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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KIAA1549, ATP6V0A4 (from a repository: Sat Aug 24 03:56:42 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins4 (25.00 %)
The number (and %) of the tumor suppressors2 (12.50 %)
Total number of binary PPIs (saturation %)22 (18.33 %)
The number (and %) of affected PPIs14 (63.64 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.250
Assortativity coefficient-0.1190
The network average Clustering coefficient0.420
The number (and %) of a zero Clustering coefficients8 (50.00 %)
The number (and %) of a zero Betweenness Centrality14 (87.50 %)


List of the fusions

PPI for parental proteins: ATP6V0A4,KIAA1549 All fusions
Proteins found in more fusions ITSN2 (see 5 fusions); PFKM (see 1 fusions); LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ATP6V0A4parental protein100V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
2 KIAA1549parental protein130.051147.000DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
3 CADPSinteractor100DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
PH (PF00169, IPR001849, SM00233): PH domain
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
4 DSToncoprotein30.6671.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Phasin (PF05597, IPR008769): Poly(hydroxyalcanoate) granule associated protein (phasin)
Spectrin (PF00435, IPR002017): Spectrin repeat
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
XhlA (PF10779, IPR019715): Haemolysin XhlA
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
NYD-SP28 (PF14772): Sperm tail
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
5 FCN1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
6 HLA-Finteractor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
7 ITSN2protein found in more fusions31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
8 LATS1suppressor21.0000Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
9 LATS2suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
10 LGALS3oncoprotein31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
11 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
12 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
13 MBD5interactor100MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pap_E4 (PF02711, IPR003861): E4 protein
PWWP (PF00855, IPR000313, SM00293): PWWP domain
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
14 MYO5Binteractor1005_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DIL (PF01843, IPR018444, SM01132): DIL domain
Fez1 (PF06818): Fez1
HalX (PF08663, IPR013971): HalX domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF3251 (PF11622, IPR021658): Protein of unknown function (DUF3251)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
15 PFKMprotein found in more fusions200PFK (PF00365, IPR000023): Phosphofructokinase
16 TMEM17interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)

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