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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)80
The number (and %) of the onco-proteins24 (30.00 %)
The number (and %) of the tumor suppressors12 (15.00 %)
Total number of binary PPIs (saturation %)374 (11.84 %)
The number (and %) of affected PPIs79 (21.12 %)
The number of possible different fusions15
PPI diameter5
PPI radius3
The average degree of PPI8.500
Assortativity coefficient-0.1647
The network average Clustering coefficient0.478
The number (and %) of a zero Clustering coefficients7 (8.75 %)
The number (and %) of a zero Betweenness Centrality13 (16.25 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PPP6R3,SH3RF1 All fusions
Proteins found in more fusions TERF2IP (see 1 fusions); GRK5 (see 4 fusions); TPM1 (see 2 fusions); PRKDC (see 3 fusions); SH3RF1 (see 1 fusions); HSP90AA1 (see 2 fusions); USP10 (see 1 fusions); SIAH2 (see 1 fusions); HSP90AB1 (see 1 fusions); SIAH1 (see 4 fusions); RAC1 (see 1 fusions); CDC37 (see 2 fusions); CSNK1E (see 1 fusions); UBE2N (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PPP6R3parental protein610.1132807.294SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
2 SH3RF1parental protein180.081515.923zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
3 ACAD11interactor21.0000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
APH (PF01636, IPR002575): Phosphotransferase enzyme family
4 AKT1oncoprotein100.33384.276PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 AKT2oncoprotein40.50023.021PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6 ANKRD28interactor150.40054.589Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
7 ANKRD44oncoprotein90.7505.551Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
8 ANKRD52interactor110.50918.746Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
9 AP1B1interactor70.6673.733Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
10 AP2A1interactor70.5718.508Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
11 AP2A2interactor50.8001.015Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
12 AURKAoncoprotein130.39449.549Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
13 BRCA1suppressor210.200337.857BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
14 CDC37protein found in more fusions120.43662.324CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
15 CEP19interactor31.0000CEP19 (PF14933, IPR029412): CEP19-like protein
16 CEP44interactor50.9000.222DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
17 CSNK1Eprotein found in more fusions51.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
18 DIEXFinteractor30.6670.348UTP25 (PF06862, IPR010678): Utp25, U3 small nucleolar RNA-associated SSU processome protein 25
eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
SDA1 (PF05285, IPR007949): SDA1
19 DNAJC11suppressor40.6672.834DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
20 ECH1interactor21.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
21 ECT2suppressor204.514BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
22 EIF4A3interactor60.5006.090DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 ELAVL1oncoprotein190.242192.961RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 ENAHoncoprotein50.8002.575MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
25 ERLIN2interactor40.6672.802Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
26 ETFAinteractor30.6671.000ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
27 GPHA2interactor100DAN (PF03045, IPR004133): DAN domain
28 GPSM1interactor41.0000GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
TPR_12 (PF13424): Tetratricopeptide repeat
29 GRK5protein found in more fusions110.35653.113Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
30 HDAC1suppressor90.57111.493FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
31 HDAC11interactor40.6671.606Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
32 HDAC2suppressor130.39436.730Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
33 HERPUD1oncoprotein30.3338.414Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
34 HSP90AA1oncoprotein180.316254.263HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
35 HSP90AB1oncoprotein160.362111.575HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
36 KCNJ1interactor100IRK (PF01007, IPR016449): Inward rectifier potassium channel
37 KDM6Asuppressor21.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
38 LATS1suppressor70.238153.304Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
39 MAP3K11interactor70.53327.239APG6 (PF04111, IPR007243): Autophagy protein Apg6
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
40 MAP4K3interactor2030.070CNH (PF00780, IPR001180, SM00036): CNH domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
41 MOB1Asuppressor100.66714.557Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
42 MOB1Bsuppressor80.7867.404Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
43 NINLinteractor3024.135PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
44 NOTCH1suppressor110.33342.601Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
45 NSUN5interactor100Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
BrnA_antitoxin (PF14384, IPR025528): BrnA antitoxin of type II toxin-antitoxin system
46 NTRK1oncoprotein350.153682.103I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
47 PDCD6IPinteractor60.40066.610BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
48 PFASinteractor30.6670.348AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
49 PPP6Cinteractor200.368117.547Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
50 PPP6R1interactor190.36897.638CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
51 PPP6R2interactor140.53826.177SAMP (PF05924, IPR009224): SAMP Motif
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
52 PRKDCprotein found in more fusions180.309157.907FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
53 RAC1oncoprotein50.33320.885Ras (PF00071, IPR001806, SM00173): Ras family
54 RNF2interactor150.286191.894zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
55 RPS6KB2interactor70.5247.215Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
56 RUVBL2oncoprotein110.51116.650TIP49 (PF06068, IPR010339): TIP49 C-terminus
57 SEMA6Ainteractor100PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
58 SH3RF2interactor40.5008.813SH3_2 (PF07653, IPR011511): Variant SH3 domain
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SH3_9 (PF14604, IPR001452): Variant SH3 domain
59 SIAH1suppressor80.42927.154Sina (PF03145, IPR018121): Seven in absentia protein family
60 SIAH2oncoprotein60.50020.412Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
61 SIRT7interactor130.26966.940DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
62 SNAI2oncoprotein31.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
KCNQ2_u3 (PF16642): Unstructured region on Potassium channel subunit alpha KvLQT2
63 SRRTinteractor60.5335.308ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
64 TERF2IPprotein found in more fusions70.33317.851BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
65 TFAP4oncoprotein60.6005.933DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
66 TINF2interactor70.33384.643TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
67 TIPRLinteractor40.8330.500TIP41 (PF04176, IPR007303): TIP41-like family
68 TNFAIP3suppressor70.33331.447OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
69 TPM1protein found in more fusions60.4006.828Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
70 UBE2D1interactor80.19053.264UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
71 UBE2D3interactor80.33362.999UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
72 UBE2Nprotein found in more fusions90.28669.914UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
73 UNKinteractor70.38132.659MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
74 USP10protein found in more fusions51.0000PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
YukD (PF08817, IPR024962): WXG100 protein secretion system (Wss), protein YukD
75 USP21interactor60.5002.405UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
76 USP36interactor21.0000TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
77 USP49interactor50.9000.222UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
78 USP7oncoprotein150.264193.552MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
79 XPO1interactor230.253170.430CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
80 YWHABinteractor80.17993.51214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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