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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CLP1, MAPK10 (from a repository: Fri Jul 26 20:47:36 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins14 (24.14 %)
The number (and %) of the tumor suppressors9 (15.52 %)
Total number of binary PPIs (saturation %)183 (11.07 %)
The number (and %) of affected PPIs58 (31.69 %)
The number of possible different fusions13
PPI diameter4
PPI radius2
The average degree of PPI5.414
Assortativity coefficient-0.2428
The network average Clustering coefficient0.582
The number (and %) of a zero Clustering coefficients8 (13.79 %)
The number (and %) of a zero Betweenness Centrality24 (41.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAPK10,CLP1 All fusions
Proteins found in more fusions IMPDH2 (see 1 fusions); CREBBP (see 6 fusions); APP (see 5 fusions); MCL1 (see 2 fusions); NUDT21 (see 2 fusions); HCFC1 (see 2 fusions); DDX5 (see 1 fusions); EZR (see 2 fusions); MAPK9 (see 3 fusions); MSN (see 1 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAPK10parental protein430.0851938.592Pkinase (PF00069, IPR000719): Protein kinase domain
2 CLP1parental protein150.171727.308Clp1 (PF06807, IPR010655): Pre-mRNA cleavage complex II protein Clp1
CLP1_N (PF16573, IPR032324): N-terminal beta-sandwich domain of polyadenylation factor
CLP1_P (PF16575, IPR032319): mRNA cleavage and polyadenylation factor CLP1 P-loop
3 AMMECR1interactor21.0000AMMECR1 (PF01871, IPR002733): AMMECR1
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
4 APPprotein found in more fusions100.250509.644APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARRB1interactor60.6676.000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ARRB2interactor50.7004.821Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ATF2oncoprotein80.42920.389bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
8 CCT2interactor70.52449.243Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CCT6Binteractor40.6673.298Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT7interactor70.52449.920Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CDKN1Bsuppressor100CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
12 CDKN2Asuppressor41.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
13 CDKN2Csuppressor30.6672.086Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
14 CEP290interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HemY_N (PF07219, IPR010817): HemY protein N-terminus
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mnd1 (PF03962, IPR005647): Mnd1 family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Sec20 (PF03908, IPR005606): Sec20
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Swi5 (PF07061, IPR010760): Swi5
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
15 CPSF2interactor31.0000RMMBL (PF07521, IPR011108): Zn-dependent metallo-hydrolase RNA specificity domain
Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
16 CPSF6interactor70.47666.087RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 CPSF7interactor40.8330.500CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
18 CREB3interactor40.33320.838bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
19 CREBBPsuppressor100.47265.293Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
20 DDX5oncoprotein80.47692.288DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
21 DUSP1suppressor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
22 DUSP10oncoprotein21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
23 DUSP16interactor31.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
24 ELK1oncoprotein60.6003.058Ets (PF00178, IPR000418, SM00413): Ets-domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
25 EZRprotein found in more fusions40.6671.000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
26 GCH1interactor31.0000GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
27 GTF3C1interactor100B-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
28 HAX1interactor100Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
29 HCFC1protein found in more fusions40.33319.494fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
30 HDAC1suppressor150.330224.875FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
31 HDAC9interactor60.9000.694Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
CEP19 (PF14933, IPR029412): CEP19-like protein
32 HMCN1interactor100A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
Ig_3 (PF13927): Immunoglobulin domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
33 IMPDH2protein found in more fusions200IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
34 JUNoncoprotein120.400116.647bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
35 KIF26Ainteractor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
36 LDHAinteractor50.5002.667Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
37 MAP2K4suppressor90.50035.022Pkinase (PF00069, IPR000719): Protein kinase domain
38 MAPK8IP2interactor70.46728.477BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 MAPK8IP3interactor40.8330.500Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
40 MAPK9suppressor180.228125.383Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
41 MCL1oncoprotein31.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
42 MSNoncoprotein31.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
43 NUDT21protein found in more fusions60.50044.274NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
44 PCF11interactor50.7002.852CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
CFIA_Pcf11 (PF11526, IPR021605): Subunit of cleavage factor IA Pcf11
45 PKMYT1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
46 PLIN2interactor100Perilipin (PF03036, IPR004279): Perilipin family
47 RDXinteractor21.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
48 RELAoncoprotein70.8002.583DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
49 SH3BP5interactor30.6671.558SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5)
50 SNW1protein found in more fusions100.333228.001SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
51 TNIP1interactor200ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
52 TP53suppressor140.346142.607DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
53 TSEN15interactor41.0000Sen15 (PF09631, IPR018593): Sen15 protein
54 TSEN2interactor41.0000tRNA_int_endo (PF01974, IPR006677): tRNA intron endonuclease, catalytic C-terminal domain
tRNA_int_endo_N (PF02778, IPR006678): tRNA intron endonuclease, N-terminal domain
SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
55 TSEN34interactor41.0000Presenilin (PF01080, IPR001108): Presenilin
tRNA_int_endo (PF01974, IPR006677): tRNA intron endonuclease, catalytic C-terminal domain
56 TSEN54interactor50.7003.000tRNA_int_endo_N (PF02778, IPR006678): tRNA intron endonuclease, N-terminal domain
tRNA_int_end_N2 (PF12928, IPR024336): tRNA-splicing endonuclease subunit sen54 N-term
57 UNC119interactor30.6671.000GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
58 WDR62interactor31.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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