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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)188
The number (and %) of the onco-proteins51 (27.13 %)
The number (and %) of the tumor suppressors17 (9.04 %)
Total number of binary PPIs (saturation %)554 (3.15 %)
The number (and %) of affected PPIs187 (33.75 %)
The number of possible different fusions22
PPI diameter5
PPI radius3
The average degree of PPI5.468
Assortativity coefficient-0.5111
The network average Clustering coefficient0.247
The number (and %) of a zero Clustering coefficients104 (55.32 %)
The number (and %) of a zero Betweenness Centrality81 (43.09 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions APP (see 4 fusions); SYK (see 1 fusions); YWHAG (see 1 fusions); MAP3K2 (see 2 fusions); HSP90AA1 (see 2 fusions); UBE2C (see 1 fusions); HSP90AB1 (see 1 fusions); SGK1 (see 2 fusions); PAK4 (see 1 fusions); YWHAH (see 2 fusions); ACTB (see 3 fusions); BAG3 (see 4 fusions); YWHAZ (see 1 fusions); JAM3 (see 1 fusions); FOS (see 4 fusions); PLOD3 (see 2 fusions); CDC37 (see 2 fusions); ATP5A1 (see 1 fusions); PML (see 4 fusions); TP53 (see 3 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAPK7parental protein620.1056932.890Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
2 RHOUparental protein1250.00222997.510Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
3 ACAD8interactor100Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 ACTBoncoprotein60.40042.148Actin (PF00022, IPR004000, SM00268): Actin
5 ACTN4interactor40.33346.309CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
6 ADM2interactor100Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family
7 ALG13interactor100Glyco_tran_28_C (PF04101, IPR007235): Glycosyltransferase family 28 C-terminal domain
OTU (PF02338, IPR003323): OTU-like cysteine protease
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
8 ANGPT4interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
9 ANXA4interactor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
10 ANXA6interactor40.500180.661Annexin (PF00191, IPR018502, SM00335): Annexin
11 AP1S1interactor2047.220Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
12 APPprotein found in more fusions310.0971821.182APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
13 ARHGEF25interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PH_10 (PF15411): Pleckstrin homology domain
SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
14 ARNTLsuppressor2053.420HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
15 AS3MTinteractor100Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
16 ATP5A1protein found in more fusions160.467227.102ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
17 ATP5Linteractor2043.799ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
18 ATP6AP1interactor20165.910ATP-synt_S1 (PF05827, IPR024722): Vacuolar ATP synthase subunit S1 (ATP6S1)
19 BAG3oncoprotein150.341450.196BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
20 BDNFinteractor2036.957NGF (PF00243, IPR002072, SM00140): Nerve growth factor family
21 BNIPLinteractor200BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
22 BRF1suppressor30142.215BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
23 BRINP3interactor100MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
24 C14orf119interactor2047.220DUF4508 (PF14969, IPR028019): Domain of unknown function (DUF4508)
25 C5orf30interactor21.0000UNC119_bdg (PF15435, IPR029219): UNC119-binding protein C5orf30 homologue
26 C8orf59interactor100DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
27 CDC37protein found in more fusions130.56173.890CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
28 CDKL4interactor30.33390.877Pkinase (PF00069, IPR000719): Protein kinase domain
29 CFAP100interactor100DNA_photolyase (PF00875, IPR006050): DNA photolyase
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Peroxin-13_N (PF04088, IPR007223): Peroxin 13, N-terminal region
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
30 CHRNA4interactor20141.739Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
31 CLEC7Ainteractor200Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
32 CPNE3interactor30.33364.705C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
33 CTCFsuppressor100cwf18 (PF08315, IPR013169): cwf18 pre-mRNA splicing factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
34 CUL5suppressor140.363872.008Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
35 DACT2interactor100Dapper (PF15268, IPR024843): Dapper
36 DMRT2interactor100DM (PF00751, IPR001275, SM00301): DM DNA binding domain
TraK (PF06586, IPR010563): TraK protein
37 DNM2interactor40.167200.251Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
38 DOK4interactor2077.996IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
39 DOT1Loncoprotein21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DivIC (PF04977, IPR007060): Septum formation initiator
DOT1 (PF08123, IPR013110): Histone methylation protein DOT1
ZapB (PF06005, IPR009252): Cell division protein ZapB
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
