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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LOC105378866, C21orf59 (from a repository: Thu Jun 20 06:23:26 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins9 (25.71 %)
The number (and %) of the tumor suppressors2 (5.71 %)
Total number of binary PPIs (saturation %)43 (7.23 %)
The number (and %) of affected PPIs33 (76.74 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI2.057
Assortativity coefficient-0.6242
The network average Clustering coefficient0.095
The number (and %) of a zero Clustering coefficients30 (85.71 %)
The number (and %) of a zero Betweenness Centrality32 (91.43 %)


List of the fusions

PPI for parental proteins: C21orf59,LOC105378866 All fusions
Proteins found in more fusions APP (see 4 fusions); STK3 (see 1 fusions); LYN (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 C21orf59parental protein330.0061048.000BRX (PF08381, IPR013591): Transcription factor regulating root and shoot growth via Pin3
DUF2870 (PF11069, IPR021298): Protein of unknown function (DUF2870)
2 LOC105378866interactor000NA
3 AKR7A2interactor31.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
4 APPprotein found in more fusions40.6671.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ASPRV1interactor100gag-asp_proteas (PF13975): gag-polyprotein putative aspartyl protease
6 BAG3oncoprotein200BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
7 CALML5interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
8 CDSNinteractor200Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
9 CPA4interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
10 DUSP12interactor30.6671.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
11 ECM1oncoprotein100ECM1 (PF05782, IPR008605): Extracellular matrix protein 1 (ECM1)
12 FLGinteractor100Filaggrin (PF03516, IPR003303): Filaggrin
S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
Hid1 (PF12722): High-temperature-induced dauer-formation protein
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
13 GLRXinteractor100Glutaredoxin (PF00462, IPR002109): Glutaredoxin
14 GM2Ainteractor100E1_DerP2_DerF2 (PF02221, IPR003172, SM00737): ML domain
15 HALinteractor100Lyase_aromatic (PF00221, IPR001106): Aromatic amino acid lyase
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
16 HNRNPH1oncoprotein100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
17 ILKAPinteractor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
18 JUPsuppressor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
19 KLK5oncoprotein100Trypsin (PF00089, IPR001254, SM00020): Trypsin
20 LYNoncoprotein200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
21 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
22 MAU2interactor100Cohesin_load (PF10345, IPR019440): Cohesin loading factor
23 NCCRP1interactor100FBA (PF04300, IPR007397): F-box associated region
24 PEX7interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
25 PGAP2interactor100Yip1 (PF04893, IPR006977): Yip1 domain
Frag1 (PF10277, IPR019402): Frag1/DRAM/Sfk1 family
26 PLXNB1oncoprotein100Plexin_cytopl (PF08337, IPR013548): Plexin cytoplasmic RasGAP domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
27 POF1Binteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
28 RNASE7interactor100RnaseA (PF00074, IPR023412, SM00092): Pancreatic ribonuclease
Tr-sialidase_C (PF11052, IPR021287): Trans-sialidase of Trypanosoma hydrophobic C-terminal
29 SERPINA12interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
30 SERPINB2interactor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
31 SERPINB7interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
32 SERPINB8interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
33 STK3protein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
34 TGM1interactor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
35 TGM3suppressor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily

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