Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRKG1, SHMT1 (from a repository: Fri Jul 26 22:47:59 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins15 (23.44 %)
The number (and %) of the tumor suppressors9 (14.06 %)
Total number of binary PPIs (saturation %)181 (8.98 %)
The number (and %) of affected PPIs63 (34.81 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI5.000
Assortativity coefficient-0.3511
The network average Clustering coefficient0.403
The number (and %) of a zero Clustering coefficients24 (37.50 %)
The number (and %) of a zero Betweenness Centrality27 (42.19 %)


List of the fusions

PPI for parental proteins: SHMT1,PRKG1 All fusions
Proteins found in more fusions APEH (see 1 fusions); SMAD4 (see 3 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); CREB1 (see 1 fusions); MAPK9 (see 3 fusions); ITPA (see 1 fusions); TNNT1 (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 SHMT1parental protein420.0962158.285SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
2 PRKG1parental protein210.0331358.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
3 ANXA7suppressor100Annexin (PF00191, IPR018502, SM00335): Annexin
4 APEHoncoprotein90.6437.852Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
5 ARoncoprotein80.190386.229Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6 ARFIP1interactor50.7002.667Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
7 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
8 ATP6V1C1protein found in more fusions130.62121.307V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
9 C18orf25interactor100RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
10 CARSoncoprotein80.46419.511tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
11 CREB1oncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
12 CTTNoncoprotein100.66710.343FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 DEDDinteractor200DED (PF01335, IPR001875, SM00031): Death effector domain
14 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
15 FAM124Ainteractor100FAM124 (PF15067, IPR029380): FAM124 family
16 FAM129Binteractor60.9330.333PH (PF00169, IPR001849, SM00233): PH domain
17 GARSinteractor70.5717.702HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
18 GSPT2interactor70.9051.149GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
19 GTF2F2interactor30190.510TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
20 GTF2Iinteractor30.66799.462GTF2I (PF02946, IPR004212): GTF2I-like repeat
21 HARSinteractor50.6006.723HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
22 HDAC1suppressor90.179451.431FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23 HECW2interactor3049.222C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
24 HIST1H4Ainteractor60.467142.185CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
25 HSPA1Linteractor100HSP70 (PF00012, IPR013126): Hsp70 protein
26 HSPE1interactor40.5003.000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
27 IDEinteractor100.533211.832Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
28 ITPAprotein found in more fusions31.0000Ham1p_like (PF01725, IPR002637): Ham1 family
29 ITPR1interactor21.0000Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
30 LMO2oncoprotein3099.462CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
31 MAPK9suppressor3053.535Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
32 MCATinteractor100Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
33 MRVI1suppressor21.0000MRVI1 (PF05781, IPR008677): MRVI1 protein
34 NPR1interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
HNOBA (PF07701, IPR011645): Heme NO binding associated
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
35 PAICSinteractor50.5003.000AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
36 PAWRsuppressor110.61819.243ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
37 PBDC1interactor100Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
38 PGK2interactor21.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
39 PIM1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
40 PPATinteractor30.6670.667Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
41 PPP1R12Ainteractor20105.684DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
42 PPP1R12Binteractor100Mem_trans (PF03547, IPR004776): Membrane transport protein
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
43 PRRC1interactor30.6671.000NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
44 PRSS23interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
45 RAF1oncoprotein40.66713.947Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
46 RGS2oncoprotein20140.584RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
47 SELLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
48 SHMT2interactor130.43669.177SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
49 SMAD4suppressor50.333144.159MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
50 SNX2interactor110.58228.283PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
51 SNX6interactor110.60028.551PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
52 STAT1suppressor150.440495.120SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
53 STXBP1interactor100Sec1 (PF00995, IPR001619): Sec1 family
54 SULT1A3interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
55 TBXA2Rinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
56 TNNT1protein found in more fusions200Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
57 TRIM39-RPP21interactor100Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
Amidase_2 (PF01510, IPR002502, SM00644): N-acetylmuramoyl-L-alanine amidase
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
58 TSNprotein found in more fusions70.9330.333Translin (PF01997, IPR002848): Translin family
59 TTC1interactor70.52417.047TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
60 VPS29interactor90.667189.278Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
61 WDR77oncoprotein31.0000LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
62 XPO5suppressor50.400155.186IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
63 ZC3H4interactor100API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
Torus (PF16131, IPR032297): Torus domain
64 ZNF646interactor100zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

B a c k    t o    T o p ⇑