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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BMS1, TENM2 (from a repository: Tue Aug 13 19:28:48 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins3 (17.65 %)
The number (and %) of the tumor suppressors1 (5.88 %)
Total number of binary PPIs (saturation %)36 (26.47 %)
The number (and %) of affected PPIs15 (41.67 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI3.765
Assortativity coefficient-0.2342
The network average Clustering coefficient0.504
The number (and %) of a zero Clustering coefficients4 (23.53 %)
The number (and %) of a zero Betweenness Centrality7 (41.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BMS1,TENM2 All fusions
Proteins found in more fusions GRK5 (see 2 fusions); CSNK2A1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BMS1parental protein150.162146.333AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
E7 (PF00527, IPR000148): E7 protein, Early protein
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
NOA36 (PF06524, IPR010531): NOA36 protein
2 TENM2interactor000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
NHL (PF01436, IPR001258): NHL repeat
RHS_repeat (PF05593, IPR006530): RHS Repeat
Ten_N (PF06484, IPR009471): Teneurin Intracellular Region
DUF2283 (PF10049, IPR019270): Protein of unknown function (DUF2283)
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
Tox-GHH (PF15636, IPR028916): GHH signature containing HNH/Endo VII superfamily nuclease toxin
3 CSNK2A1oncoprotein50.6671.500Pkinase (PF00069, IPR000719): Protein kinase domain
4 FOXM1oncoprotein100EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
5 GRK5protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
6 HDGFinteractor30.6671.000PWWP (PF00855, IPR000313, SM00293): PWWP domain
7 HIST1H3Einteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
8 IFI16suppressor40.6671.333HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
9 MEX3Cinteractor21.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 NIFKinteractor50.6003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
11 NXF1interactor80.33313.500NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 RNF2interactor50.5002.000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
13 RPSAinteractor30.6670.500Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
14 RRS1interactor40.8330.500GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
15 SHMT2interactor100SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
16 SIRT7interactor60.4676.333DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
17 USP42interactor100TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1

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