIs (saturation %)796 (9.64 %)
The number (and %) of affected PPIs127 (15.95 %)
The number of possible different fusions22
PPI diameter5
PPI radius3
The average degree of PPI11.535
Assortativity coefficient-0.2036
The network average Clustering coefficient0.468
The number (and %) of a zero Clustering coefficients18 (13.95 %)
The number (and %) of a zero Betweenness Centrality26 (20.16 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions EXOC5 (see 1 fusions); CUL4A (see 4 fusions); PRMT5 (see 2 fusions); L3MBTL3 (see 1 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); CUL1 (see 3 fusions); WDR77 (see 1 fusions); CUL3 (see 1 fusions); SRPK2 (see 1 fusions); RBPMS (see 2 fusions); RABEP1 (see 1 fusions); CD2AP (see 1 fusions); SART3 (see 2 fusions); SNRNP200 (see 3 fusions); PRPF8 (see 3 fusions); BAG3 (see 4 fusions); COPS5 (see 1 fusions); HCFC1 (see 2 fusions); RAB11FIP1 (see 2 fusions); RPA1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RAB4Aparental protein290.0542628.801Ras (PF00071, IPR001806, SM00173): Ras family
2 SNRPBparental protein980.1126963.602LSM (PF01423, IPR001163): LSM domain
3 ADARinteractor90.5007.360dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
z-alpha (PF02295, IPR000607, SM00550): Adenosine deaminase z-alpha domain
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
4 AIREinteractor41.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain; Sp100 domain
zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
5 ASCC2interactor21.0000CUE (PF02845, IPR003892, SM00546): CUE domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
6 BAG3oncoprotein80.333123.142BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
7 BANPsuppressor60.30040.076DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
8 BARD1suppressor140.244241.221BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
9 C14orf1interactor21.0000Erg28 (PF03694, IPR005352): Erg28 like protein
10 CALCOCO2interactor41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
11 CAND1interactor270.47786.078Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
12 CD2APprotein found in more fusions40.66716.676SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
13 CD2BP2interactor70.7625.420GYF (PF02213, IPR003169, SM00444): GYF domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
14 CD81interactor60.7000.872Tetraspannin (PF00335, IPR018499): Tetraspanin family
15 CDKN2Asuppressor70.38125.261Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
16 CEP55interactor40.33311.814DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
17 CLNS1Ainteractor170.50052.338Voldacs (PF03517): Regulator of volume decrease after cellular swelling
18 COILinteractor70.5333.674CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
19 COPS5protein found in more fusions260.433151.995JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
20 CUL1suppressor180.56625.195Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21 CUL2suppressor160.69229.089Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22 CUL3protein found in more fusions410.324508.732Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
23 CUL4Aprotein found in more fusions150.69232.512Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL4Boncoprotein170.610132.040Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
25 CUL5suppressor200.568133.972Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26 CUL7protein found in more fusions220.395263.976ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
27 DAB1interactor206.597PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
28 DCUN1D1interactor160.78387.938Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
29 DDX20interactor150.49532.006DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
30 DYNC1H1interactor120.333164.091AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
31 DYNC1LI1interactor30.33395.585DLIC (PF05783, IPR022780): Dynein light intermediate chain (DLIC)
32 EFTUD2interactor310.343226.877EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
33 EIF4A3interactor230.53752.329DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34 EPB41L3suppressor100.57812.4204_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
35 EREGinteractor2036.677CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
EGF (PF00008, IPR000742, SM00181): EGF-like domain
36 EXOC5protein found in more fusions3027.118Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
37 EXOSC8interactor80.66710.904RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
38 FN1oncoprotein220.342398.027fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39 FNBP4oncoprotein100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pap_E4 (PF02711, IPR003861): E4 protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
WW (PF00397, IPR001202, SM00456): WW domain
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
40 GDI1interactor40.33387.453GDI (PF00996, IPR018203): GDP dissociation inhibitor
41 GDI2interactor70.333116.133GDI (PF00996, IPR018203): GDP dissociation inhibitor
