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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)59
The number (and %) of the onco-proteins11 (18.64 %)
The number (and %) of the tumor suppressors8 (13.56 %)
Total number of binary PPIs (saturation %)127 (7.42 %)
The number (and %) of affected PPIs58 (45.67 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.695
Assortativity coefficient-0.3975
The network average Clustering coefficient0.442
The number (and %) of a zero Clustering coefficients21 (35.59 %)
The number (and %) of a zero Betweenness Centrality35 (59.32 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC30A6,BIRC6 All fusions
Proteins found in more fusions CSNK2A1 (see 1 fusions); BIRC6 (see 1 fusions); ACTB (see 5 fusions); TP53 (see 3 fusions); UBC (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC30A6parental protein130.115819.447Cation_efflux (PF01545, IPR002524): Cation efflux family
2 BIRC6parental protein450.0402531.146BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
SlyX (PF04102, IPR007236): SlyX
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
3 ABRAXAS2interactor31.0000Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
4 ACTBoncoprotein50.167347.518Actin (PF00022, IPR004000, SM00268): Actin
5 ACTBL2interactor20167.751Actin (PF00022, IPR004000, SM00268): Actin
6 ANAPC11interactor60.6008.383zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
7 B3GNT3interactor21.0000Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
8 C12orf43interactor100RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
9 C3orf20interactor100FAM194 (PF14977, IPR029281): FAM194 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 CA11interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
11 CASP3interactor51.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CASP7interactor51.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
13 CASP8suppressor70.60037.182DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
14 CASP9oncoprotein41.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
15 CCNA2oncoprotein60.50019.180Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
16 CDC27oncoprotein50.6672.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
17 CHIAinteractor100Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
Serglycin (PF04360, IPR007455): Serglycin
CBM_14 (PF01607, IPR002557, SM00494): Chitin binding Peritrophin-A domain
18 CHRNA9interactor30.66725.858Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
19 CLEC11Ainteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
20 CSNK2A1oncoprotein50.8330.500Pkinase (PF00069, IPR000719): Protein kinase domain
21 DFNA5suppressor100Gasdermin (PF04598, IPR007677): Gasdermin family
22 DIABLOsuppressor31.0000Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
23 EPS15L1oncoprotein30.6671.000CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
24 FAM58Ainteractor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
25 GBF1interactor21.0000DUF1045 (PF06299, IPR009389): Protein of unknown function (DUF1045)
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
DUF758 (PF05527, IPR008477): Domain of unknown function (DUF758)
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
26 HDGFL3interactor100PPP4R2 (PF09184, IPR015267): PPP4R2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
27 HERC2interactor60.600201.908ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
28 HTRA2suppressor31.0000Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
29 INTS4P2interactor100NA
30 KIF22interactor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
31 KIF23interactor30.6671.000DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
32 LLGL2interactor200Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
33 MCPH1suppressor30.6671.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
MSP (PF01716, IPR002628): Manganese-stabilising protein / photosystem II polypeptide
Spectrin (PF00435, IPR002017): Spectrin repeat
Microcephalin (PF12258, IPR022047): Microcephalin protein
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
34 MOSoncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
35 MYH13interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
36 MYO18Ainteractor30.6671.400Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
37 PLK1suppressor30.6678.083Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
38 PRSS45interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
39 RASSF2suppressor100RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
40 RIC3interactor21.0000CHASE3 (PF05227, IPR007891): CHASE3 domain
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
41 RNF41interactor31.0000Sina (PF03145, IPR018121): Seven in absentia protein family
USP8_interact (PF08941, IPR015036): USP8 interacting
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
42 RPGRoncoprotein100PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
Kelch_4 (PF13418): Galactose oxidase, central domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
43 RTBDNinteractor100Folate_rec (PF03024, IPR018143): Folate receptor family
Serglycin (PF04360, IPR007455): Serglycin
44 SIRT7interactor50.60012.687DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
45 SLC30A5oncoprotein70.28615.000Cation_efflux (PF01545, IPR002524): Cation efflux family
DUF4199 (PF13858, IPR025250): Protein of unknown function (DUF4199)
46 SPECC1Linteractor50.300478.864CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
DUF4763 (PF15960, IPR031883): Domain of unknown function (DUF4763)
47 TBC1D22Ainteractor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
48 TCTN3interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
49 TEX35interactor100Tsc35 (PF15079, IPR027874): Testis-specific protein 35
50 TMEM17interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
51 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
52 TP53suppressor120.255504.378DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
53 UBCprotein found in more fusions110.311341.890ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
54 UBE2D1interactor60.50013.638UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
55 UNKinteractor30.333161.129MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
56 USP8interactor60.40019.060DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
57 VAV2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
58 VEGFDinteractor100CXCXC (PF03128, IPR004153): CXCXC repeat
PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
59 WDR4interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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