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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RELN, TRPS1 (from a repository: Sat Jan 18 08:07:41 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins8 (33.33 %)
The number (and %) of the tumor suppressors3 (12.50 %)
Total number of binary PPIs (saturation %)54 (19.57 %)
The number (and %) of affected PPIs23 (42.59 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.333
Assortativity coefficient-0.3504
The network average Clustering coefficient0.412
The number (and %) of a zero Clustering coefficients8 (33.33 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TRPS1,RELN All fusions
Proteins found in more fusions COPS5 (see 1 fusions); CTBP1 (see 2 fusions); SQSTM1 (see 5 fusions); NLK (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TRPS1parental protein170.103295.833Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
2 RELNparental protein60.100126.000BNR (PF02012, IPR002860): BNR/Asp-box repeat
EB (PF01683, IPR006149): EB module
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
Reeler (PF02014, IPR002861): Reeler domain
3 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
4 CDK2AP1suppressor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
5 CEP170P1interactor200NA
6 COPS5protein found in more fusions40.33352.500JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7 CTBP1protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
8 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
9 FOXJ2interactor100SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
10 HDAC1suppressor60.6006.333FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
11 KRASoncoprotein50.167101.333Ras (PF00071, IPR001806, SM00173): Ras family
12 LRP8interactor100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
13 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
14 MCM6interactor31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
15 NFATC1oncoprotein40.6671.667RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
16 NLKprotein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
17 RNF4interactor41.0000Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
18 SEC16Ainteractor100APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
19 SQSTM1oncoprotein200PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
20 SUMO1interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
21 TEAD2interactor30.33331.667TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
22 TP53BP1suppressor60.26778.33353-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
23 UBE2Iinteractor90.32194.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
24 VLDLRinteractor100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
DUF4010 (PF13194, IPR025105): Domain of unknown function (DUF4010)
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site

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