42 GEMIN4interactor120.38235.635NA
43 GOLGA2interactor60.40015.257ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
44 GRIPAP1interactor100DivIC (PF04977, IPR007060): Septum formation initiator
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
JAKMIP_CC3 (PF16034, IPR031994): JAKMIP CC3 domain
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
45 HACE1suppressor200HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
46 HCFC1protein found in more fusions60.9000.356fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
47 HTATSF1interactor90.63910.820BUD22 (PF09073, IPR015158): BUD22
Conotoxin (PF02950, IPR004214): Conotoxin
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
48 HUWE1oncoprotein230.260745.225BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
49 ICAM1oncoprotein70.6673.540Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
50 IDH3Ainteractor3030.862Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
51 IFIT1interactor90.8890.434TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
DUF4268 (PF14088, IPR025364): Domain of unknown function (DUF4268)
TPR_19 (PF14559): Tetratricopeptide repeat
52 IFIT2interactor90.8890.434TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
HTH_WhiA (PF02650, IPR023054): WhiA C-terminal HTH domain
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Mad3_BUB1_I_2 (PF17014, IPR031522): Putative Mad3/BUB1 like region 1 protein
53 IFIT3interactor100.8890.434TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
54 IGSF8oncoprotein70.7143.734V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
55 IL7Rinteractor51.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
56 KCNA5interactor31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
57 KHKinteractor30.6670.464PfkB (PF00294, IPR011611): pfkB family carbohydrate kinase
58 KIF3Binteractor21.0000DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
59 KRT40interactor30.3337.109Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
60 L3MBTL3protein found in more fusions31.0000CDC45 (PF02724, IPR003874): CDC45-like protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Glyco_hydro_2_N (PF02837, IPR006104): Glycosyl hydrolases family 2, sugar binding domain
MBT (PF02820, IPR004092, SM00561): mbt repeat
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
Calci_bind_CcbP (PF11535, IPR020994): Calcium binding
Apelin (PF15360, IPR026155): APJ endogenous ligand
61 LGALS1interactor60.400168.397Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
62 LIN28Ainteractor40.5001.065CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-CCHC_6 (PF15288): Zinc knuckle
63 LSM2interactor140.46237.259LSM (PF01423, IPR001163): LSM domain
64 LSM8interactor80.4297.813LSM (PF01423, IPR001163): LSM domain
65 MAGOHinteractor170.52931.763Mago_nashi (PF02792, IPR004023): Mago nashi protein
66 MDC1suppressor120.40929.191FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
67 MEPCEinteractor130.56423.045Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
68 NANOGinteractor60.6004.190Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
69 NCS1interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
70 NLRP3oncoprotein100NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
71 NOS2interactor90.46413.068FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
72 OBSL1interactor200.48071.005BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
73 PAN2interactor130.56421.971RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
74 PIN1suppressor130.154497.466Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
75 PNMA1oncoprotein30163.497PNMA (PF14893, IPR026523): PNMA
76 PRAMEinteractor31.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
77 PRKCIinteractor2022.517PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
78 PRMT5protein found in more fusions190.49055.042PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
79 PRMT7interactor100Cons_hypoth95 (PF03602, IPR004398): Conserved hypothetical protein 95
PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
80 PRPF4Boncoprotein100.6228.776Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
Ureide_permease (PF07168, IPR009834): Ureide permease
Pkinase (PF00069, IPR000719): Protein kinase domain
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
81 PRPF8oncoprotein310.386287.267PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
82 PSMA3interactor120.273147.902Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
83 PTTG1IPoncoprotein21.0000DAP10 (PF07213, IPR009861): DAP10 membrane protein
IncA (PF04156, IPR007285): IncA protein
84 RAB11FIP1protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
SOUL (PF04832, IPR006917): SOUL heme-binding protein
Latarcin (PF10279, IPR018802): Latarcin precursor
85 RAB5Aoncoprotein120.258143.659Ras (PF00071, IPR001806, SM00173): Ras family
86 RAB7Asuppressor110.291402.567Ras (PF00071, IPR001806, SM00173): Ras family
87 RABEP1oncoprotein60.50051.327Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
