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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRPSAP1, FOXN3 (from a repository: Sun Aug 25 14:15:03 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins12 (30.00 %)
The number (and %) of the tumor suppressors4 (10.00 %)
Total number of binary PPIs (saturation %)96 (12.31 %)
The number (and %) of affected PPIs39 (40.62 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI4.000
Assortativity coefficient-0.3855
The network average Clustering coefficient0.353
The number (and %) of a zero Clustering coefficients16 (40.00 %)
The number (and %) of a zero Betweenness Centrality19 (47.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PRPSAP1,FOXN3 All fusions
Proteins found in more fusions COPS5 (see 1 fusions); MAPK1 (see 1 fusions); PRPS2 (see 2 fusions); IVNS1ABP (see 2 fusions); PSPH (see 2 fusions); ILK (see 1 fusions); DDX17 (see 3 fusions); SRPK2 (see 1 fusions); DDX5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PRPSAP1parental protein290.079787.370Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
2 FOXN3parental protein100.022496.833LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
3 ASB18interactor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
4 ASB9interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 CD2BP2interactor21.0000GYF (PF02213, IPR003169, SM00444): GYF domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
6 CHSY1interactor21.0000CHGN (PF05679, IPR008428): Chondroitin N-acetylgalactosaminyltransferase
Fringe (PF02434, IPR003378): Fringe-like
7 CHSY3interactor100CHGN (PF05679, IPR008428): Chondroitin N-acetylgalactosaminyltransferase
Fringe (PF02434, IPR003378): Fringe-like
8 COPS5protein found in more fusions100.306145.336JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9 DDX17protein found in more fusions90.50057.767CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
10 DDX5oncoprotein60.9000.733DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 ELAVL1oncoprotein130.106522.930RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 EXOSC8interactor200RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
13 FBXW11interactor70.40043.700WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
14 FBXW7suppressor31.0000Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
15 FOXO3Binteractor100NA
16 FOXR2interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
17 HRNRinteractor2042.303DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
18 ILKsuppressor70.7334.067Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
19 IVNS1ABPprotein found in more fusions40.66716.533BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
20 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
21 MAPK1oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
22 MEN1suppressor100Menin (PF05053, IPR007747): Menin
23 MMS19interactor40.6671.667DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
24 NUAK1suppressor30.66716.533Pkinase (PF00069, IPR000719): Protein kinase domain
25 PAXIP1interactor40.50037.533BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
26 PLEKHF2interactor2016.533FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
27 PRKRAinteractor200dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
28 PRPS1oncoprotein60.6005.364Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
29 PRPS2protein found in more fusions50.50045.564Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
30 PRPSAP2interactor50.6005.167Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
31 PSPHoncoprotein200Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
32 PTP4A3oncoprotein30.33326.533DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
33 RAPGEF2interactor30.6670.500PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
34 RPL35interactor21.0000Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
35 SMG9interactor100Smg8_Smg9 (PF10220, IPR019354): Smg8_Smg9
36 SRPK2oncoprotein200DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
37 TMBIM4interactor100Presenilin (PF01080, IPR001108): Presenilin
Bax1-I (PF01027, IPR006214): Inhibitor of apoptosis-promoting Bax1
38 UBLCP1interactor100NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
39 XPO1interactor90.36172.867CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
40 YWHAEoncoprotein50.5004.16714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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