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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EFNA5, LRRC7 (from a repository: Mon Feb 20 16:43:09 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins7 (41.18 %)
The number (and %) of the tumor suppressors1 (5.88 %)
Total number of binary PPIs (saturation %)27 (19.85 %)
The number (and %) of affected PPIs15 (55.56 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI2.235
Assortativity coefficient-0.4668
The network average Clustering coefficient0.282
The number (and %) of a zero Clustering coefficients10 (58.82 %)
The number (and %) of a zero Betweenness Centrality12 (70.59 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EFNA5,LRRC7 All fusions
Proteins found in more fusions CUL3 (see 1 fusions); DLG4 (see 1 fusions); GRIP1 (see 2 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EFNA5parental protein60.067128.000Ephrin (PF00812, IPR001799): Ephrin
2 LRRC7parental protein90.056179.000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
3 ADGRB1interactor31.00007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
GAIN (PF16489, IPR032471): GPCR-Autoproteolysis INducing (GAIN) domain
4 CDH2interactor100Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
5 CNKSR2interactor100DUF1170 (PF06663, IPR010599): Protein of unknown function (DUF1170)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
CRIC_ras_sig (PF10534, IPR019555): Connector enhancer of kinase suppressor of ras
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
6 CTNND2oncoprotein100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
7 CUL3protein found in more fusions31.0000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
8 DLG4protein found in more fusions40.6671.000L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 EPHA3suppressor21.0000EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
10 EPHA7oncoprotein100EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
11 EPHB1interactor100EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
12 GRIP1protein found in more fusions200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
13 HOMEZinteractor100Homeobox_KN (PF05920, IPR008422): Homeobox KN domain
Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 MYConcoprotein30120.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
15 NQO2interactor30126.000Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
16 SRConcoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17 SSSCA1interactor200Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)

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