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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNAJC17, KIAA1217 (from a repository: Fri Sep 14 02:41:09 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)37
The number (and %) of the onco-proteins9 (24.32 %)
The number (and %) of the tumor suppressors2 (5.41 %)
Total number of binary PPIs (saturation %)69 (10.36 %)
The number (and %) of affected PPIs35 (50.72 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.135
Assortativity coefficient-0.2303
The network average Clustering coefficient0.414
The number (and %) of a zero Clustering coefficients14 (37.84 %)
The number (and %) of a zero Betweenness Centrality24 (64.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DNAJC17,KIAA1217 All fusions
Proteins found in more fusions HSBP1 (see 1 fusions); SIAH1 (see 4 fusions); HNRNPLL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DNAJC17parental protein130.077552.190APG6 (PF04111, IPR007243): Autophagy protein Apg6
DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spore_III_AF (PF09581, IPR014245): Stage III sporulation protein AF (Spore_III_AF)
C_Hendra (PF16821, IPR031812): C protein from hendra and measles viruses
2 KIAA1217parental protein220.061782.119AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
3 ABI2suppressor60.40038.964Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
4 C12orf10interactor21.0000UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160)
5 C1orf123interactor21.0000DUF866 (PF05907, IPR008584): Eukaryotic protein of unknown function (DUF866)
6 CNTROBinteractor21.0000DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
7 DHX29interactor100Cytochrom_D1 (PF02239): Cytochrome D1 heme domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
Senescence_reg (PF04520, IPR007608): Senescence regulator
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
8 ELAC2oncoprotein30.6671.000Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease
9 EXOSC5interactor31.0000RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
10 FHL2oncoprotein200LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
11 FXR2interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
12 GCC1interactor40.5003.000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
FAM184 (PF15665): Family with sequence similarity 184, A and B
13 GOLGA2interactor50.6007.750ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
14 HIST1H2BGoncoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15 HNRNPLLprotein found in more fusions200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16 HSBP1protein found in more fusions200HSBP1 (PF06825, IPR009643): Heat shock factor binding protein 1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
17 HSPA14interactor100HSP70 (PF00012, IPR013126): Hsp70 protein
18 HSPA5oncoprotein50.333180.619HSP70 (PF00012, IPR013126): Hsp70 protein
19 HSPA9oncoprotein40.167374.881HSP70 (PF00012, IPR013126): Hsp70 protein
20 HSPH1oncoprotein30.6671.167HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
21 HYOU1interactor30.6679.976HSP70 (PF00012, IPR013126): Hsp70 protein
AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
22 KINinteractor100KOW (PF00467, IPR005824, SM00739): KOW motif
SecM (PF06558, IPR009502): Secretion monitor precursor protein (SecM)
Kin17_mid (PF10357, IPR019447): Domain of Kin17 curved DNA-binding protein
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
23 KRT15interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 MICU2interactor10023S_rRNA_IVP (PF05635, IPR012657): 23S rRNA-intervening sequence protein
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
25 NARSinteractor100tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
26 NCK2interactor40.6671.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 NINLinteractor21.0000PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
28 PTH1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
29 SEC16Ainteractor31.0000APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
30 SHMT2interactor40.167348.595SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
31 SIAH1suppressor200Sina (PF03145, IPR018121): Seven in absentia protein family
32 SORBS3interactor200Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
33 TEX11interactor100SPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
34 TRAF1oncoprotein200HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
35 TRMT6interactor100Gcd10p (PF04189, IPR007316): Gcd10p family
Presenilin (PF01080, IPR001108): Presenilin
INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
36 VPS52interactor31.0000Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
37 XPO1interactor70.333248.738CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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