Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPRG, PRPF4B (from a repository: Sun Dec 11 13:23:45 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins15 (25.86 %)
The number (and %) of the tumor suppressors6 (10.34 %)
Total number of binary PPIs (saturation %)367 (22.20 %)
The number (and %) of affected PPIs57 (15.53 %)
The number of possible different fusions15
PPI diameter5
PPI radius3
The average degree of PPI11.724
Assortativity coefficient-0.1075
The network average Clustering coefficient0.481
The number (and %) of a zero Clustering coefficients11 (18.97 %)
The number (and %) of a zero Betweenness Centrality14 (24.14 %)


List of the fusions

PPI for parental proteins: PTPRG,PRPF4B All fusions
Proteins found in more fusions FAN1 (see 1 fusions); SNRNP200 (see 3 fusions); DLG4 (see 1 fusions); PRPF8 (see 3 fusions); PTPRG (see 1 fusions); YWHAG (see 1 fusions); LUC7L2 (see 2 fusions); HSP90AA1 (see 2 fusions); SRSF1 (see 1 fusions); PRPF6 (see 1 fusions); PRKCD (see 2 fusions); NUDT21 (see 2 fusions); SRPK2 (see 1 fusions); LUC7L (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PTPRGparental protein70540.000Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
TMEM119 (PF15724, IPR031453): TMEM119 family
2 PRPF4Bparental protein500.2291266.984Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
Ureide_permease (PF07168, IPR009834): Ureide permease
Pkinase (PF00069, IPR000719): Protein kinase domain
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
3 AKAP5interactor21.0000WSK (PF03832, IPR001573): WSK motif
4 ARRB2interactor110.41818.086Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 CCNL2interactor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
6 CDC5Linteractor220.49547.101OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
7 CLK1interactor80.4767.027PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
8 DDX23interactor150.8104.133DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3698 (PF12479, IPR022167): Protein of unknown function (DUF3698)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
9 DEUP1suppressor200APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
10 DLG4protein found in more fusions200L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 EFTUD2interactor230.60230.244EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
12 EPB41L3suppressor120.45525.2094_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
13 ESR1suppressor150.44023.905Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
14 FAN1protein found in more fusions200VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TPR_12 (PF13424): Tetratricopeptide repeat
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
15 FCN1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
16 FYTTD1interactor50613.467FYTT (PF07078, IPR009782): Forty-two-three protein
17 HSP90AA1oncoprotein120.49113.909HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
18 HSPB3interactor100HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19 KIF1Cinteractor31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
20 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
21 LUC7Lprotein found in more fusions130.56110.194LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
22 LUC7L2protein found in more fusions150.53813.871LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
23 MAGOHinteractor160.525316.296Mago_nashi (PF02792, IPR004023): Mago nashi protein
24 MAPK12oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Peripla_BP_5 (PF13433): Periplasmic binding protein domain
25 NCBP2interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 NIFKinteractor50.9000.154RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
27 NTRK1oncoprotein260.41784.516I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
28 NUDT21protein found in more fusions90.4647.509NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
29 OBSL1interactor260.43784.766BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
30 PNNsuppressor120.6068.397Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
31 POLR3Finteractor100RNA_pol_Rpc34 (PF05158, IPR007832): RNA polymerase Rpc34 subunit
32 PRKCDsuppressor40.6670.333Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
33 PRPF31interactor160.8193.761Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
34 PRPF4interactor160.7527.124PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
35 PRPF6protein found in more fusions200.69016.961PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
36 PRPF8oncoprotein250.56244.557PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
37 RNPS1interactor190.49733.863RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
38 RPL14interactor110.400203.666KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
39 RPL5suppressor130.48520.565Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
40 RPS11interactor60.5335.086Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
41 RRP1Binteractor110.52711.953Nop52 (PF05997, IPR010301): Nucleolar protein,Nop52
42 SART1interactor190.7398.711SART-1 (PF03343, IPR005011): SART-1 family
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
43 SHFM1interactor21.0000CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
44 SIRT7interactor140.39626.450DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
45 SNRNP200protein found in more fusions240.58536.019DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
46 SNRNP40interactor150.7909.152WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
47 SNRPBinteractor100.6226.687LSM (PF01423, IPR001163): LSM domain
48 SNRPD1interactor210.51946.554API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
LSM (PF01423, IPR001163): LSM domain
49 SRPK2oncoprotein220.41066.093DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
50 SRPK3interactor90.38911.844Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pkinase (PF00069, IPR000719): Protein kinase domain
51 SRRM2interactor230.49452.307cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
52 SRSF1protein found in more fusions190.50332.304Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
53 SUPT16Hinteractor110.600180.163Nop14 (PF04147, IPR007276): Nop14-like family
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
FACT-Spt16_Nlob (PF14826, IPR029148): FACT complex subunit SPT16 N-terminal lobe domain
54 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
55 USP39oncoprotein160.70819.416UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
56 XPO1interactor170.33145.337CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
57 YWHAGprotein found in more fusions140.42325.85814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
58 ZRANB2interactor70.5713.469RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

B a c k    t o    T o p ⇑