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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TWSG1, ZNF254 (from a repository: Sat Aug 3 00:55:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)7
The number (and %) of the onco-proteins0 (0.00 %)
The number (and %) of the tumor suppressors1 (14.29 %)
Total number of binary PPIs (saturation %)5 (23.81 %)
The number (and %) of affected PPIs5 (100.00 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI1.429
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients7 (100.00 %)
The number (and %) of a zero Betweenness Centrality6 (85.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TWSG1,ZNF254 All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TWSG1parental protein5020.000Tsg (PF04668, IPR006761): Twisted gastrulation (Tsg) protein conserved region
2 ZNF254interactor000KRAB (PF01352, IPR001909, SM00349): KRAB box
ROS_MUCR (PF05443, IPR008807): ROS/MUCR transcriptional regulator protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
LCE (PF14672, IPR028205): Late cornified envelope
zn-ribbon_14 (PF16503, IPR032442): Zinc-ribbon
3 BMP4suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
4 CHRDinteractor100CHRD (PF07452, IPR010895, SM00754): CHRD domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
5 MOV10interactor100AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
6 SGTAinteractor100TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
7 TNS2interactor100PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
PRIMA1 (PF16101): Proline-rich membrane anchor 1

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