Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins KLHL7, CRKL (from a repository: Tue Sep 4 14:20:53 2018)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 121 The number (and %) of the onco-proteins 49 (40.50 %) The number (and %) of the tumor suppressors 15 (12.40 %) Total number of binary PPIs (saturation %) 612 (8.43 %) The number (and %) of affected PPIs 122 (19.93 %) The number of possible different fusions 31 PPI diameter 4 PPI radius 2 The average degree of PPI 9.322 Assortativity coefficient -0.2857 The network average Clustering coefficient 0.497 The number (and %) of a zero Clustering coefficients 21 (17.36 %) The number (and %) of a zero Betweenness Centrality 36 (29.75 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: KLHL7,CRKL	All fusions
Proteins found in more fusions	PTPN11 (see 1 fusions); BCR/ABL1 (see 183 fusions); SYK (see 1 fusions); LMNA (see 3 fusions); CRY2 (see 3 fusions); GAB2 (see 3 fusions); EPS15 (see 1 fusions); CBL (see 1 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); PDCD6 (see 1 fusions); YY1 (see 2 fusions); WAC (see 3 fusions); NUP153 (see 2 fusions); ERBB3 (see 2 fusions); EDC3 (see 1 fusions); KHDRBS1 (see 1 fusions); ETV6 (see 1 fusions); BAG3 (see 4 fusions); AREL1 (see 1 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); PIK3R1 (see 1 fusions); NEDD9 (see 1 fusions); SHC1 (see 1 fusions); UBC (see 1 fusions); CBLB (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	KLHL7	parental protein	14	0.192	688.579	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_6 (PF13964): Kelch motif
2	CRKL	parental protein	108	0.065	9004.976	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
3	ABL1	oncoprotein	25	0.435	93.511	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4	AOX1	interactor	1	0	0	Ald_Xan_dh_C (PF01315, IPR000674, SM01008): Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Ald_Xan_dh_C2 (PF02738, IPR008274): Molybdopterin-binding domain of aldehyde dehydrogenase CO_deh_flav_C (PF03450, IPR005107, SM01092): CO dehydrogenase flavoprotein C-terminal domain FAD_binding_5 (PF00941, IPR002346): FAD binding domain in molybdopterin dehydrogenase Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain Fer2_2 (PF01799, IPR002888): [2Fe-2S] binding domain
5	APOB	interactor	3	1.000	0	DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081) DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943) Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH) Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
6	AREL1	protein found in more fusions	3	0	2.577	Filamin (PF00630, IPR017868): Filamin/ABP280 repeat HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
7	ARHGAP32	oncoprotein	10	0.711	5.140	PX (PF00787, IPR001683, SM00312): PX domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RPEL (PF02755, IPR004018, SM00707): RPEL repeat SH3_9 (PF14604, IPR001452): Variant SH3 domain
8	ARHGEF5	interactor	4	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_9 (PF14604, IPR001452): Variant SH3 domain ARHGEF5_35 (PF15441, IPR029212): Rho guanine nucleotide exchange factor 5/35
9	BAG3	oncoprotein	8	0.381	48.087	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
10	BCAR1	oncoprotein	13	0.513	22.171	Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
11	BCR	oncoprotein	15	0.524	32.348	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain IQ_SEC7_PH (PF16453, IPR001849): PH domain
12	BIK	suppressor	1	0	0	bcl-2I13 (PF12201, IPR024579): Bcl2-interacting killer, BH3-domain containing
13	BLNK	suppressor	6	0.800	1.943	SH2 (PF00017, IPR000980, SM00252): SH2 domain
14	BOD1L1	interactor	2	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif COMPASS-Shg1 (PF05205): COMPASS (Complex proteins associated with Set1p) component shg1 DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) YqfQ (PF14181, IPR025571): YqfQ-like protein
15	C15orf54	interactor	1	0	0	NA
16	CARNMT1	interactor	1	0	0	N2227 (PF07942, IPR012901): N2227-like protein RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
17	CBL	suppressor	31	0.372	156.641	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
18	CBLB	oncoprotein	15	0.714	13.265	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1
19	CD34	interactor	1	0	0	CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
20	CEP170	interactor	7	0.571	9.348	FHA (PF00498, IPR000253, SM00240): FHA domain DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254) CEP170_C (PF15308, IPR029300): CEP170 C-terminus
