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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)70
The number (and %) of the onco-proteins22 (31.43 %)
The number (and %) of the tumor suppressors5 (7.14 %)
Total number of binary PPIs (saturation %)288 (11.93 %)
The number (and %) of affected PPIs70 (24.31 %)
The number of possible different fusions12
PPI diameter3
PPI radius2
The average degree of PPI7.457
Assortativity coefficient-0.1550
The network average Clustering coefficient0.464
The number (and %) of a zero Clustering coefficients13 (18.57 %)
The number (and %) of a zero Betweenness Centrality16 (22.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SDK1,XPO5 All fusions
Proteins found in more fusions NUP153 (see 2 fusions); ARIH1 (see 4 fusions); LGALS3 (see 2 fusions); SMAD4 (see 3 fusions); LNX1 (see 1 fusions); EEF1A1 (see 6 fusions); EGFR (see 2 fusions); NUP214 (see 2 fusions); UBC (see 7 fusions); PRPF40A (see 2 fusions); MYC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SDK1parental protein6029.556fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
2 XPO5parental protein640.0893212.488IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
3 AARSD1interactor70.6195.500tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ARIH1protein found in more fusions60.6003.400CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
5 BAG1oncoprotein21.0000BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
6 CA9interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
Octapeptide (PF03373, IPR005038): Octapeptide repeat
DUF4730 (PF15873, IPR031742): Domain of unknown function (DUF4730)
7 CDC5Linteractor80.52434.187OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
8 CHORDC1interactor200CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
9 CLEC12Ainteractor100Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
10 CLN3interactor100CLN3 (PF02487, IPR003492): CLN3 protein
11 DUS3Linteractor40.6672.000Dus (PF01207, IPR001269): Dihydrouridine synthase (Dus)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
12 EEF1A1suppressor130.47019.787GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
13 EFTUD2interactor180.30190.728EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
14 EGFRoncoprotein140.295101.961Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
15 ELAC2oncoprotein80.46412.967Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease
16 FN1oncoprotein180.268153.709fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
17 GSTK1interactor60.8000.619DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
18 GTF2E1interactor70.7622.300DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
19 HARSinteractor120.42426.806HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
20 HSPA5oncoprotein130.50019.179HSP70 (PF00012, IPR013126): Hsp70 protein
21 ILF3oncoprotein130.372107.189dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
22 ITGA4interactor130.40953.242FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
23 ITGB1BP2interactor100CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
24 KRBOX4interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
25 LCA5interactor21.0000IncA (PF04156, IPR007285): IncA protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
26 LGALS3oncoprotein50.1676.293Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
27 LGALS8interactor40.3335.073Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
28 LNX1protein found in more fusions407.448PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
29 MAGEA6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
30 MAT2Binteractor50.8001.167RmlD_sub_bind (PF04321, IPR005913): RmlD substrate binding domain
31 MMS19interactor80.32125.152DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
32 MOV10interactor90.4729.897AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
33 MRTO4interactor50.7001.400Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
34 MYConcoprotein110.31177.615HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
35 NEK6interactor3037.563Pkinase (PF00069, IPR000719): Protein kinase domain
36 NOTCH1suppressor40.6671.000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
37 NRDCinteractor120.45519.539Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
38 NSUN2interactor120.30342.841Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
39 NTRK1oncoprotein270.215266.356I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
40 NUP153protein found in more fusions90.46411.037Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
41 NUP214oncoprotein100.41715.201dCache_2 (PF08269, IPR004010, SM01049): Cache domain
HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1
NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
42 NUP98suppressor41.0000Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
Nup96 (PF12110, IPR021967): Nuclear protein 96
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
43 NXF1interactor140.28243.474NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
44 P3H1interactor110.41829.208TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
YfiO (PF13525): Outer membrane lipoprotein
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
MCM_N (PF14551, IPR027925): MCM N-terminal domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
45 PDIA6interactor110.41829.808FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
46 PFDN5interactor80.50010.028Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
47 PHLDA3suppressor30.6670.500PH (PF00169, IPR001849, SM00233): PH domain
48 PPME1interactor60.7002.500Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
49 PPP1R12Ainteractor70.6674.267DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
50 PPP3CAinteractor60.8001.500Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
51 PRPF40Aprotein found in more fusions5011.390FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
52 PTP4A3oncoprotein21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
53 RAB11Aoncoprotein50.9000.182Ras (PF00071, IPR001806, SM00173): Ras family
54 RANoncoprotein80.39311.458Ras (PF00071, IPR001806, SM00173): Ras family
55 SARSinteractor100.51119.822NOD (PF06816, IPR010660): NOTCH protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
56 SERINC3oncoprotein100Serinc (PF03348, IPR005016): Serine incorporator (Serinc)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
57 SERPINE2interactor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
58 SHMT1interactor50.6672.250SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
59 SIRT7interactor100.31145.753DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
60 SMAD4suppressor70.40026.234MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
61 SNX5oncoprotein31.0000PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
62 SOX2oncoprotein40.6670.667HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
63 TTC1interactor80.6077.567TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
64 UBCprotein found in more fusions120.38261.105ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
65 UCHL5oncoprotein60.9000.500Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
66 UGDHinteractor50.8330.8333HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
UDPG_MGDP_dh (PF00984, IPR014026): UDP-glucose/GDP-mannose dehydrogenase family, central domain
UDPG_MGDP_dh_C (PF03720, IPR014027, SM00984): UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
UDPG_MGDP_dh_N (PF03721, IPR001732): UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
67 VCAM1interactor80.5366.024C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
68 VSIG2interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
69 WDR4interactor50.7001.733WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
70 ZNF346interactor21.0000zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type

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