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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MKL1, XPNPEP3 (from a repository: Fri Aug 23 08:51:28 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins9 (21.95 %)
The number (and %) of the tumor suppressors6 (14.63 %)
Total number of binary PPIs (saturation %)127 (15.49 %)
The number (and %) of affected PPIs40 (31.50 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI5.220
Assortativity coefficient-0.2749
The network average Clustering coefficient0.442
The number (and %) of a zero Clustering coefficients7 (17.07 %)
The number (and %) of a zero Betweenness Centrality12 (29.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MKL1,XPNPEP3 All fusions
Proteins found in more fusions MVP (see 2 fusions); MKL2 (see 1 fusions); UBR5 (see 4 fusions); CUL3 (see 1 fusions); VIM (see 1 fusions); ACTB (see 7 fusions); XPNPEP3/IDE (see 1 fusions); SMAD3 (see 3 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MKL1parental protein210.124554.056RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SAP (PF02037, IPR003034, SM00513): SAP domain
Troponin-I_N (PF11636, IPR021666): Troponin I residues 1-32
2 XPNPEP3parental protein190.144459.312AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
3 ACTBoncoprotein50.66711.447Actin (PF00022, IPR004000, SM00268): Actin
4 BAG3oncoprotein60.10066.999BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 C1QBPinteractor80.39352.399MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
6 C2orf47interactor41.0000Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
7 CEP19interactor100CEP19 (PF14933, IPR029412): CEP19-like protein
8 CEP63interactor21.0000DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
9 CFTRsuppressor308.712ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
10 CHCHD2interactor90.46425.044CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
11 CUL3protein found in more fusions120.164189.766Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
12 DNMT1suppressor31.0000BAH (PF01426, IPR001025, SM00439): BAH domain
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DNMT1-RFD (PF12047, IPR022702): Cytosine specific DNA methyltransferase replication foci domain
13 DYRK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
14 ECH1interactor40.50080.308ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15 GSK3Bsuppressor80.38166.960Pkinase (PF00069, IPR000719): Protein kinase domain
16 IDEprotein found in more fusions31.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
17 KDM3Asuppressor30.6670.500C1_2 (PF03107, IPR004146): C1 domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
18 KIAA0753interactor40.33384.208MNR (PF15718, IPR031447): Protein moonraker
19 LACE1interactor50.8331.600AFG1_ATPase (PF03969, IPR005654): AFG1-like ATPase
20 LCA5interactor21.0000IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
21 MKL2protein found in more fusions60.50011.176RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SAP (PF02037, IPR003034, SM00513): SAP domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
22 MRPL53interactor100MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
23 MRPL57interactor100MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
24 MVPoncoprotein308.477Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
25 MYOCDinteractor60.5339.049BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
IncA (PF04156, IPR007285): IncA protein
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SAP (PF02037, IPR003034, SM00513): SAP domain
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
26 NCOA3oncoprotein70.42941.065DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
27 NT5DC2interactor21.00005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
28 NXF1interactor80.28685.196NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
29 OBSL1interactor80.23896.653BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
30 PAK5interactor60.7002.577PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
31 POLDIP2interactor50.50038.906DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
32 RPGRIP1interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
RNA_binding (PF01877, IPR002739): RNA binding
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
COX16 (PF14138, IPR020164): Cytochrome c oxidase assembly protein COX16
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
33 SMAD3oncoprotein80.42928.387MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
34 SMARCA4suppressor70.38161.863DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
35 SRFinteractor60.5003.833SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
36 SSRP1interactor50.50018.035Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like
SSrecog (PF03531, IPR024954): Structure-specific recognition protein (SSRP1)
YABBY (PF04690, IPR006780): YABBY protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
CAML (PF14963, IPR016719): Calcium signal-modulating cyclophilin ligand
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
Coilin_N (PF15862, IPR031722): Coilin N-terminus
37 SUPT16Hinteractor60.50021.483Nop14 (PF04147, IPR007276): Nop14-like family
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
FACT-Spt16_Nlob (PF14826, IPR029148): FACT complex subunit SPT16 N-terminal lobe domain
38 TCTN1interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
39 UBR5protein found in more fusions70.33374.918CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
40 VIMsuppressor60.30031.544Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
41 XPO1interactor100.244129.526CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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