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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RAB3IL1, CD69 (from a repository: Wed Jul 24 05:56:52 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins6 (21.43 %)
The number (and %) of the tumor suppressors1 (3.57 %)
Total number of binary PPIs (saturation %)41 (10.85 %)
The number (and %) of affected PPIs27 (65.85 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.357
Assortativity coefficient-0.4927
The network average Clustering coefficient0.316
The number (and %) of a zero Clustering coefficients17 (60.71 %)
The number (and %) of a zero Betweenness Centrality24 (85.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CD69,RAB3IL1 All fusions
Proteins found in more fusions OPTN (see 1 fusions); MAP3K1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CD69parental protein100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
2 RAB3IL1parental protein260.023581.000Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
3 AMOToncoprotein31.0000FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
4 AMOTL1interactor21.0000NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Presenilin (PF01080, IPR001108): Presenilin
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
5 ATG4Cinteractor100Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
6 CCDC102Ainteractor21.0000IncA (PF04156, IPR007285): IncA protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
THOC7 (PF05615, IPR008501): Tho complex subunit 7
Uds1 (PF15456, IPR029191): Up-regulated During Septation
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
7 CCDC57interactor200CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Fez1 (PF06818): Fez1
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
SlyX (PF04102, IPR007236): SlyX
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF3983 (PF13137, IPR025041): Protein of unknown function (DUF3983)
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
8 EIF1AXoncoprotein100eIF-1a (PF01176, IPR006196): Translation initiation factor 1A / IF-1
9 EXOC8interactor100K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Vps51 (PF08700): Vps51/Vps67
Syntaxin_2 (PF14523): Syntaxin-like protein
Exo84_C (PF16528, IPR032403): Exocyst component 84 C-terminal
10 IP6K1interactor100IPK (PF03770, IPR005522): Inositol polyphosphate kinase
SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
11 KRT40interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
12 MAP3K1oncoprotein31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
13 MTUS2suppressor200DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
14 NOTCH2NLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
15 NUDT18interactor100NUDIX (PF00293, IPR000086): NUDIX domain
16 ODF2interactor40.5003.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase
Invasin_D3 (PF09134, IPR015217): Invasin, domain 3
Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
17 OPTNprotein found in more fusions40.6671.000ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
18 PPFIA3interactor200DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
T2SSF (PF00482, IPR018076): Type II secretion system (T2SS), protein F
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Tup_N (PF08581, IPR013890): Tup N-terminal
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
FAM76 (PF16046, IPR032017): FAM76 protein
19 PPIL4interactor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
20 PSMA3interactor200Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
21 RAB11Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
22 RAB3IPinteractor21.0000Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
23 RAB8Aoncoprotein30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
24 SATB2interactor100CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
25 SUGP2interactor100G-patch (PF01585, IPR000467, SM00443): G-patch domain
Surp (PF01805, IPR000061, SM00648): Surp module
26 TIGD7interactor100CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease
Mga (PF05043, IPR007737): Mga helix-turn-helix domain
HTH_Tnp_1 (PF01527, IPR002514): Transposase
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
27 TMEM102interactor100Mab-21 (PF03281, IPR024810): Mab-21 protein
28 TMEM190interactor100TMEM190 (PF15431, IPR028248): Transmembrane protein 190

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