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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins C5orf42, TULP4 (from a repository: Mon Aug 20 22:27:54 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins3 (37.50 %)
The number (and %) of the tumor suppressors1 (12.50 %)
Total number of binary PPIs (saturation %)14 (50.00 %)
The number (and %) of affected PPIs6 (42.86 %)
The number of possible different fusions2
PPI diameter4
PPI radius2
The average degree of PPI2.500
Assortativity coefficient-0.3363
The network average Clustering coefficient0.479
The number (and %) of a zero Clustering coefficients2 (25.00 %)
The number (and %) of a zero Betweenness Centrality4 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: C5orf42,TULP4 All fusions
Proteins found in more fusions SRPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 C5orf42parental protein40.16722.000Joubert (PF15392, IPR028236): Joubert syndrome-associated
2 TULP4parental protein21.0000Tub (PF01167, IPR000007): Tub family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Mif2_N (PF15624, IPR028929): Kinetochore CENP-C fungal homologue, Mif2, N-terminal
SOCS_box (PF07525, IPR001496): SOCS box
3 CAND1interactor50.33324.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
4 CUL5suppressor30.6675.000Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
5 ELAVL1oncoprotein40.6675.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 PAK1oncoprotein200PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
7 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
8 TUBGCP4interactor100Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family

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