40 DSC1interactor41.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
UPF0114 (PF03350, IPR005134): Uncharacterized protein family, UPF0114
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
41 DSCR8interactor100NA
42 DSG1interactor41.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
43 EGLN3suppressor31.00002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
44 EIF4Binteractor70.533226.285RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609, IPR022251): Wound-induced protein
PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
45 ELP5interactor100Elong_Iki1 (PF10483, IPR019519): Elongator subunit Iki1
46 EMC2interactor2063.055TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
47 ERFsuppressor2047.220CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Ets (PF00178, IPR000418, SM00413): Ets-domain
MCPVI (PF02993, IPR004243): Minor capsid protein VI
48 ERO1Ainteractor2063.055ERO1 (PF04137, IPR007266): Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
49 ESYT1interactor2063.055C2 (PF00168, IPR000008, SM00239): C2 domain
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
50 ETS1oncoprotein40.6672.305Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
51 FAM110Binteractor100FAM110_C (PF14160, IPR025741): Centrosome-associated C terminus
FAM110_N (PF14161, IPR025739): Centrosome-associated N terminus
52 FCHO2interactor2047.220DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
PIN_2 (PF10130, IPR002716): PIN domain
muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain
53 FGF21interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
54 FKBP15interactor2047.220Filament (PF00038, IPR001664): Intermediate filament protein
FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
WH1 (PF00568, IPR000697, SM00461): WH1 domain
SOSSC (PF15925, IPR031821): SOSS complex subunit C
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
55 FOSoncoprotein40.6673.777bZIP_1 (PF00170, IPR004827): bZIP transcription factor
56 FSCN1oncoprotein31.0000Fascin (PF06268, IPR022768): Fascin domain
57 GALNTL5interactor100Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
58 GANABsuppressor40.8330.667Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
59 GAPDHoncoprotein130.60666.064Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
60 GJA1suppressor31.0000Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43)
Connexin (PF00029, IPR013092, SM00037): Connexin
SieB (PF14163, IPR025982): Super-infection exclusion protein B
61 GLI3oncoprotein20116.632zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
62 GOLGB1interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
Tup_N (PF08581, IPR013890): Tup N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
SOGA (PF11365, IPR027881): Protein SOGA
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
CT_C_D (PF02682): Carboxyltransferase domain, subdomain C and D
63 GPRIN2interactor2034.170GRIN_C (PF15235, IPR032745): G protein-regulated inducer of neurite outgrowth C-terminus
64 GPSM3interactor21.0000GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
65 HCAR1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
66 HINT3interactor30142.215DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
67 HIST1H2BMinteractor2036.957Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
68 HSD17B13interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
69 HSP90AA1oncoprotein330.1981434.278HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
70 HSP90AB1oncoprotein210.432256.736HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
71 HSP90B1suppressor60.60033.072CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
72 HSPA4interactor130.487105.734Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
73 HSPA5oncoprotein160.419180.238HSP70 (PF00012, IPR013126): Hsp70 protein
74 ID2oncoprotein4095.027HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
75 IFFO1interactor100Filament (PF00038, IPR001664): Intermediate filament protein
76 IL17Finteractor100IL17 (PF06083, IPR010345): Interleukin-17
77 INSM2interactor100ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
78 JAM3protein found in more fusions200Phage_Coat_B (PF05356, IPR008020): Phage Coat protein B
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
79 JUPsuppressor60.6673.333Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
80 KAAG1interactor100KAAG1 (PF15354, IPR029407): Kidney-associated antigen 1
81 KIAA1191interactor40.16788.088P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
82 KLRC3interactor100UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
83 LANCL2interactor2036.957Glyco_hydro_127 (PF07944, IPR012878): Beta-L-arabinofuranosidase, GH127
LANC_like (PF05147, IPR007822): Lanthionine synthetase C-like protein
84 LARS2interactor2063.055Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
tRNA-synt_1_2 (PF13603, IPR025709): Leucyl-tRNA synthetase, Domain 2
85 LAYNinteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
86 LDHCinteractor100Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
