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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KLHL7, VPS54 (from a repository: Wed Aug 7 19:42:32 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins6 (27.27 %)
The number (and %) of the tumor suppressors3 (13.64 %)
Total number of binary PPIs (saturation %)62 (26.84 %)
The number (and %) of affected PPIs21 (33.87 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI4.545
Assortativity coefficient-0.4794
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients5 (22.73 %)
The number (and %) of a zero Betweenness Centrality9 (40.91 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KLHL7,VPS54 All fusions
Proteins found in more fusions NUP153 (see 2 fusions); CUL3 (see 1 fusions); SYN1 (see 1 fusions); UBC (see 7 fusions); YWHAZ (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KLHL7parental protein140.192202.800BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
2 VPS54parental protein70.61955.000Vps54 (PF07928, IPR012501): Vps54-like protein
Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
SBP_bac_6 (PF13343): Bacterial extracellular solute-binding protein
YqzH (PF14164, IPR025546): YqzH-like protein
3 BOD1L1interactor21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
COMPASS-Shg1 (PF05205): COMPASS (Complex proteins associated with Set1p) component shg1
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
YqfQ (PF14181, IPR025571): YqfQ-like protein
4 CARNMT1interactor100N2227 (PF07942, IPR012901): N2227-like protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
5 CKAP5interactor200HEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
6 CUL3protein found in more fusions90.50026.800Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 FERMT3interactor100FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
8 MOV10interactor50.60086.400AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
9 NR2C2suppressor200Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
10 NUP153protein found in more fusions50.8333.867Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
11 NUP50interactor40.6672.000NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
12 NXF1interactor70.533106.933NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 RBX1oncoprotein31.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
14 STX6interactor60.400196.400Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
15 SYN1protein found in more fusions200Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
Synapsin_N (PF10581, IPR019736): Synapsin N-terminal
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
16 TSSC1suppressor51.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
17 UBCprotein found in more fusions60.9000.400ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
18 VPS50interactor51.0000Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
19 VPS51interactor60.86715.000DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
Vps51 (PF08700): Vps51/Vps67
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
Sec5 (PF15469): Exocyst complex component Sec5
20 VPS52interactor70.86715.000Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
21 VPS53suppressor70.86715.000Vps53_N (PF04100, IPR007234): Vps53-like, N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
VPS53_C (PF16854, IPR031745): Vacuolar protein sorting-associated protein 53 C-terminus
22 YWHAZprotein found in more fusions60.9000.40014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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