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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TXNDC16, ADGRE5 (from a repository: Mon Jul 29 08:19:22 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins7 (29.17 %)
The number (and %) of the tumor suppressors2 (8.33 %)
Total number of binary PPIs (saturation %)48 (17.39 %)
The number (and %) of affected PPIs22 (45.83 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI3.667
Assortativity coefficient-0.3675
The network average Clustering coefficient0.478
The number (and %) of a zero Clustering coefficients8 (33.33 %)
The number (and %) of a zero Betweenness Centrality14 (58.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ADGRE5,TXNDC16 All fusions
Proteins found in more fusions MCM2 (see 1 fusions); HNRNPD (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ADGRE5parental protein70234.0007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_MSP1_1 (PF12946, IPR024730): MSP1 EGF domain 1
2 TXNDC16parental protein150.152164.333Thioredoxin (PF00085, IPR013766): Thioredoxin
DUF4147 (PF13660, IPR025286): Domain of unknown function (DUF4147)
Thioredoxin_6 (PF13848): Thioredoxin-like domain
3 ATP5F1interactor21.0000Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
4 ENO1oncoprotein50.60026.000Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
5 EXOSC4interactor40.6677.333RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
6 FLNAsuppressor40.50024.333CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
7 FOXRED2interactor21.0000Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
8 GGHoncoprotein31.0000Peptidase_C26 (PF07722, IPR011697): Peptidase C26
9 GOLT1Binteractor100Got1 (PF04178, IPR007305): Got1/Sft2-like family
10 HNRNPA2B1oncoprotein40.8337.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 HNRNPDoncoprotein80.286230.667CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
12 HNRNPUinteractor70.42947.667CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
13 KNL1oncoprotein100DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
14 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
15 MARCKSsuppressor21.0000MARCKS (PF02063, IPR002101): MARCKS family
16 MCM2oncoprotein110.33380.333AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
17 PPIBinteractor40.6676.000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
18 RPL35interactor21.0000Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
19 TAGLN2interactor31.0000Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
20 TAZinteractor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
21 TCTN1interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
22 TMEM171interactor100TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
23 TMEM63Binteractor100RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
24 XRN1interactor100XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus

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