88 RABEP2interactor60.400124.284Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
89 RABGAP1interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
90 RBPMSprotein found in more fusions50.33311.204RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
91 RBSNinteractor21.0000DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Histone_HNS (PF00816, IPR001801): H-NS histone family
zf-AD (PF07776, IPR012934, SM00868): Zinc-finger associated domain (zf-AD)
Rbsn (PF11464, IPR021565): Rabenosyn Rab binding domain
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
92 RFX6interactor31.0000RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
93 RPA1suppressor200.345210.115Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
94 RPA2oncoprotein200.358201.190RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
95 RPA3interactor150.48477.800Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
96 RPS6KB2interactor40.6670.917Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
97 RUFY1interactor60.300124.808DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
98 SART3protein found in more fusions150.286182.284CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
Lsm_interact (PF05391, IPR008669): Lsm interaction motif
Phage_GPD (PF05954): Phage late control gene D protein (GPD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
MRI (PF15325, IPR028278): Modulator of retrovirus infection
LSM_int_assoc (PF16605): LSM-interacting associated unstructured
99 SCCPDHinteractor100Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
100 SF3A2interactor200.54799.687Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
zf-met (PF12874): Zinc-finger of C2H2 type
ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
101 SF3A3interactor180.464104.016DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449)
SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
102 SKIV2Linteractor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3516 (PF12029, IPR021904): Domain of unknown function (DUF3516)
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
103 SMN1interactor200.392133.351SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
104 SMN2interactor120.6559.093SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
105 SMURF1interactor130.48592.036C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
106 SNRNP200protein found in more fusions340.402209.524DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
107 SNRPA1interactor280.378160.804LRR_9 (PF14580): Leucine-rich repeat
108 SNRPCinteractor280.265235.513zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
109 SNRPD1interactor440.300371.708API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
LSM (PF01423, IPR001163): LSM domain
110 SNRPD2interactor360.375175.552LSM (PF01423, IPR001163): LSM domain
111 SNRPD3interactor460.311589.111LSM (PF01423, IPR001163): LSM domain
112 SNRPEinteractor320.401152.322LSM (PF01423, IPR001163): LSM domain
113 SNUPNinteractor50.9000.286mRNA_cap_enzyme (PF01331, IPR001339): mRNA capping enzyme, catalytic domain
Snurportin1 (PF11538, IPR024721): Snurportin1
114 SRPK2oncoprotein170.358306.552DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
115 SRPK3interactor60.6671.514Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pkinase (PF00069, IPR000719): Protein kinase domain
116 SRRM1interactor220.455139.697DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen
MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family)
PWI (PF01480, IPR002483, SM00311): PWI domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
117 SS18L1oncoprotein50.8331.371DUF1313 (PF07011, IPR009741): Protein of unknown function (DUF1313)
SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
118 STX4oncoprotein50.16760.481Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
119 TFIP11interactor205.218G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal
120 TOP3Binteractor21.0000Topoisom_bac (PF01131, IPR013497): DNA topoisomerase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
121 TP53suppressor250.1671232.159DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
122 TRIM23interactor200Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
123 UPF1interactor110.41821.921UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
124 USP9Xinteractor130.38543.022DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
125 VPS52interactor31.0000Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
126 WBP4interactor50.7000.887CDC45 (PF02724, IPR003874): CDC45-like protein
WW (PF00397, IPR001202, SM00456): WW domain
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
TMCO5 (PF14992, IPR026617): TMCO5 family
127 WDR77oncoprotein170.59239.409LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
128 ZFYVE28interactor31.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
CK2S (PF15011, IPR029159): Casein Kinase 2 substrate
129 ZNF830interactor40.333121.073Sec34 (PF04136, IPR007265): Sec34-like family
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding

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