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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTPRA, LAMA5 (from a repository: Mon Dec 9 11:37:06 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins8 (27.59 %)
The number (and %) of the tumor suppressors3 (10.34 %)
Total number of binary PPIs (saturation %)52 (12.81 %)
The number (and %) of affected PPIs27 (51.92 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI2.828
Assortativity coefficient-0.5533
The network average Clustering coefficient0.221
The number (and %) of a zero Clustering coefficients17 (58.62 %)
The number (and %) of a zero Betweenness Centrality18 (62.07 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LAMA5,PTPRA All fusions
Proteins found in more fusions HSPB1 (see 4 fusions); FYN (see 1 fusions); GRB2 (see 1 fusions); YWHAZ (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LAMA5parental protein150.010482.167DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
2 PTPRAparental protein120.091261.033DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
3 BCAMinteractor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
4 CALM1interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5 COL7A1oncoprotein100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
DUF4249 (PF14054, IPR025345): Domain of unknown function (DUF4249)
DUF4992 (PF16383, IPR032155): Domain of unknown function
6 CRKLoncoprotein2027.881SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 DAG1interactor50.200169.190DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
8 FBLN2interactor200ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Metallothio_6 (PF05522, IPR017980): Metallothionein
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
9 FBXO6interactor30.333100.381FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
10 FCN1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
11 FYNoncoprotein50.50045.014Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 GABARAPL2interactor21.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
13 GRB2oncoprotein60.30062.695SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
14 HSPB1oncoprotein31.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
15 KCNA2interactor31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
16 LAMC1interactor21.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_I (PF06008, IPR009254): Laminin Domain I
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
17 LGALS8interactor3056.395Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 MEP1Ainteractor200Astacin (PF01400, IPR001506): Astacin (Peptidase family M12A)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pex24p (PF06398, IPR010482): Integral peroxisomal membrane peroxin
19 MYOCinteractor200IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
20 PPP4R3Ainteractor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
21 PTPRKsuppressor2028.881fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
22 RNASEH2Ainteractor100RNase_HII (PF01351, IPR024567): Ribonuclease HII
23 SMAD2suppressor200MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
24 SRConcoprotein50.66720.181Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
25 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
26 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
27 USP4oncoprotein200UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
28 UVRAGsuppressor100C2 (PF00168, IPR000008, SM00239): C2 domain
HTH_1 (PF00126, IPR000847): Bacterial regulatory helix-turn-helix protein, lysR family
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
29 YWHAZprotein found in more fusions60.300102.18114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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