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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KLHL7, CRKL (from a repository: Tue Sep 4 14:20:53 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)121
The number (and %) of the onco-proteins49 (40.50 %)
The number (and %) of the tumor suppressors15 (12.40 %)
Total number of binary PPIs (saturation %)612 (8.43 %)
The number (and %) of affected PPIs122 (19.93 %)
The number of possible different fusions31
PPI diameter4
PPI radius2
The average degree of PPI9.322
Assortativity coefficient-0.2857
The network average Clustering coefficient0.497
The number (and %) of a zero Clustering coefficients21 (17.36 %)
The number (and %) of a zero Betweenness Centrality36 (29.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KLHL7,CRKL All fusions
Proteins found in more fusions PTPN11 (see 1 fusions); BCR/ABL1 (see 183 fusions); SYK (see 1 fusions); LMNA (see 3 fusions); CRY2 (see 3 fusions); GAB2 (see 3 fusions); EPS15 (see 1 fusions); CBL (see 1 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); PDCD6 (see 1 fusions); YY1 (see 2 fusions); WAC (see 3 fusions); NUP153 (see 2 fusions); ERBB3 (see 2 fusions); EDC3 (see 1 fusions); KHDRBS1 (see 1 fusions); ETV6 (see 1 fusions); BAG3 (see 4 fusions); AREL1 (see 1 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); PIK3R1 (see 1 fusions); NEDD9 (see 1 fusions); SHC1 (see 1 fusions); UBC (see 1 fusions); CBLB (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KLHL7parental protein140.192688.579BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
2 CRKLparental protein1080.0659004.976SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
3 ABL1oncoprotein250.43593.511Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 AOX1interactor100Ald_Xan_dh_C (PF01315, IPR000674, SM01008): Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
Ald_Xan_dh_C2 (PF02738, IPR008274): Molybdopterin-binding domain of aldehyde dehydrogenase
CO_deh_flav_C (PF03450, IPR005107, SM01092): CO dehydrogenase flavoprotein C-terminal domain
FAD_binding_5 (PF00941, IPR002346): FAD binding domain in molybdopterin dehydrogenase
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fer2_2 (PF01799, IPR002888): [2Fe-2S] binding domain
5 APOBinteractor31.0000DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
6 AREL1protein found in more fusions302.577Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
7 ARHGAP32oncoprotein100.7115.140PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
8 ARHGEF5interactor41.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
ARHGEF5_35 (PF15441, IPR029212): Rho guanine nucleotide exchange factor 5/35
9 BAG3oncoprotein80.38148.087BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
10 BCAR1oncoprotein130.51322.171Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
11 BCRoncoprotein150.52432.348Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
12 BIKsuppressor100bcl-2I13 (PF12201, IPR024579): Bcl2-interacting killer, BH3-domain containing
13 BLNKsuppressor60.8001.943SH2 (PF00017, IPR000980, SM00252): SH2 domain
14 BOD1L1interactor21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
COMPASS-Shg1 (PF05205): COMPASS (Complex proteins associated with Set1p) component shg1
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
YqfQ (PF14181, IPR025571): YqfQ-like protein
15 C15orf54interactor100NA
16 CARNMT1interactor100N2227 (PF07942, IPR012901): N2227-like protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
17 CBLsuppressor310.372156.641Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
18 CBLBoncoprotein150.71413.265Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
19 CD34interactor100CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
20 CEP170interactor70.5719.348FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
21 CKAP5interactor5023.760HEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
22 CLIC4oncoprotein60.5335.008GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
23 CRY2protein found in more fusions60.5002.286DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
24 CUL3protein found in more fusions230.229313.536Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
25 CUL7protein found in more fusions130.18272.515ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
26 DCP1Ainteractor80.57111.482DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
27 DCP2interactor50.7002.282DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
28 DDX6oncoprotein90.44420.871DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
29 DOCK1interactor40.8330.508DHR-2 (PF06920, IPR010703): Dock homology region 2
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
TetR_C_8 (PF14278): Transcriptional regulator C-terminal region
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DOCK_N (PF16172, IPR032376): DOCK N-terminus
30 DOCK2oncoprotein40.5002.562DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DOCK_N (PF16172, IPR032376): DOCK N-terminus
31 DOCK5interactor100DHR-2 (PF06920, IPR010703): Dock homology region 2
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DUF4663 (PF15668, IPR031366): Domain of unknown function (DUF4663)
DOCK_N (PF16172, IPR032376): DOCK N-terminus
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
32 DOK1suppressor120.7274.837IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
33 DOK2suppressor60.8670.615IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
34 EDC3protein found in more fusions80.66710.495FDF (PF09532, IPR019050, SM01199): FDF domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
LSM14 (PF12701, IPR025609): Scd6-like Sm domain
Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3
DUF5096 (PF17019, IPR031512): Domain of unknown function (DUF5096)
35 EDC4interactor80.57111.900DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
36 EGFRoncoprotein380.255440.279Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
37 ELAVL1oncoprotein210.163258.716RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38 ELMO2interactor21.0000ELMO_CED12 (PF04727, IPR006816): ELMO/CED-12 family
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
39 EPORoncoprotein90.8062.139EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
40 EPS15oncoprotein80.8104.507Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
41 ERBB2oncoprotein200.51542.906Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
42 ERBB3oncoprotein130.65214.274Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
43 ETV6suppressor70.5333.448Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
44 FCGR1Ainteractor21.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
PIRT (PF15099, IPR028068): Phosphoinositide-interacting protein family
45 FERMT3interactor203.333FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
46 GAB1oncoprotein100.7784.733PH (PF00169, IPR001849, SM00233): PH domain
47 GAB2oncoprotein120.7097.232PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
48 GAREM1interactor31.0000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
CABIT (PF12736, IPR025946): Cell-cycle sustaining, positive selection,
49 GORABsuppressor100Transcrip_act (PF04949, IPR007033): Transcriptional activator
Histone_HNS (PF00816, IPR001801): H-NS histone family
MIT_C (PF16565, IPR032341): Phospholipase D-like domain at C-terminus of MIT
50 GRB2oncoprotein510.203800.095SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
51 GRNoncoprotein70.47610.489Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