21	CKAP5	interactor	5	0	23.760	HEAT (PF02985, IPR000357): HEAT repeat PAS_6 (PF08348, IPR013559): YheO-like PAS domain UME (PF08064, IPR012993, SM00802): UME (NUC010) domain CLASP_N (PF12348, IPR024395): CLASP N terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
22	CLIC4	oncoprotein	6	0.533	5.008	GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
23	CRY2	protein found in more fusions	6	0.500	2.286	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
24	CUL3	protein found in more fusions	23	0.229	313.536	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
25	CUL7	protein found in more fusions	13	0.182	72.515	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
26	DCP1A	interactor	8	0.571	11.482	DCP1 (PF06058, IPR010334): Dcp1-like decapping family mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
27	DCP2	interactor	5	0.700	2.282	DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain NUDIX (PF00293, IPR000086): NUDIX domain
28	DDX6	oncoprotein	9	0.444	20.871	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
29	DOCK1	interactor	4	0.833	0.508	DHR-2 (PF06920, IPR010703): Dock homology region 2 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein TetR_C_8 (PF14278): Transcriptional regulator C-terminal region DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins SH3_9 (PF14604, IPR001452): Variant SH3 domain DOCK_N (PF16172, IPR032376): DOCK N-terminus
30	DOCK2	oncoprotein	4	0.500	2.562	DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins SH3_9 (PF14604, IPR001452): Variant SH3 domain DOCK_N (PF16172, IPR032376): DOCK N-terminus
31	DOCK5	interactor	1	0	0	DHR-2 (PF06920, IPR010703): Dock homology region 2 SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DUF4663 (PF15668, IPR031366): Domain of unknown function (DUF4663) DOCK_N (PF16172, IPR032376): DOCK N-terminus Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
32	DOK1	suppressor	12	0.727	4.837	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
33	DOK2	suppressor	6	0.867	0.615	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
34	EDC3	protein found in more fusions	8	0.667	10.495	FDF (PF09532, IPR019050, SM01199): FDF domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus LSM14 (PF12701, IPR025609): Scd6-like Sm domain Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3 DUF5096 (PF17019, IPR031512): Domain of unknown function (DUF5096)
35	EDC4	interactor	8	0.571	11.900	DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445) SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
36	EGFR	oncoprotein	38	0.255	440.279	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
37	ELAVL1	oncoprotein	21	0.163	258.716	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38	ELMO2	interactor	2	1.000	0	ELMO_CED12 (PF04727, IPR006816): ELMO/CED-12 family DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) PH_12 (PF16457, IPR001849): Pleckstrin homology domain
39	EPOR	oncoprotein	9	0.806	2.139	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
40	EPS15	oncoprotein	8	0.810	4.507	Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
41	ERBB2	oncoprotein	20	0.515	42.906	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
42	ERBB3	oncoprotein	13	0.652	14.274	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
43	ETV6	suppressor	7	0.533	3.448	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
44	FCGR1A	interactor	2	1.000	0	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain PIRT (PF15099, IPR028068): Phosphoinositide-interacting protein family
45	FERMT3	interactor	2	0	3.333	FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
46	GAB1	oncoprotein	10	0.778	4.733	PH (PF00169, IPR001849, SM00233): PH domain
47	GAB2	oncoprotein	12	0.709	7.232	PH (PF00169, IPR001849, SM00233): PH domain Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
48	GAREM1	interactor	3	1.000	0	SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) CABIT (PF12736, IPR025946): Cell-cycle sustaining, positive selection,
49	GORAB	suppressor	1	0	0	Transcrip_act (PF04949, IPR007033): Transcriptional activator Histone_HNS (PF00816, IPR001801): H-NS histone family MIT_C (PF16565, IPR032341): Phospholipase D-like domain at C-terminus of MIT
50	GRB2	oncoprotein	51	0.203	800.095	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
51	GRN	oncoprotein	7	0.476	10.489	Granulin (PF00396, IPR000118, SM00277): Granulin Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
