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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KLHL7, BRD1 (from a repository: Mon Sep 10 02:54:54 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins9 (25.71 %)
The number (and %) of the tumor suppressors7 (20.00 %)
Total number of binary PPIs (saturation %)96 (16.13 %)
The number (and %) of affected PPIs34 (35.42 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI4.629
Assortativity coefficient-0.3228
The network average Clustering coefficient0.360
The number (and %) of a zero Clustering coefficients10 (28.57 %)
The number (and %) of a zero Betweenness Centrality10 (28.57 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BRD1,KLHL7 All fusions
Proteins found in more fusions NUP153 (see 2 fusions); YWHAZ (see 1 fusions); CUL3 (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BRD1parental protein200.058536.105PWWP (PF00855, IPR000313, SM00293): PWWP domain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
AAA_23 (PF13476): AAA domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
2 KLHL7parental protein140.192241.888BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
3 BOD1L1interactor21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
COMPASS-Shg1 (PF05205): COMPASS (Complex proteins associated with Set1p) component shg1
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
YqfQ (PF14181, IPR025571): YqfQ-like protein
4 CARNMT1interactor100N2227 (PF07942, IPR012901): N2227-like protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
5 CEP126interactor205.322Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
6 CKAP5interactor4022.894HEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
7 CNTROBinteractor21.0000DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
8 CUL3protein found in more fusions130.273124.134Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
9 FERMT3interactor100FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
10 FEZ1interactor31.0000FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
11 FEZ2interactor21.0000FEZ (PF07763, IPR011680): FEZ-like protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
12 H2AFXsuppressor60.33344.175Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
13 H3F3Aoncoprotein2015.436Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 HIST1H2BGoncoprotein40.33328.992Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15 HIST1H3Ainteractor60.40025.489Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HIST2H3Cinteractor30.6671.167Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
17 IFI16suppressor60.26790.650HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
18 ING4suppressor40.6670.667PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
19 ING5suppressor40.16713.894ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
20 MOV10interactor70.33329.895AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
21 MYH6interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
22 NR2C2suppressor305.286Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23 NUP153protein found in more fusions60.7005.470Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
24 NUP50interactor50.50027.070NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
25 NXF1interactor110.26767.918NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
26 RBX1oncoprotein31.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
27 RPL10suppressor60.33347.188Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
28 S100A4interactor50.10049.231S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
29 SS18L1oncoprotein309.353DUF1313 (PF07011, IPR009741): Protein of unknown function (DUF1313)
SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
30 TAL1oncoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
31 TMPOinteractor100LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
32 UBCprotein found in more fusions70.66716.389ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 VIMsuppressor50.33316.658Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
34 YWHAZprotein found in more fusions100.33389.73114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
35 ZNF512Binteractor30.6671.000YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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