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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DIP2B, CD63 (from a repository: Wed Jan 20 17:15:28 2021)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins8 (28.57 %)
The number (and %) of the tumor suppressors2 (7.14 %)
Total number of binary PPIs (saturation %)73 (19.31 %)
The number (and %) of affected PPIs26 (35.62 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI4.714
Assortativity coefficient-0.1340
The network average Clustering coefficient0.553
The number (and %) of a zero Clustering coefficients3 (10.71 %)
The number (and %) of a zero Betweenness Centrality11 (39.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DIP2B,CD63 All fusions
Proteins found in more fusions LGALS3 (see 2 fusions); SQSTM1 (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DIP2Bparental protein60.26773.200AMP-binding (PF00501, IPR000873): AMP-binding enzyme
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
2 CD63parental protein200.158344.649Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
3 ATP6V1B1interactor21.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
4 AUP1interactor21.0000CUE (PF02845, IPR003892, SM00546): CUE domain
5 CD81interactor80.57110.217Tetraspannin (PF00335, IPR018499): Tetraspanin family
6 CD82suppressor70.47613.914Tetraspannin (PF00335, IPR018499): Tetraspanin family
7 CD9oncoprotein90.38966.953Tetraspannin (PF00335, IPR018499): Tetraspanin family
8 EFNB2interactor100Ephrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
9 ELAVL1oncoprotein70.200104.050RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 FAM134Cinteractor205.805Reticulon (PF02453, IPR003388): Reticulon
11 HLA-DMBinteractor31.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
12 HLA-DOBinteractor21.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
13 HLA-DRAinteractor31.0000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
14 ITGB1suppressor80.321114.991EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
15 KIToncoprotein31.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
16 LGALS3oncoprotein60.50043.363Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
17 LGALS8interactor50.4008.073Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 LGALS9interactor50.6007.490Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
19 NTRK1oncoprotein70.33390.437I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 PTGFRNinteractor70.47610.500V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
21 RAD21oncoprotein21.0000Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
22 RNF13interactor40.5002.167DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
23 SDC1oncoprotein21.0000Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
24 SDCBPinteractor50.30031.254PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
25 SQSTM1oncoprotein40.33315.713PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
26 SRFinteractor200SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
27 TSPAN3interactor30.6671.224Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
28 VKORC1interactor41.0000VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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