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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZNFX1, ZNF345 (from a repository: Fri Jul 26 03:45:45 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins7 (28.00 %)
The number (and %) of the tumor suppressors1 (4.00 %)
Total number of binary PPIs (saturation %)33 (11.00 %)
The number (and %) of affected PPIs23 (69.70 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI2.240
Assortativity coefficient-0.6385
The network average Clustering coefficient0.227
The number (and %) of a zero Clustering coefficients18 (72.00 %)
The number (and %) of a zero Betweenness Centrality23 (92.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZNF345,ZNFX1 All fusions
Proteins found in more fusions FYN (see 1 fusions); ZNFX1/CSDE1 (see 1 fusions); MIEF1 (see 1 fusions); ZNFX1/DDX27 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZNF345interactor000NA
2 ZNFX1parental protein230.020494.000zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
3 AMZ2interactor100Peptidase_M10 (PF00413, IPR001818): Matrixin
Peptidase_M54 (PF07998, IPR012962): Peptidase family M54
4 CDK4oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
5 CSDE1oncoprotein21.0000CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
SUZ-C (PF12901, IPR024642): SUZ-C motif
S1-like (PF14444, IPR025223): S1-like
6 CXXC4suppressor100Glycoprotein_G (PF00802, IPR000925): Pneumovirus attachment glycoprotein G
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
7 DDX27protein found in more fusions100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
8 DRC1interactor100GvpK (PF05121, IPR007805): Gas vesicle protein K
Octopine_DH (PF02317, IPR003421): NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
ApoO (PF09769, IPR019166): Apolipoprotein O
NYD-SP28 (PF14772): Sperm tail
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
LRR19-TM (PF15176): Leucine-rich repeat family 19 TM domain
9 DROSHAinteractor31.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
10 ENO1oncoprotein21.0000Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
11 FYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 HSF2interactor100HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
13 IMP3interactor100Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain
S4 (PF01479, IPR002942, SM00363): S4 domain
14 LACTBoncoprotein200Beta-lactamase (PF00144, IPR001466): Beta-lactamase
15 MIEF1protein found in more fusions200Mab-21 (PF03281, IPR024810): Mab-21 protein
16 MOV10interactor100AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
17 NXF1interactor41.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
18 PCDH1interactor100Cadherin_2 (PF08266, IPR013164): Cadherin-like
Protocadherin (PF08374, IPR013585): Protocadherin
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
RGCC (PF15151, IPR029252): Response gene to complement 32 protein family
Cadherin_3 (PF16184): Cadherin-like
19 PDK1interactor200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
20 SCAF11interactor100DUF566 (PF04484, IPR007573): Family of unknown function (DUF566)
Phage_XkdX (PF09693, IPR010022): Phage uncharacterised protein (Phage_XkdX)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
21 SHMT2interactor100SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
22 SS18L2interactor100SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
23 TUBA1Cinteractor100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
24 UGGT1interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
25 XPO1interactor40.6672.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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