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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FHAD1, KIDINS220 (from a repository: Sun Oct 21 17:30:54 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins7 (25.00 %)
The number (and %) of the tumor suppressors2 (7.14 %)
Total number of binary PPIs (saturation %)66 (17.46 %)
The number (and %) of affected PPIs26 (39.39 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI4.357
Assortativity coefficient-0.3633
The network average Clustering coefficient0.463
The number (and %) of a zero Clustering coefficients9 (32.14 %)
The number (and %) of a zero Betweenness Centrality14 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FHAD1,KIDINS220 All fusions
Proteins found in more fusions MYC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FHAD1interactor000DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
FHA (PF00498, IPR000253, SM00240): FHA domain
IncA (PF04156, IPR007285): IncA protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
Phage_int_SAM_1 (PF02899, IPR004107): Phage integrase, N-terminal SAM-like domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
2 KIDINS220parental protein260.108500.167KAP_NTPase (PF07693, IPR011646): KAP family P-loop domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
3 ATP6AP2interactor50.8330.667Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
4 CEACAM21interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
5 CGRRF1interactor100zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 CLTConcoprotein70.5247.333Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
7 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
8 FAF2interactor41.0000DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
9 FN1oncoprotein70.5246.500fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
10 GAKoncoprotein50.7002.000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
11 GOLT1Binteractor31.0000Got1 (PF04178, IPR007305): Got1/Sft2-like family
12 GTSE1interactor40.6671.500GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
13 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
14 KIF5Binteractor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
15 LDLRAD4interactor100Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
16 LGR4interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
17 MOB4interactor100Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
18 MYConcoprotein40.6670.333HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
19 MYEF2interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20 NTRK1oncoprotein110.28929.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 PTPN1suppressor30.6671.000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
22 RAB11Aoncoprotein70.6195.333Ras (PF00071, IPR001806, SM00173): Ras family
23 RAB5Concoprotein80.5369.833Ras (PF00071, IPR001806, SM00173): Ras family
24 RAB7Asuppressor80.46412.667Ras (PF00071, IPR001806, SM00173): Ras family
25 TMEM17interactor40.6672.000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
26 TXNDC15interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
27 VAPAinteractor50.7001.667DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
28 VSIG4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain

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