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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRKY, TEX11 (from a repository: Sat Dec 7 08:26:24 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)59
The number (and %) of the onco-proteins7 (11.86 %)
The number (and %) of the tumor suppressors8 (13.56 %)
Total number of binary PPIs (saturation %)90 (5.26 %)
The number (and %) of affected PPIs57 (63.33 %)
The number of possible different fusions9
PPI diameter4
PPI radius3
The average degree of PPI2.644
Assortativity coefficient-0.7053
The network average Clustering coefficient0.234
The number (and %) of a zero Clustering coefficients39 (66.10 %)
The number (and %) of a zero Betweenness Centrality45 (76.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TEX11,PRKY All fusions
Proteins found in more fusions MAPK9 (see 3 fusions); HSP90AA1 (see 6 fusions); GAPDH/CDKN1A (see 1 fusions); MAPK14 (see 1 fusions); MAD1L1 (see 3 fusions); GAPDH (see 5 fusions); SNW1 (see 1 fusions); BAG2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TEX11parental protein490.0053134.800SPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
2 PRKYparental protein80.25059.933NA
3 ALS2CR11interactor100DUF2680 (PF10925, IPR024485): Protein of unknown function (DUF2680)
ALS2CR11 (PF15729, IPR031462): Amyotrophic lateral sclerosis 2 candidate 11
4 ATXN3interactor31.0000Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
5 BAG2protein found in more fusions31.0000IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
6 BEX1interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
7 BORCS8interactor100NEP (PF10167, IPR019320): Uncharacterised conserved protein
8 BORCS8-MEF2Boncoprotein100Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
9 C10orf82interactor100DUF2475 (PF10629, IPR018902): Protein of unknown function (DUF2475)
10 C14orf105interactor21.0000DUF4619 (PF15398, IPR029235): Domain of unknown function (DUF4619)
11 C6orf226interactor100DUF4267 (PF14087, IPR025363): Domain of unknown function (DUF4267)
12 CCT3interactor40.83313.167Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CCT6Ainteractor40.83313.167Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14 CDKN1Asuppressor40.333212.333CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
15 CENPPinteractor100CENP-P (PF13096, IPR027801): CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P
16 CFAP53interactor100Rsc14 (PF08586, IPR013895): RSC complex, Rsc14/Ldb7 subunit
YtxH (PF12732, IPR024623): YtxH-like protein
TPH (PF13868): Trichohyalin-plectin-homology domain
17 CLK1interactor31.0000PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
18 COL20A1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
19 CXCL14suppressor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
20 DUSP21interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
21 DUSP6suppressor20102.667DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
22 EFHC1interactor100DUF1126 (PF06565, IPR010554): DUF1126 PH-like domain
NLPC_P60 (PF00877, IPR000064): NlpC/P60 family
EF-hand_6 (PF13405, IPR002048): EF-hand domain
23 FAM156Ainteractor100PGC7_Stella (PF15549, IPR029096): PGC7/Stella/Dppa3 domain
24 FBF1interactor21.0000DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
25 GAPDHoncoprotein40.66715.800Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
26 GATAD2Binteractor100DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
27 HSP90AA1oncoprotein70.333136.567HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
28 HYIinteractor100AP_endonuc_2 (PF01261, IPR013022): Xylose isomerase-like TIM barrel
29 ING3suppressor100PHD (PF00628, IPR019787, SM00249): PHD-finger
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
30 KIAA0408interactor100IncA (PF04156, IPR007285): IncA protein
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
31 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
32 LIN37interactor100LIN37 (PF15306, IPR028226): LIN37
33 MAD1L1suppressor31.0000MAD (PF05557, IPR008672): Mitotic checkpoint protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
34 MAPK14oncoprotein50.167134.000Pkinase (PF00069, IPR000719): Protein kinase domain
35 MAPK9suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
36 MAPKAPK3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
37 MAPKBP1interactor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
38 MYEF2interactor20102.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39 NECAB2interactor200ABM (PF03992, IPR007138): Antibiotic biosynthesis monooxygenase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
40 NEFLinteractor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
NOA36 (PF06524, IPR010531): NOA36 protein
BORG_CEP (PF14957, IPR029273): Cdc42 effector
41 NRIP1oncoprotein100ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
42 POM121interactor100Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
43 PPP1R18interactor30.6671.000Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
44 REXO1L6Pinteractor100NA
45 RIBC1interactor100RIB43A (PF05914, IPR008805): RIB43A
46 RIBC2interactor100RIB43A (PF05914, IPR008805): RIB43A
47 SEPTIN1interactor200Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20
Septin (PF00735, IPR000038): Septin
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
48 SNW1protein found in more fusions70.333425.600SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
49 SNX7interactor100PX (PF00787, IPR001683, SM00312): PX domain
Mit_KHE1 (PF10173, IPR018786): Mitochondrial K+-H+ exchange-related
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
50 SPERTinteractor40.6671.000ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Chibby (PF14645, IPR028118): Chibby family
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
51 STMN2interactor100Stathmin (PF00836, IPR000956): Stathmin family
52 TBC1D22Binteractor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
53 TCHPsuppressor100TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
TPH (PF13868): Trichohyalin-plectin-homology domain
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
54 TCP1interactor50.70015.300Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
55 TIPINinteractor100ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Swi3 (PF07962, IPR012923): Replication Fork Protection Component Swi3
CEP19 (PF14933, IPR029412): CEP19-like protein
56 TSC22D4interactor100AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
57 UTP14Cinteractor100Utp14 (PF04615, IPR006709): Utp14 protein
58 VIL1suppressor100Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
59 ZNF414interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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