52 HIP1Rinteractor21.0000ANTH (PF07651, IPR011417): ANTH domain
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
53 HNRNPH2interactor90.35717.270RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
54 HUWE1oncoprotein130.47040.401BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
55 IGF1Roncoprotein100.7563.876fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
56 IMPACTinteractor100RWD (PF05773, IPR006575, SM00591): RWD domain
UPF0029 (PF01205, IPR001498): Uncharacterized protein family UPF0029
57 INPP5Dinteractor120.6677.877Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
58 IRS4interactor100.51116.948CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
59 KHDRBS1protein found in more fusions90.42919.969KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
60 KIAA0430interactor30.6670.600NYN (PF01936, IPR021139): NYN domain
FlbD (PF06289, IPR009384): Flagellar protein (FlbD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
OST-HTH (PF12872, IPR025605): OST-HTH/LOTUS domain
61 KIToncoprotein120.6676.358ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
62 LAMA5interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
63 LMNAprotein found in more fusions100.33390.891Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
64 LTBP4interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TB (PF00683, IPR017878): TB domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
65 MAP4K1suppressor70.46747.751CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
66 MAP4K5interactor41.0000CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
67 MCM2oncoprotein140.30857.076AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
68 MEGF6interactor21.0000DSL (PF01414, IPR001774, SM00051): Delta serrate ligand
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Fer4_3 (PF12798, IPR001450): 4Fe-4S binding domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
69 MOV10interactor170.235237.790AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
70 MPZL1interactor31.0000Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2
FTR1 (PF03239, IPR004923): Iron permease FTR1 family
Trp_oprn_chp (PF09534, IPR019051): Tryptophan-associated transmembrane protein (Trp_oprn_chp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
71 MSL1interactor30.6670.143Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
PEHE (PF15275, IPR029332): PEHE domain
MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
72 NEDD9protein found in more fusions60.8000.571Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
73 NINLinteractor40.33329.794PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
74 NOTCH2suppressor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
75 NR2C2suppressor200Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
76 NTRK1oncoprotein460.192920.994I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77 NUP153protein found in more fusions70.46724.894Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
78 NUP50interactor60.467118.014NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
79 NXF1interactor230.156385.809NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
80 ODF2interactor30.6670.722ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase
Invasin_D3 (PF09134, IPR015217): Invasin, domain 3
Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
81 OGTinteractor50.7000.786TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
82 OTUB1interactor40.5003.303Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
83 PDCD6oncoprotein100.333188.468EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
84 PDGFRAoncoprotein90.7503.165Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
85 PEAK1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
86 PHC2interactor41.0000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
87 PIK3R1oncoprotein310.402124.784RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
88 PIK3R2oncoprotein210.51453.805RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
89 PLEKHA1interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
90 PLSCR1interactor40.6672.333Scramblase (PF03803, IPR005552): Scramblase
91 PNRC1interactor40.6671.000PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
92 POLR1Dinteractor31.0000RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
93 PPFIBP2interactor100DASH_Dad1 (PF08649, IPR013958): DASH complex subunit Dad1
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
94 PRR3interactor21.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
95 PTENsuppressor100.26720.979DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
96 PTPN11suppressor230.43368.902SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
97 PXNoncoprotein130.35932.878LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
98 RAPGEF1oncoprotein100.5789.404RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
99 RBX1oncoprotein60.40033.230zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
100 RIN3interactor100RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
SH2 (PF00017, IPR000980, SM00252): SH2 domain
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
101 RPL31interactor60.4678.708Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
102 SEPHS1interactor60.5007.465AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
103 SGK223interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Serglycin (PF04360, IPR007455): Serglycin
104 SHANK3interactor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
105 SHC1oncoprotein300.347157.299PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
106 SOCS1suppressor120.50017.191SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
107 SOS1oncoprotein100.8890.935Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
108 STAT5Asuppressor70.8670.521SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
109 SYKsuppressor150.56023.450Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
110 TELO2interactor31.0000Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein
HEAT_2 (PF13646): HEAT repeats
111 TMEM168interactor100COX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII
Tweety (PF04906, IPR006990): Tweety
UPF0233 (PF06781, IPR009619): Uncharacterised protein family (UPF0233)
DUF2085 (PF09858, IPR019206): Predicted membrane protein (DUF2085)
112 TNS2interactor40.6671.000PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
PRIMA1 (PF16101): Proline-rich membrane anchor 1
113 TRAP1oncoprotein70.6197.155HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
114 TYK2interactor60.4003.390Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
115 UBCprotein found in more fusions220.295217.092ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
116 UBL5interactor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
117 USP7oncoprotein130.39434.248MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
118 WACprotein found in more fusions200DUF1319 (PF07028, IPR010746): Protein of unknown function (DUF1319)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
WW (PF00397, IPR001202, SM00456): WW domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
119 WASoncoprotein61.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
120 YWHAZprotein found in more fusions190.320154.86814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
121 YY1protein found in more fusions40.6670.500zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail

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