Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HSH2D, TAOK1 (from a repository: Sat Aug 31 12:28:05 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins8 (30.77 %)
The number (and %) of the tumor suppressors2 (7.69 %)
Total number of binary PPIs (saturation %)43 (13.23 %)
The number (and %) of affected PPIs24 (55.81 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI2.538
Assortativity coefficient-0.3587
The network average Clustering coefficient0.343
The number (and %) of a zero Clustering coefficients14 (53.85 %)
The number (and %) of a zero Betweenness Centrality19 (73.08 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions PINK1 (see 3 fusions); TNK2 (see 1 fusions); SNW1 (see 1 fusions); MAP3K7 (see 7 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TAOK1parental protein120.061311.000Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Pkinase (PF00069, IPR000719): Protein kinase domain
PKK (PF12474, IPR022165): Polo kinase kinase
TcdB_N (PF12918, IPR024772): TcdB toxin N-terminal helical domain
2 HSH2Dparental protein120.045385.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
3 C8orf33interactor100DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
4 CNMDinteractor100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
5 CRKoncoprotein21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
6 CSNK1Einteractor31.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
7 DYNC1I1interactor100CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
8 FESoncoprotein200FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
9 GEMIN7interactor100Gemin7 (PF11095, IPR020338): Gem-associated protein 7 (Gemin7)
SUZ-C (PF12901, IPR024642): SUZ-C motif
10 LDHAL6Binteractor100Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
11 MAP3K7oncoprotein30111.000Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
12 MPP3interactor100L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
13 NTRK1oncoprotein60.300180.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
14 OLIG1interactor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
15 PIK3R3interactor40.5003.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
16 PINK1protein found in more fusions30111.000Pkinase (PF00069, IPR000719): Protein kinase domain
17 PLPP6interactor100PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
PAP2_C (PF14360, IPR025749): PAP2 superfamily C-terminal
18 RBP7interactor21.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
19 SNW1protein found in more fusions31.0000SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
20 SRBD1interactor21.0000S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain
HHH_3 (PF12836): Helix-hairpin-helix motif
DLD (PF14878, IPR027999): Death-like domain of SPT6
Tex_YqgF (PF16921, IPR032639): Tex protein YqgF-like domain
21 STK25interactor21.0000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
22 STK26interactor31.0000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
23 STK4oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
24 TNK2protein found in more fusions30177.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
25 TSC1suppressor200Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Hamartin (PF04388, IPR007483): Hamartin protein
26 WT1suppressor100WT1 (PF02165, IPR000976): Wilm's tumour protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
CCAP (PF11105, IPR024276): Arthropod cardioacceleratory peptide 2a
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

B a c k    t o    T o p ⇑