52	HIP1R	interactor	2	1.000	0	ANTH (PF07651, IPR011417): ANTH domain ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Laminin_II (PF06009, IPR010307): Laminin Domain II TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
53	HNRNPH2	interactor	9	0.357	17.270	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
54	HUWE1	oncoprotein	13	0.470	40.401	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
55	IGF1R	oncoprotein	10	0.756	3.876	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain
56	IMPACT	interactor	1	0	0	RWD (PF05773, IPR006575, SM00591): RWD domain UPF0029 (PF01205, IPR001498): Uncharacterized protein family UPF0029
57	INPP5D	interactor	12	0.667	7.877	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain
58	IRS4	interactor	10	0.511	16.948	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain
59	KHDRBS1	protein found in more fusions	9	0.429	19.969	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
60	KIAA0430	interactor	3	0.667	0.600	NYN (PF01936, IPR021139): NYN domain FlbD (PF06289, IPR009384): Flagellar protein (FlbD) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1 OST-HTH (PF12872, IPR025605): OST-HTH/LOTUS domain
61	KIT	oncoprotein	12	0.667	6.358	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
62	LAMA5	interactor	1	0	0	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Laminin_B (PF00052, IPR000034): Laminin B (Domain IV) Laminin_G_2 (PF02210, IPR001791): Laminin G domain Laminin_I (PF06008, IPR009254): Laminin Domain I Laminin_II (PF06009, IPR010307): Laminin Domain II Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
63	LMNA	protein found in more fusions	10	0.333	90.891	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
64	LTBP4	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain TB (PF00683, IPR017878): TB domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EGF_3 (PF12947, IPR024731): EGF domain
65	MAP4K1	suppressor	7	0.467	47.751	CNH (PF00780, IPR001180, SM00036): CNH domain Pkinase (PF00069, IPR000719): Protein kinase domain
66	MAP4K5	interactor	4	1.000	0	CNH (PF00780, IPR001180, SM00036): CNH domain Pkinase (PF00069, IPR000719): Protein kinase domain
67	MCM2	oncoprotein	14	0.308	57.076	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
68	MEGF6	interactor	2	1.000	0	DSL (PF01414, IPR001774, SM00051): Delta serrate ligand EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Fer4_3 (PF12798, IPR001450): 4Fe-4S binding domain FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
69	MOV10	interactor	17	0.235	237.790	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
70	MPZL1	interactor	3	1.000	0	Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2 FTR1 (PF03239, IPR004923): Iron permease FTR1 family Trp_oprn_chp (PF09534, IPR019051): Tryptophan-associated transmembrane protein (Trp_oprn_chp) V-set (PF07686, IPR013106): Immunoglobulin V-set domain
71	MSL1	interactor	3	0.667	0.143	Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein PEHE (PF15275, IPR029332): PEHE domain MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
72	NEDD9	protein found in more fusions	6	0.800	0.571	Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) SH3_9 (PF14604, IPR001452): Variant SH3 domain
73	NINL	interactor	4	0.333	29.794	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat TBCA (PF02970, IPR004226): Tubulin binding cofactor A DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
74	NOTCH2	suppressor	1	0	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
75	NR2C2	suppressor	2	0	0	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
76	NTRK1	oncoprotein	46	0.192	920.994	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77	NUP153	protein found in more fusions	7	0.467	24.894	Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
78	NUP50	interactor	6	0.467	118.014	NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa) Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
79	NXF1	interactor	23	0.156	385.809	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
80	ODF2	interactor	3	0.667	0.722	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 (PF09134, IPR015217): Invasin, domain 3 Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H) CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
81	OGT	interactor	5	0.700	0.786	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41 TPR_19 (PF14559): Tetratricopeptide repeat
82	OTUB1	interactor	4	0.500	3.303	Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
83	PDCD6	oncoprotein	10	0.333	188.468	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