87 LMO7oncoprotein40.167215.847CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF2072 (PF09845, IPR018645): Zn-ribbon containing protein
AAA_23 (PF13476): AAA domain
DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
88 LYL1oncoprotein100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
89 MAP2K5oncoprotein60.8000.874PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
90 MAP3K2protein found in more fusions90.53622.439PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
91 MARCKSsuppressor40.333272.888MARCKS (PF02063, IPR002101): MARCKS family
92 ME3oncoprotein100malic (PF00390, IPR012301): Malic enzyme, N-terminal domain
Malic_M (PF03949, IPR012302, SM00919): Malic enzyme, NAD binding domain
93 MEF2Aoncoprotein50.50014.553TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
94 MEF2Concoprotein30.6671.709SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
95 MEF2Doncoprotein40.66713.696DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
96 MOSoncoprotein2053.420Pkinase (PF00069, IPR000719): Protein kinase domain
97 MRASoncoprotein2084.185Ras (PF00071, IPR001806, SM00173): Ras family
98 MRPL15interactor2063.055Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
99 MYLK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
100 NCR1interactor2036.957Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
101 NFE2L2oncoprotein21.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
102 NPM3interactor30.33371.627Nucleoplasmin (PF03066): Nucleoplasmin
103 NR1H2oncoprotein20116.632zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
104 NR1I2suppressor30.33399.684zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
105 NRBF2interactor21.0000NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
106 NTRK1oncoprotein430.1382740.188I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
107 NXPH4interactor100Neurexophilin (PF06312, IPR026845): Neurexophilin
108 OXCT2interactor200CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
109 P4HTMinteractor100DUF134 (PF02001, IPR002852): Protein of unknown function DUF134
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
110 PAK1oncoprotein70.467302.944PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
111 PAK4protein found in more fusions110.489419.484PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
112 PCDHGA4interactor100Cadherin_2 (PF08266, IPR013164): Cadherin-like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_tail (PF15974, IPR031904): Cadherin C-terminal cytoplasmic tail, catenin-binding region
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
113 PDLIM3interactor2077.996LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
114 PFDN1interactor61.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
115 PFDN2interactor61.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
116 PFDN4interactor61.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
117 PFDN5interactor70.8102.667Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
118 PFDN6interactor61.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
119 PGK1interactor110.455671.818PGK (PF00162, IPR001576): Phosphoglycerate kinase
120 PIP5K1Aoncoprotein2036.957PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
121 PKMoncoprotein150.390325.386PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
122 PLEKinteractor100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PH (PF00169, IPR001849, SM00233): PH domain
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
123 PLOD3protein found in more fusions40.333158.0092OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
124 PMLsuppressor80.333105.844zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
125 POT1interactor140.205675.489POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
126 PPP3CAinteractor40.66723.250Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
127 PRB1interactor100Pro-rich (PF15240, IPR026086): Proline-rich
128 PRKCAinteractor130.212650.088C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
129 PRKCZinteractor100.58345.849PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
130 PRPF18interactor2078.177Prp18 (PF02840, IPR004098): Prp18 domain
PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
131 PSMA4interactor2063.055Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
132 PTPRRinteractor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3149 (PF11346, IPR021494): Protein of unknown function (DUF3149)
133 PXNoncoprotein40.50050.008LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
134 QTRT1interactor100TGT (PF01702, IPR002616): Queuine tRNA-ribosyltransferase
135 RAB40Aoncoprotein30.66753.420Ras (PF00071, IPR001806, SM00173): Ras family
SOCS_box (PF07525, IPR001496): SOCS box
136 RAD51Doncoprotein100Rad51 (PF08423, IPR013632): Rad51
137 RAF1oncoprotein170.408204.649Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
138 RALBP1interactor30.333170.052DDHD (PF02862, IPR004177, SM01127): DDHD domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SlyX (PF04102, IPR007236): SlyX
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
139 RASSF1suppressor40.33384.020RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
140 RPL23AP5interactor100NA
