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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SYNGR1, CCNL1 (from a repository: Tue Jul 30 21:25:30 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins2 (15.38 %)
The number (and %) of the tumor suppressors1 (7.69 %)
Total number of binary PPIs (saturation %)18 (23.08 %)
The number (and %) of affected PPIs11 (61.11 %)
The number of possible different fusions2
PPI diameter5
PPI radius3
The average degree of PPI2.462
Assortativity coefficient-0.0913
The network average Clustering coefficient0.344
The number (and %) of a zero Clustering coefficients7 (53.85 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)


List of the fusions

PPI for parental proteins: SYNGR1,CCNL1 All fusions
Proteins found in more fusions APP (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SYNGR1parental protein3042.000MARVEL (PF01284, IPR008253): Membrane-associating domain
2 CCNL1parental protein80.14396.000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936)
3 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 APPBP2interactor30.33364.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
5 CDK11Aoncoprotein31.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
6 CREB3interactor3054.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
7 CSNK2A2interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
8 FATE1interactor100Miff (PF05644, IPR008518): Mitochondrial and peroxisomal fission factor Mff
9 HMOX2interactor100Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
10 ISG15suppressor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
11 JMJD6interactor100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
12 RNPS1interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
13 TFIP11interactor100G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal

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