84	PDGFRA	oncoprotein	9	0.750	3.165	Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain LAT (PF15234, IPR008359): Linker for activation of T-cells
85	PEAK1	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
86	PHC2	interactor	4	1.000	0	SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit zf-CGNR (PF11706, IPR021005): CGNR zinc finger DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692) PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
87	PIK3R1	oncoprotein	31	0.402	124.784	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
88	PIK3R2	oncoprotein	21	0.514	53.805	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
89	PLEKHA1	interactor	2	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain
90	PLSCR1	interactor	4	0.667	2.333	Scramblase (PF03803, IPR005552): Scramblase
91	PNRC1	interactor	4	0.667	1.000	PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
92	POLR1D	interactor	3	1.000	0	RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
93	PPFIBP2	interactor	1	0	0	DASH_Dad1 (PF08649, IPR013958): DASH complex subunit Dad1 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
94	PRR3	interactor	2	1.000	0	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
95	PTEN	suppressor	10	0.267	20.979	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
96	PTPN11	suppressor	23	0.433	68.902	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
97	PXN	oncoprotein	13	0.359	32.878	LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family
98	RAPGEF1	oncoprotein	10	0.578	9.404	RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
99	RBX1	oncoprotein	6	0.400	33.230	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
100	RIN3	interactor	1	0	0	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4 SH2 (PF00017, IPR000980, SM00252): SH2 domain VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
101	RPL31	interactor	6	0.467	8.708	Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
102	SEPHS1	interactor	6	0.500	7.465	AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
103	SGK223	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Serglycin (PF04360, IPR007455): Serglycin
104	SHANK3	interactor	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
105	SHC1	oncoprotein	30	0.347	157.299	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
106	SOCS1	suppressor	12	0.500	17.191	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
107	SOS1	oncoprotein	10	0.889	0.935	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
108	STAT5A	suppressor	7	0.867	0.521	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
109	SYK	suppressor	15	0.560	23.450	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
110	TELO2	interactor	3	1.000	0	Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein HEAT_2 (PF13646): HEAT repeats
111	TMEM168	interactor	1	0	0	COX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII Tweety (PF04906, IPR006990): Tweety UPF0233 (PF06781, IPR009619): Uncharacterised protein family (UPF0233) DUF2085 (PF09858, IPR019206): Predicted membrane protein (DUF2085)
112	TNS2	interactor	4	0.667	1.000	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) cEGF (PF12662, IPR026823): Complement Clr-like EGF-like PRIMA1 (PF16101): Proline-rich membrane anchor 1
113	TRAP1	oncoprotein	7	0.619	7.155	HSP90 (PF00183, IPR001404): Hsp90 protein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
114	TYK2	interactor	6	0.400	3.390	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
115	UBC	protein found in more fusions	22	0.295	217.092	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
116	UBL5	interactor	1	0	0	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
117	USP7	oncoprotein	13	0.394	34.248	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
118	WAC	protein found in more fusions	2	0	0	DUF1319 (PF07028, IPR010746): Protein of unknown function (DUF1319) MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin WW (PF00397, IPR001202, SM00456): WW domain MDFI (PF15316, IPR026134): MyoD family inhibitor CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
119	WAS	oncoprotein	6	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif PRIMA1 (PF16101): Proline-rich membrane anchor 1
120	YWHAZ	protein found in more fusions	19	0.320	154.868	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
121	YY1	protein found in more fusions	4	0.667	0.500	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail

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