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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HMBS, SLC24A3 (from a repository: Wed Sep 18 07:32:52 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins3 (21.43 %)
The number (and %) of the tumor suppressors1 (7.14 %)
Total number of binary PPIs (saturation %)24 (26.37 %)
The number (and %) of affected PPIs12 (50.00 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.714
Assortativity coefficient-0.3632
The network average Clustering coefficient0.441
The number (and %) of a zero Clustering coefficients6 (42.86 %)
The number (and %) of a zero Betweenness Centrality11 (78.57 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions EWSR1 (see 1 fusions); APP (see 5 fusions); ZDHHC17 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC24A3interactor000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Na_Ca_ex (PF01699, IPR004837): Sodium/calcium exchanger protein
NOA36 (PF06524, IPR010531): NOA36 protein
SPC25 (PF06703, IPR009582): Microsomal signal peptidase 25 kDa subunit (SPC25)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
2 HMBSparental protein120.106107.000Porphobil_deam (PF01379, IPR022417): Porphobilinogen deaminase, dipyromethane cofactor binding domain
Porphobil_deamC (PF03900, IPR022418): Porphobilinogen deaminase, C-terminal domain
3 APPprotein found in more fusions70.4009.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
5 GABREinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
6 HNRNPA1interactor50.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
7 NPEPL1interactor100Peptidase_M17 (PF00883, IPR000819): Cytosol aminopeptidase family, catalytic domain
8 PDIA3interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
9 RANBP9suppressor31.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
10 SAR1Ainteractor21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
11 TP53I3interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
HupF_HypC (PF01455, IPR001109): HupF/HypC family
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
12 UMPSinteractor100OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
13 YTHDF2interactor31.0000YTH (PF04146, IPR007275): YT521-B-like domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
14 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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