Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PYGB (from a repository: Sun Dec 4 20:07:31 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 39 The number (and %) of the onco-proteins 8 (20.51 %) The number (and %) of the tumor suppressors 5 (12.82 %) Total number of binary PPIs (saturation %) 110 (14.84 %) The number (and %) of affected PPIs 39 (35.45 %) The number of possible different fusions 8 PPI diameter 2 PPI radius 1 The average degree of PPI 5.077 Assortativity coefficient -0.3724 The network average Clustering coefficient 0.568 The number (and %) of a zero Clustering coefficients 7 (17.95 %) The number (and %) of a zero Betweenness Centrality 16 (41.03 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PYGB	All fusions
Proteins found in more fusions	PFKL (see 2 fusions); ACTN1 (see 3 fusions); PYGB (see 1 fusions); MCM2 (see 1 fusions); SKI (see 1 fusions); SIAH1 (see 4 fusions); NPM1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PYGB	parental protein	39	0.087	1064.767	Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
2	ACLY	interactor	5	0.700	1.400	ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain Ligase_CoA (PF00549, IPR005811): CoA-ligase Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
3	ACTN1	protein found in more fusions	6	0.800	0.733	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
4	ARL6IP6	interactor	1	0	0	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix
5	ARMT1	interactor	2	1.000	0	DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
6	CAND1	interactor	6	0.900	0.400	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7	CCNL2	interactor	1	0	0	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
8	CPNE1	interactor	2	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain Copine (PF07002, IPR010734): Copine
9	CYP1A1	oncoprotein	2	1.000	0	p450 (PF00067, IPR001128): Cytochrome P450
10	FH	suppressor	6	0.533	6.000	Lyase_1 (PF00206, IPR022761): Lyase FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
11	FSD1	interactor	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SPRY (PF00622, IPR003877, SM00449): SPRY domain PLAC9 (PF15205, IPR027941): Placenta-specific protein 9 DUF4945 (PF16303, IPR032544): Domain of unknown function (DUF4945) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12	GBE1	interactor	2	1.000	0	Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain CBM_48 (PF02922, IPR004193): Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C (PF02806, IPR006048, SM00632): Alpha amylase, C-terminal all-beta domain
13	HSD17B3	interactor	1	0	0	adh_short (PF00106, IPR002198): short chain dehydrogenase
14	LIMD1	suppressor	5	0.667	1.333	LIM (PF00412, IPR001781, SM00132): LIM domain
15	LIN37	interactor	1	0	0	LIN37 (PF15306, IPR028226): LIN37
16	MCM2	oncoprotein	12	0.364	28.967	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
17	MCM5	oncoprotein	7	0.667	3.133	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
18	MLH1	suppressor	3	0.667	0.500	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
19	NAXE	interactor	2	1.000	0	YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
20	NPM1	suppressor	9	0.464	10.300	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
21	NTF3	interactor	3	0.667	0.333	NGF (PF00243, IPR002072, SM00140): Nerve growth factor family
22	NTRK1	oncoprotein	18	0.213	97.700	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
23	OGFOD1	interactor	5	0.600	3.000	Ofd1_CTDD (PF10637, IPR019601): Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 (PF13661): 2OG-Fe(II) oxygenase superfamily
24	PFKL	protein found in more fusions	4	0.667	0.333	PFK (PF00365, IPR000023): Phosphofructokinase
25	PLCG1	oncoprotein	7	0.476	9.833	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
26	PSMB2	interactor	2	1.000	0	Proteasome (PF00227, IPR001353): Proteasome subunit
27	PYGL	interactor	12	0.273	35.233	Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
28	RIC8A	interactor	4	0.833	0.500	PUL (PF08324, IPR013535): PUL domain Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
29	SENP3	interactor	5	0.700	1.233	Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis) Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
30	SIAH1	suppressor	4	1.000	0	Sina (PF03145, IPR018121): Seven in absentia protein family
31	SIRT7	interactor	7	0.429	7.633	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
32	SKI	oncoprotein	2	0	0	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
33	STBD1	interactor	1	0	0	CBM_20 (PF00686, IPR002044): Starch binding domain
34	TMEM185A	interactor	1	0	0	Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
35	UBA6	interactor	5	0.500	4.000	ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
36	UBR7	interactor	5	0.600	3.667	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
37	WDR61	interactor	4	0.667	1.333	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
38	XPNPEP1	interactor	4	0.667	1.667	Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24 Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
39	ZFP41	interactor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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