Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SYNGR1, CCNL1 (from a repository: Tue Jul 30 21:25:30 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins2 (15.38 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)18 (23.08 %)
The number (and %) of affected PPIs11 (61.11 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI2.462
Assortativity coefficient-0.0913
The network average Clustering coefficient0.344
The number (and %) of a zero Clustering coefficients7 (53.85 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SYNGR1,CCNL1 All fusions
Proteins found in more fusions APP (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SYNGR1parental protein3042.000MARVEL (PF01284, IPR008253): Membrane-associating domain
2 CCNL1parental protein80.14396.000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
3 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 APPBP2interactor30.33364.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
5 CDK11Aoncoprotein31.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
6 CREB3interactor3054.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
7 CSNK2A2interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
8 FATE1interactor100Miff (PF05644, IPR008518): Mitochondrial and peroxisomal fission factor Mff
9 HMOX2interactor100Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
10 ISG15suppressor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
11 JMJD6interactor100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
12 RNPS1interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
13 TFIP11interactor100G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal

B a c k    t o    T o p ⇑