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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)73
The number (and %) of the onco-proteins13 (17.81 %)
The number (and %) of the tumor suppressors9 (12.33 %)
Total number of binary PPIs (saturation %)143 (5.44 %)
The number (and %) of affected PPIs71 (49.65 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI3.479
Assortativity coefficient-0.6700
The network average Clustering coefficient0.298
The number (and %) of a zero Clustering coefficients40 (54.79 %)
The number (and %) of a zero Betweenness Centrality48 (65.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TEX11,TRA All fusions
Proteins found in more fusions CD2AP (see 1 fusions); MAD1L1 (see 3 fusions); SYVN1 (see 1 fusions); NCOA6 (see 1 fusions); VCP (see 4 fusions); SH3KBP1 (see 1 fusions); MAPK9 (see 3 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TEX11parental protein490.0054106.925SPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
2 TRAparental protein220.156756.967NA
3 ALS2CR11interactor100DUF2680 (PF10925, IPR024485): Protein of unknown function (DUF2680)
ALS2CR11 (PF15729, IPR031462): Amyotrophic lateral sclerosis 2 candidate 11
4 ATXN3interactor60.500420.667Josephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
5 BAG6interactor80.61930.170DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 BEX1interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
7 BORCS8interactor100NEP (PF10167, IPR019320): Uncharacterised conserved protein
8 BORCS8-MEF2Boncoprotein100Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
9 C10orf82interactor100DUF2475 (PF10629, IPR018902): Protein of unknown function (DUF2475)
10 C14orf105interactor21.0000DUF4619 (PF15398, IPR029235): Domain of unknown function (DUF4619)
11 C6orf226interactor100DUF4267 (PF14087, IPR025363): Domain of unknown function (DUF4267)
12 CD2APprotein found in more fusions31.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
13 CDKN1Asuppressor50.500251.965CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
14 CENPPinteractor100CENP-P (PF13096, IPR027801): CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P
15 CFAP53interactor100Rsc14 (PF08586, IPR013895): RSC complex, Rsc14/Ldb7 subunit
YtxH (PF12732, IPR024623): YtxH-like protein
TPH (PF13868): Trichohyalin-plectin-homology domain
16 CLK1interactor40.333148.454PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
17 COL20A1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
18 CXCL14suppressor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
19 DUSP21interactor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
20 DUSP6suppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
21 EFHC1interactor100DUF1126 (PF06565, IPR010554): DUF1126 PH-like domain
NLPC_P60 (PF00877, IPR000064): NlpC/P60 family
EF-hand_6 (PF13405, IPR002048): EF-hand domain
22 FAM156Ainteractor100PGC7_Stella (PF15549, IPR029096): PGC7/Stella/Dppa3 domain
23 FBF1interactor30.33366.125DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
24 GATAD2Binteractor100DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
25 GET4interactor50.80024.503DUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
26 HLA-Aoncoprotein50.80023.670DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
27 HLA-DRB1interactor31.0000DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
28 HYIinteractor100AP_endonuc_2 (PF01261, IPR013022): Xylose isomerase-like TIM barrel
29 ING3suppressor100PHD (PF00628, IPR019787, SM00249): PHD-finger
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
30 KIAA0408interactor100IncA (PF04156, IPR007285): IncA protein
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
31 KIAA1217interactor100AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
32 LIN37interactor100LIN37 (PF15306, IPR028226): LIN37
33 MAD1L1suppressor31.0000MAD (PF05557, IPR008672): Mitotic checkpoint protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
34 MAPK9suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
35 MAPKBP1interactor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
36 MED1interactor90.60727.569Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
37 MED12oncoprotein61.0000Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
38 MED14interactor70.714363.788Med14 (PF08638, IPR013947): Mediator complex subunit MED14
39 MED16interactor61.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Med16 (PF11635, IPR021665): Mediator complex subunit 16
40 MED17oncoprotein61.0000Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
41 MED24interactor70.76210.333Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
42 MYEF2interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
43 NCOA6oncoprotein31.0000DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Presenilin (PF01080, IPR001108): Presenilin
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
44 NECAB2interactor30416.121ABM (PF03992, IPR007138): Antibiotic biosynthesis monooxygenase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
45 NEFLinteractor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
NOA36 (PF06524, IPR010531): NOA36 protein
BORG_CEP (PF14957, IPR029273): Cdc42 effector
46 NRIP1oncoprotein20141.837ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
47 POM121interactor20180.170Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
48 PPARAsuppressor30.33388.837zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
49 PPP1R18interactor40.333111.128Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
50 REXO1L6Pinteractor100NA
51 RIBC1interactor100RIB43A (PF05914, IPR008805): RIB43A
52 RIBC2interactor100RIB43A (PF05914, IPR008805): RIB43A
53 SEL1Loncoprotein31.0000fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
54 SEPTIN1interactor200Pet20 (PF08692, IPR014804): Mitochondrial protein Pet20
Septin (PF00735, IPR000038): Septin
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
55 SH3KBP1protein found in more fusions40.333126.503Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
56 SNTA1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
57 SNW1protein found in more fusions40.333113.575SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
58 SNX7interactor100PX (PF00787, IPR001683, SM00312): PX domain
Mit_KHE1 (PF10173, IPR018786): Mitochondrial K+-H+ exchange-related
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
59 SPERTinteractor40.6672.337ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Chibby (PF14645, IPR028118): Chibby family
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
60 STMN2interactor100Stathmin (PF00836, IPR000956): Stathmin family
61 SYVN1protein found in more fusions90.464213.872Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
62 TBC1D22Binteractor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF4502 (PF14950, IPR028026): Domain of unknown function (DUF4502)
63 TCHPsuppressor100TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
TPH (PF13868): Trichohyalin-plectin-homology domain
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
64 THRAP3oncoprotein30.33390.454API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
65 TIPINinteractor100ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Swi3 (PF07962, IPR012923): Replication Fork Protection Component Swi3
CEP19 (PF14933, IPR029412): CEP19-like protein
66 TSC22D4interactor100AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
67 UBL4Ainteractor50.60070.908ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
68 USP19interactor31.0000CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
69 UTP14Cinteractor100Utp14 (PF04615, IPR006709): Utp14 protein
70 VCPprotein found in more fusions140.244438.330AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
71 VIL1suppressor2058.791Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
72 YOD1interactor31.0000OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
73 ZNF414interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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