141 RPS15Ainteractor70.429342.517Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
142 RPS17P16interactor100NA
143 S100A4interactor20103.839S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
144 SEC14L4interactor100CRAL_TRIO_N (PF03765, IPR011074, SM01100): CRAL/TRIO, N-terminal domain
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
145 SEMA3Ginteractor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
146 SEPT6oncoprotein30107.113Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
147 SGK1oncoprotein70.7331.770Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
148 SH2D2Ainteractor30.33335.625SH2 (PF00017, IPR000980, SM00252): SH2 domain
149 SIVA1interactor30142.215Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
150 SKIV2Linteractor2063.055DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3516 (PF12029, IPR021904): Domain of unknown function (DUF3516)
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
151 SLC26A1interactor100STAS (PF01740, IPR002645): STAS domain
Sulfate_transp (PF00916, IPR011547): Sulfate permease family
152 SNU13interactor40.6671.516Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
153 SOX4oncoprotein20103.839Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRI (PF15325, IPR028278): Modulator of retrovirus infection
DUF4685 (PF15737, IPR032756): Domain of unknown function (DUF4685)
154 SSC4Dinteractor100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
155 STX16interactor100Erp_C (PF06780, IPR009618): Erp protein C-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
156 SYKsuppressor60.200276.676Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
157 TCN2interactor2036.957Cobalamin_bind (PF01122, IPR002157): Eukaryotic cobalamin-binding protein
DUF4430 (PF14478, IPR027954): Domain of unknown function (DUF4430)
158 TEKT2interactor100Tektin (PF03148, IPR000435): Tektin family
159 TMEM106Ainteractor100DUF1356 (PF07092, IPR009790): Protein of unknown function (DUF1356)
160 TMEM169interactor100TMEM169 (PF15052, IPR029386): TMEM169 protein family
161 TMEM255Binteractor100FAM70 (PF14967, IPR028014): FAM70 protein
162 TP53suppressor240.1581152.842DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
163 TRIM59interactor20103.839zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF4061 (PF13270, IPR025271): Domain of unknown function (DUF4061)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
164 TUBBinteractor190.398313.496Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
165 UBE2Concoprotein31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
166 USP37interactor40.33362.037UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UCH_N (PF16674, IPR032069): N-terminal of ubiquitin carboxyl-terminal hydrolase 37
167 UTP3oncoprotein100Paf1 (PF03985, IPR007133): Paf1
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
Sas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
Sas10 (PF09368, IPR018972): Sas10 C-terminal domain
EF-G-binding_N (PF07299): Elongation factor G-binding protein, N-terminal
168 VBP1interactor70.8102.667Prefoldin (PF02996, IPR004127): Prefoldin subunit
169 VWA5Asuppressor2036.957VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA_3 (PF13768, IPR002035): von Willebrand factor type A domain
170 WNT6oncoprotein100wnt (PF00110, IPR005817, SM00097): wnt family
171 XPAoncoprotein2047.220XPA_C (PF05181, IPR022656): XPA protein C-terminus
XPA_N (PF01286, IPR022652): XPA protein N-terminal
MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
172 XPO1interactor250.1531527.387CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
173 YWHABinteractor170.478137.24814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
174 YWHAEoncoprotein230.356462.48814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
175 YWHAGprotein found in more fusions200.404328.22014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
176 YWHAHprotein found in more fusions120.655130.50314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
177 YWHAZprotein found in more fusions250.304719.48614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
178 ZBED6CLinteractor100NA
179 ZFAND2Binteractor100UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
180 ZFP64oncoprotein100zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
181 ZKSCAN7interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
182 ZNF117interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Tox-MPTase3 (PF15639, IPR028913): Metallopeptidase toxin 3
183 ZNF177interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
184 ZNF20interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
YhfH (PF14149, IPR025432): YhfH-like protein
185 ZNF569oncoprotein100KRAB (PF01352, IPR001909, SM00349): KRAB box
XPA_N (PF01286, IPR022652): XPA protein N-terminal
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
186 ZNF625interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
187 ZNF747interactor2036.957Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
188 ZNF84interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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