Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins CLDN1, PARD3 (from a repository: Sat Apr 8 17:11:31 2017)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 67 The number (and %) of the onco-proteins 18 (26.87 %) The number (and %) of the tumor suppressors 15 (22.39 %) Total number of binary PPIs (saturation %) 292 (13.21 %) The number (and %) of affected PPIs 67 (22.95 %) The number of possible different fusions 15 PPI diameter 4 PPI radius 2 The average degree of PPI 8.030 Assortativity coefficient -0.2742 The network average Clustering coefficient 0.561 The number (and %) of a zero Clustering coefficients 7 (10.45 %) The number (and %) of a zero Betweenness Centrality 17 (25.37 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PARD3,CLDN1	All fusions
Proteins found in more fusions	NECTIN3 (see 1 fusions); SMAD4 (see 2 fusions); CCDC88A (see 3 fusions); YWHAG (see 1 fusions); YWHAZ (see 1 fusions); JAM3 (see 1 fusions); AMOTL2 (see 1 fusions); SIAH1 (see 4 fusions); MARK2 (see 2 fusions); VHL (see 1 fusions); YWHAH (see 2 fusions); SMAD3 (see 3 fusions); HSPA8/HSPD1 (see 1 fusions); PSME3 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PARD3	parental protein	60	0.107	2813.257	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
2	CLDN1	parental protein	7	0.190	162.871	PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
3	AMOT	oncoprotein	13	0.485	22.367	FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
4	AMOTL2	protein found in more fusions	8	0.714	8.050	HOOK (PF05622, IPR008636): HOOK protein SlyX (PF04102, IPR007236): SlyX Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
5	ANP32E	interactor	2	1.000	0	BUD22 (PF09073, IPR015158): BUD22 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat
6	ARHGAP17	interactor	5	0.700	2.067	BAR (PF03114, IPR004148, SM00721): BAR domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
7	CCDC88A	protein found in more fusions	5	0.667	1.167	bZIP_1 (PF00170, IPR004827): bZIP transcription factor ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) HOOK (PF05622, IPR008636): HOOK protein Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 KxDL (PF10241, IPR019371): Uncharacterized conserved protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
8	CEP19	interactor	1	0	0	CEP19 (PF14933, IPR029412): CEP19-like protein
9	CLDN3	interactor	2	1.000	0	DUF1218 (PF06749, IPR009606): Protein of unknown function (DUF1218) PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
10	CTNNB1	oncoprotein	11	0.345	35.970	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
11	DCAF7	interactor	10	0.533	15.770	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
12	DRG1	interactor	2	0	7.189	MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase TGS (PF02824, IPR004095): TGS domain MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
13	ECT2	suppressor	6	0.667	1.919	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
14	F11R	interactor	3	0.667	1.900	FixS (PF03597, IPR004714): Cytochrome oxidase maturation protein cbb3-type Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
15	GAB1	oncoprotein	3	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain
16	HSPA6	interactor	2	1.000	0	HSP70 (PF00012, IPR013126): Hsp70 protein
17	HSPA8	oncoprotein	7	0.286	13.500	HSP70 (PF00012, IPR013126): Hsp70 protein
18	HSPD1	suppressor	2	1.000	0	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19	JAM2	interactor	4	1.000	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377) Ig_3 (PF13927): Immunoglobulin domain DUF4307 (PF14155, IPR025443): Domain of unknown function (DUF4307)
20	JAM3	protein found in more fusions	4	1.000	0	Phage_Coat_B (PF05356, IPR008020): Phage Coat protein B V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
21	KPNA4	interactor	1	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
22	LATS1	suppressor	7	0.667	10.451	Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
23	LATS2	suppressor	16	0.371	72.871	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
24	LLGL1	suppressor	7	0.762	2.086	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
25	LNX1	interactor	2	0	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
26	MARK2	protein found in more fusions	13	0.530	23.690	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
27	MMGT1	interactor	3	0.667	1.000	MMgT (PF10270, IPR018937): Membrane magnesium transporter
28	NECTIN3	protein found in more fusions	2	0	0	Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2 C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
29	PARD6A	interactor	14	0.451	45.628	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
30	PARD6B	interactor	10	0.689	6.555	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
31	PARD6G	interactor	9	0.611	7.621	PB1 (PF00564, IPR000270, SM00666): PB1 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
32	PATJ	oncoprotein	9	0.472	148.140	L27_2 (PF09045, IPR015132): L27_2 PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
33	PFKP	interactor	1	0	0	PFK (PF00365, IPR000023): Phosphofructokinase Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
34	PNMA1	oncoprotein	4	0.833	0.500	PNMA (PF14893, IPR026523): PNMA
35	PNMA2	interactor	5	0.500	2.984	PNMA (PF14893, IPR026523): PNMA
36	PPP1CA	suppressor	12	0.394	30.435	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
37	PRKCI	interactor	18	0.366	93.595	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
38	PRKCZ	interactor	14	0.487	27.063	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
39	PSMC3	interactor	5	0.500	2.667	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
40	PSME2	interactor	2	0	0	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
41	PSME3	protein found in more fusions	3	1.000	0	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
42	RASSF10	suppressor	4	1.000	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) FliJ (PF02050, IPR012823): Flagellar FliJ protein Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B) PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
43	RASSF7	interactor	7	0.524	8.333	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SlyX (PF04102, IPR007236): SlyX Tryp_alpha_amyl (PF00234, IPR016140, SM00499): Protease inhibitor/seed storage/LTP family ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
44	RASSF8	suppressor	11	0.655	7.037	ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region FliD_C (PF07195, IPR010809): Flagellar hook-associated protein 2 C-terminus PEARLI-4 (PF05278, IPR007942): Arabidopsis phospholipase-like protein (PEARLI 4) RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
45	RASSF9	interactor	4	1.000	0	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB) DUF3087 (PF11286, IPR021438): Protein of unknown function (DUF3087)
46	RPS18	interactor	3	1.000	0	Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
47	RPS3	interactor	5	0.500	5.292	KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
48	SFN	suppressor	12	0.309	145.544	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
49	SIAH1	suppressor	5	0.833	0.400	Sina (PF03145, IPR018121): Seven in absentia protein family
50	SMAD1	interactor	7	0.867	1.248	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
51	SMAD2	suppressor	9	0.607	8.733	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
52	SMAD3	oncoprotein	9	0.679	4.565	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
53	SMAD4	suppressor	7	0.933	0.400	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
54	SMAD7	interactor	7	0.810	1.981	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
55	TJP1	interactor	12	0.197	316.826	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
56	TJP2	oncoprotein	9	0.389	64.129	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
57	TJP3	interactor	3	0.667	0.500	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
58	TMEM17	interactor	6	0.600	4.686	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
59	TP53BP2	suppressor	17	0.390	58.582	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Erp_C (PF06780, IPR009618): Erp protein C-terminus SlyX (PF04102, IPR007236): SlyX SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
60	VAPA	interactor	3	0.667	4.222	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
61	VHL	suppressor	8	0.429	11.000	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
62	YAP1	suppressor	18	0.405	90.010	Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181
63	YWHAB	interactor	12	0.606	20.603	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
64	YWHAE	oncoprotein	15	0.457	36.887	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
65	YWHAG	protein found in more fusions	15	0.549	30.632	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
66	YWHAH	protein found in more fusions	20	0.462	50.557	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
67	YWHAZ	protein found in more fusions	19	0.412	76.521	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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