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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)75
The number (and %) of the onco-proteins24 (32.00 %)
The number (and %) of the tumor suppressors9 (12.00 %)
Total number of binary PPIs (saturation %)305 (10.99 %)
The number (and %) of affected PPIs74 (24.26 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI7.280
Assortativity coefficient-0.2626
The network average Clustering coefficient0.457
The number (and %) of a zero Clustering coefficients15 (20.00 %)
The number (and %) of a zero Betweenness Centrality23 (30.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP2K1,ALDH9A1 All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); KSR1 (see 1 fusions); PTPN11 (see 1 fusions); ACAT2 (see 1 fusions); VCP (see 4 fusions); MAPK1 (see 1 fusions); YWHAZ (see 1 fusions); BRAF (see 3 fusions); MAP3K1 (see 1 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAP2K1parental protein590.0992921.500Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
2 ALDH9A1parental protein150.029608.697Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ACAT2protein found in more fusions3012.421Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACOT7interactor21.00004HBT (PF03061, IPR006683): Thioesterase superfamily
NINJA_B (PF16136, IPR032310): Putative nuclear localisation signal
5 ARAFoncoprotein80.6436.448Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
6 ARRB2interactor100.62211.868Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATG101interactor100ATG101 (PF07855, IPR012445): Autophagy-related protein 101
8 BANPsuppressor31.0000DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
9 BCCIPinteractor30.33319.104DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
10 BRAFoncoprotein160.42947.804Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11 BRAPinteractor70.60017.999BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
12 BRCA1suppressor140.192297.859BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
13 BTRConcoprotein160.324118.646WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
14 CEP170P1interactor200NA
15 CIAPIN1interactor200CIAPIN1 (PF05093, IPR007785): Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
16 CRY1interactor70.46779.412DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
17 CUL4Boncoprotein60.26764.859Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
18 DCP1Ainteractor40.5001.238DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
19 DDA1interactor30.66721.009DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
20 DGUOKinteractor200dNK (PF01712, IPR002624): Deoxynucleoside kinase
21 ELAVL1oncoprotein160.210275.701RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
22 GBASinteractor207.048NIPSNAP (PF07978, IPR012577): NIPSNAP
23 GDI1interactor30.6673.767GDI (PF00996, IPR018203): GDP dissociation inhibitor
24 GRB10oncoprotein40.6671.205BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
25 HNRNPDoncoprotein110.35655.693CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
26 HRASoncoprotein70.4767.101Ras (PF00071, IPR001806, SM00173): Ras family
27 HSPA1Ainteractor80.46442.576HSP70 (PF00012, IPR013126): Hsp70 protein
28 HSPA8oncoprotein120.379125.249HSP70 (PF00012, IPR013126): Hsp70 protein
29 IQGAP1interactor80.50061.470CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
30 KRASoncoprotein90.39312.998Ras (PF00071, IPR001806, SM00173): Ras family
31 KSR1oncoprotein80.66714.182Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
32 KSR2interactor21.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
KSR1-SAM (PF13543, IPR025561): SAM like domain present in kinase suppressor RAS 1
33 LAMTOR2interactor21.0000Robl_LC7 (PF03259, IPR004942, SM00960): Roadblock/LC7 domain
34 LAMTOR3interactor60.53310.923MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
35 LSP1interactor21.0000Caldesmon (PF02029, IPR006018): Caldesmon
36 MAP2K2interactor140.38550.510Pkinase (PF00069, IPR000719): Protein kinase domain
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
37 MAP3K1oncoprotein110.48932.048zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
38 MAP3K4suppressor50.6671.068CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pkinase (PF00069, IPR000719): Protein kinase domain
PLU-1 (PF08429, IPR013637): PLU-1-like protein
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
39 MAP3K8suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
IML1 (PF12257, IPR027244): Vacuolar membrane-associated protein Iml1
40 MAPK1oncoprotein190.320133.784Pkinase (PF00069, IPR000719): Protein kinase domain
41 MAPK3oncoprotein150.45156.550Pkinase (PF00069, IPR000719): Protein kinase domain
42 MAPK8oncoprotein130.33332.592DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
43 MAPK8IP3interactor41.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
44 MYConcoprotein180.301102.935HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
45 NFE2L2oncoprotein60.53311.212bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
46 NUFIP1interactor206.110NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
47 PDLIM5interactor40.5002.367LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
48 PEBP1suppressor31.0000PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
49 PEBP4interactor21.0000PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
50 PGDoncoprotein30.33386.1146PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
51 PLAUinteractor40.6672.040EGF (PF00008, IPR000742, SM00181): EGF-like domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
52 PLIN3interactor40.6670.762Perilipin (PF03036, IPR004279): Perilipin family
53 POC5interactor100vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
54 PPARGsuppressor50.5002.270zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
55 PSMD10interactor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
56 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
57 RAF1oncoprotein250.293198.197Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
58 RBM33interactor21.0000IncA (PF04156, IPR007285): IncA protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
59 RPEinteractor31.0000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Ribul_P_3_epim (PF00834, IPR000056): Ribulose-phosphate 3 epimerase family
60 SKA3interactor100RNA_pol_RpbG (PF16992, IPR031555): DNA-directed RNA polymerase, subunit G
61 TCTN1interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
62 THOC2interactor100Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
63 TNFAIP3suppressor60.40059.234OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
64 UBE2Iinteractor100.36125.510UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
65 UBXN10interactor207.048UBX (PF00789, IPR001012, SM00166): UBX domain
66 USP46interactor3026.759UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
67 VAV1oncoprotein31.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
68 VCPprotein found in more fusions190.307347.262AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
69 WDR83interactor70.7622.400WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
70 WNK1interactor100.61112.418SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pkinase (PF00069, IPR000719): Protein kinase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
71 YAP1suppressor60.8671.218Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
72 YWHABinteractor200.321388.66114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
73 YWHAEoncoprotein200.342247.46614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
74 YWHAZprotein found in more fusions160.390110.68614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
75 ZNF277interactor100zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)

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