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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PHF12 (from a repository: Wed May 31 10:58:38 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins2 (12.50 %)
The number (and %) of the tumor suppressors5 (31.25 %)
Total number of binary PPIs (saturation %)77 (64.17 %)
The number (and %) of affected PPIs15 (19.48 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI9.125
Assortativity coefficient-0.3817
The network average Clustering coefficient0.748
The number (and %) of a zero Clustering coefficients2 (12.50 %)
The number (and %) of a zero Betweenness Centrality5 (31.25 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: PHF12 All fusions
: BF823276;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PHF12parental protein150.55260.994FHA (PF00498, IPR000253, SM00240): FHA domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PHF12_MRG_bd (PF16737, IPR031966): PHD finger protein 12 MRG binding domain
2 BRCA1suppressor71.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
3 EMSYoncoprotein71.0000ENT (PF03735, IPR005491): ENT domain
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
GTA_TIM (PF13547, IPR025195): GTA TIM-barrel-like domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
4 GATAD1interactor100.9111.127GATA (PF00320, IPR000679, SM00401): GATA zinc finger
5 HDAC1suppressor140.7446.994FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
6 HDAC2suppressor140.7446.994Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
7 HIST3H3interactor100.8891.405Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
8 KDM5Asuppressor90.9720.222ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
FRG1 (PF06229, IPR010414): FRG1-like domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
9 MORF4L1interactor130.8034.194MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
10 MORF4L2interactor100.8671.833MRG (PF05712, IPR026541): MRG
11 RBBP7suppressor120.7884.756WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
12 S100A4interactor100S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
13 SAP30interactor61.0000Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
14 SIN3Aoncoprotein90.8891.222Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
15 SIN3Binteractor120.8034.260Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
16 SPICE1interactor100SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression
ANXA2R (PF15721, IPR031449): Annexin-2 receptor
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 PHF12parental proteinFHA (PF00498, IPR000253, SM00240): FHA domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PHF12_MRG_bd (PF16737, IPR031966): PHD finger protein 12 MRG binding domain
BF823276

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