Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAP2K1, PDK2 (from a repository: Sat Sep 23 11:49:10 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)66
The number (and %) of the onco-proteins21 (31.82 %)
The number (and %) of the tumor suppressors7 (10.61 %)
Total number of binary PPIs (saturation %)265 (12.35 %)
The number (and %) of affected PPIs65 (24.53 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI7.152
Assortativity coefficient-0.3007
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients11 (16.67 %)
The number (and %) of a zero Betweenness Centrality24 (36.36 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP2K1,PDK2 All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); KSR1 (see 1 fusions); PTPN11 (see 1 fusions); VCP (see 4 fusions); MAPK1 (see 1 fusions); YWHAZ (see 1 fusions); BRAF (see 3 fusions); MAP3K1 (see 1 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAP2K1parental protein590.0992613.422Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
2 PDK2parental protein60.400254.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
3 ADCK2interactor200ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
4 ARAFoncoprotein80.6436.933Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
5 ARRB2interactor100.6227.557Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 BANPsuppressor40.333121.535DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
7 BRAFoncoprotein160.42940.399Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
8 BRAPinteractor60.9000.500BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
9 BTRConcoprotein150.34156.933WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
10 CEP170P1interactor200NA
11 DCP1Ainteractor40.5001.167DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
12 DGUOKinteractor200dNK (PF01712, IPR002624): Deoxynucleoside kinase
13 DLATinteractor41.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
Stm1_N (PF09598, IPR019084): Stm1
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
14 ELAVL1oncoprotein130.30347.910RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 GRB10oncoprotein40.6670.841BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
16 HNRNPDoncoprotein90.42912.407CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
17 HRASoncoprotein70.4766.817Ras (PF00071, IPR001806, SM00173): Ras family
18 HSPA1Ainteractor60.7331.737HSP70 (PF00012, IPR013126): Hsp70 protein
19 HSPA8oncoprotein90.5837.552HSP70 (PF00012, IPR013126): Hsp70 protein
20 IQGAP1interactor70.6674.033CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
21 KRASoncoprotein90.3939.336Ras (PF00071, IPR001806, SM00173): Ras family
22 KSR1oncoprotein80.66710.995Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
23 KSR2interactor21.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
24 LAMTOR2interactor21.0000Robl_LC7 (PF03259, IPR004942, SM00960): Roadblock/LC7 domain
25 LAMTOR3interactor60.5335.567MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
26 LSP1interactor21.0000Caldesmon (PF02029, IPR006018): Caldesmon
27 MAP2K2interactor140.38536.188Pkinase (PF00069, IPR000719): Protein kinase domain
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
28 MAP3K1oncoprotein100.52811.683zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
29 MAP3K4suppressor50.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pkinase (PF00069, IPR000719): Protein kinase domain
PLU-1 (PF08429, IPR013637): PLU-1-like protein
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
30 MAP3K8suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
IML1 (PF12257, IPR027244): Vacuolar membrane-associated protein Iml1
31 MAPK1oncoprotein180.33187.721Pkinase (PF00069, IPR000719): Protein kinase domain
32 MAPK3oncoprotein140.47431.412Pkinase (PF00069, IPR000719): Protein kinase domain
33 MAPK8oncoprotein130.33338.333DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
34 MAPK8IP3interactor41.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
35 MYConcoprotein180.265409.993HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
36 NFE2L2oncoprotein50.7002.119bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
37 NUFIP1interactor100NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
38 PDHBinteractor60.400347.247Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
39 PDHXinteractor41.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
40 PDK1interactor60.600253.410HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
41 PDLIM5interactor40.5002.167LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
42 PEBP1suppressor31.0000PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
43 PEBP4interactor21.0000PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
44 PLAUinteractor40.6672.467EGF (PF00008, IPR000742, SM00181): EGF-like domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
45 PLIN3interactor40.6673.000Perilipin (PF03036, IPR004279): Perilipin family
46 POC5interactor100vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
47 PPARGsuppressor50.5001.083zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
48 PSMD10interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
49 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
50 RAF1oncoprotein250.293171.868Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
51 RBM33interactor21.0000IncA (PF04156, IPR007285): IncA protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
52 RPEinteractor31.0000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Ribul_P_3_epim (PF00834, IPR000056): Ribulose-phosphate 3 epimerase family
53 SKA3interactor100RNA_pol_RpbG (PF16992, IPR031555): DNA-directed RNA polymerase, subunit G
54 TCTN1interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
55 THOC2interactor100Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
56 UBE2Iinteractor90.35716.063UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
57 VAV1oncoprotein31.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
58 VCPprotein found in more fusions150.46226.062AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
59 VSIG4interactor100EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
60 WDR83interactor70.7622.400WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
61 WNK1interactor100.6118.768SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pkinase (PF00069, IPR000719): Protein kinase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
62 YAP1suppressor60.8670.908Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
63 YWHABinteractor160.45044.02314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
64 YWHAEoncoprotein180.386356.34114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
65 YWHAZprotein found in more fusions130.53020.10514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
66 ZNF277interactor100zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)

B a c k    t o    T o p ⇑