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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LETM1, PTPRZ1 (from a repository: Sat Aug 10 05:18:18 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins9 (39.13 %)
The number (and %) of the tumor suppressors1 (4.35 %)
Total number of binary PPIs (saturation %)45 (17.79 %)
The number (and %) of affected PPIs21 (46.67 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI3.043
Assortativity coefficient0.0599
The network average Clustering coefficient0.384
The number (and %) of a zero Clustering coefficients9 (39.13 %)
The number (and %) of a zero Betweenness Centrality13 (56.52 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LETM1,PTPRZ1 All fusions
Proteins found in more fusions LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LETM1parental protein130.115248.048DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
LETM1 (PF07766, IPR011685): LETM1-like protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Acetyltransf_11 (PF13720, IPR029098): Udp N-acetylglucosamine O-acyltransferase; Domain 2
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
2 PTPRZ1parental protein80.036164.000Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
3 C12orf57interactor100P_C10 (PF14974, IPR026317): Protein C10
4 C15orf48interactor21.0000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
5 CNTN1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
Ig_3 (PF13927): Immunoglobulin domain
6 COQ9interactor40.6671.000COQ9 (PF08511, IPR013718): COQ9
7 CTNNB1oncoprotein40.16798.286Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
8 CYP1A1oncoprotein100p450 (PF00067, IPR001128): Cytochrome P450
9 GIT1interactor3036.190ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
10 HMGB1oncoprotein2036.190HMG_box_2 (PF09011, IPR009071): HMG-box domain
NOA36 (PF06524, IPR010531): NOA36 protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
11 ILF3oncoprotein31.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
12 LATS2suppressor40.33338.762Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
13 LGALS3oncoprotein200Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
14 MDKoncoprotein100PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
15 MRPL58interactor21.0000RF-1 (PF00472, IPR000352): RF-1 domain
16 NDUFA4interactor200B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
17 NTRK1oncoprotein90.179188.238I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
18 PSMA3interactor31.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
19 PTNoncoprotein31.0000PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
20 PTPMT1interactor31.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
21 SYNCRIPinteractor40.6679.619RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
22 TBK1interactor40.6671.667DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
23 TNRoncoprotein100CBM_4_9 (PF02018, IPR003305): Carbohydrate binding domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Uroplakin_II (PF07353, IPR009952): Uroplakin II
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain

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