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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RANBP10, BPIFA1 (from a repository: Fri Feb 9 09:23:33 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins6 (17.65 %)
The number (and %) of the tumor suppressors5 (14.71 %)
Total number of binary PPIs (saturation %)80 (14.26 %)
The number (and %) of affected PPIs32 (40.00 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI4.000
Assortativity coefficient-0.3046
The network average Clustering coefficient0.450
The number (and %) of a zero Clustering coefficients13 (38.24 %)
The number (and %) of a zero Betweenness Centrality22 (64.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BPIFA1,RANBP10 All fusions
Proteins found in more fusions UBQLN1 (see 2 fusions); NEDD4L (see 3 fusions); PRKCD (see 2 fusions); NEDD4 (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BPIFA1parental protein70.143191.067LBP_BPI_CETP (PF01273, IPR017942, SM00328): LBP / BPI / CETP family, N-terminal domain
2 RANBP10parental protein250.093709.105LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
3 CNTNAP4interactor100COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
4 DRD1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 GDNFinteractor21.0000TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
6 GID8interactor110.48921.529LisH (PF08513, IPR013720, SM00667): LisH
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
7 GLIPR1L2interactor21.0000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family
8 GPS2oncoprotein31.0000G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
9 HLA-DPB1interactor31.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
10 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
11 IGSF1interactor200UEV (PF05743, IPR008883): UEV domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
12 LNX1interactor200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
13 MEGF10interactor100DSL (PF01414, IPR001774, SM00051): Delta serrate ligand
EGF_2 (PF07974, IPR013111): EGF-like domain
Syndecan (PF01034, IPR027789): Syndecan domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
14 METoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
15 MMP7interactor31.0000Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
16 MRPL39interactor31.0000TGS (PF02824, IPR004095): TGS domain
DUF2469 (PF10611, IPR019592): Protein of unknown function (DUF2469)
17 MRPL4interactor60.8004.343Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
18 NEDD4suppressor4095.995Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
19 NEDD4Lsuppressor50.167116.448WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
20 NOTCH1suppressor40.6675.452Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
21 PRG2interactor41.0000Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
22 PRKCDsuppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
23 PRKCGinteractor200C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
24 RANoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
25 RMND5Ainteractor120.36446.195CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SnoaL_4 (PF13577, IPR009959): SnoaL-like domain
26 SMAD6interactor3059.371MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
27 SOX2oncoprotein70.8004.343HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
28 TDGF1suppressor41.0000CFC (PF09443, IPR019011): Cripto_Frl-1_Cryptic (CFC)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
29 THSD7Binteractor100TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
DUF3709 (PF12493, IPR022178): Protein of unknown function (DUF3709)
DUF3961 (PF13106, IPR025081): Domain of unknown function (DUF3961)
30 TMEM237interactor100TMEM237 (PF15383, IPR029409): Transmembrane protein 237
31 UBCprotein found in more fusions70.200257.162ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
32 UBQLN1protein found in more fusions41.0000Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
33 UBQLN4interactor41.0000CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
34 WDR26interactor80.571160.990eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1

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