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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PRKG1, SHMT1 (from a repository: Fri Jul 26 22:47:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins15 (23.44 %)
The number (and %) of the tumor suppressors9 (14.06 %)
Total number of binary PPIs (saturation %)181 (8.98 %)
The number (and %) of affected PPIs63 (34.81 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI5.000
Assortativity coefficient-0.3511
The network average Clustering coefficient0.403
The number (and %) of a zero Clustering coefficients24 (37.50 %)
The number (and %) of a zero Betweenness Centrality27 (42.19 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SHMT1,PRKG1 All fusions
Proteins found in more fusions APEH (see 1 fusions); SMAD4 (see 3 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); CREB1 (see 1 fusions); MAPK9 (see 3 fusions); ITPA (see 1 fusions); TNNT1 (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SHMT1parental protein420.0962158.285SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
2 PRKG1parental protein210.0331358.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
3 ANXA7suppressor100Annexin (PF00191, IPR018502, SM00335): Annexin
4 APEHoncoprotein90.6437.852Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
5 ARoncoprotein80.190386.229Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6 ARFIP1interactor50.7002.667Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
7 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
8 ATP6V1C1protein found in more fusions130.62121.307V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
9 C18orf25interactor100RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
10 CARSoncoprotein80.46419.511tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
11 CREB1oncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
12 CTTNoncoprotein100.66710.343FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 DEDDinteractor200DED (PF01335, IPR001875, SM00031): Death effector domain
14 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
15 FAM124Ainteractor100FAM124 (PF15067, IPR029380): FAM124 family
16 FAM129Binteractor60.9330.333PH (PF00169, IPR001849, SM00233): PH domain
17 GARSinteractor70.5717.702HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
18 GSPT2interactor70.9051.149GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
19 GTF2F2interactor30190.510TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
20 GTF2Iinteractor30.66799.462GTF2I (PF02946, IPR004212): GTF2I-like repeat
21 HARSinteractor50.6006.723HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
22 HDAC1suppressor90.179451.431FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23 HECW2interactor3049.222C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
24 HIST1H4Ainteractor60.467142.185CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
25 HSPA1Linteractor100HSP70 (PF00012, IPR013126): Hsp70 protein
26 HSPE1interactor40.5003.000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
27 IDEinteractor100.533211.832Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
28 ITPAprotein found in more fusions31.0000Ham1p_like (PF01725, IPR002637): Ham1 family
29 ITPR1interactor21.0000Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
30 LMO2oncoprotein3099.462CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
31 MAPK9suppressor3053.535Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
32 MCATinteractor100Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
33 MRVI1suppressor21.0000MRVI1 (PF05781, IPR008677): MRVI1 protein
34 NPR1interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
HNOBA (PF07701, IPR011645): Heme NO binding associated
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
35 PAICSinteractor50.5003.000AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
36 PAWRsuppressor110.61819.243ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
37 PBDC1interactor100Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
38 PGK2interactor21.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
39 PIM1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
40 PPATinteractor30.6670.667Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
41 PPP1R12Ainteractor20105.684DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
42 PPP1R12Binteractor100Mem_trans (PF03547, IPR004776): Membrane transport protein
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
43 PRRC1interactor30.6671.000NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
44 PRSS23interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
45 RAF1oncoprotein40.66713.947Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
46 RGS2oncoprotein20140.584RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
47 SELLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
48 SHMT2interactor130.43669.177SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
49 SMAD4suppressor50.333144.159MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
50 SNX2interactor110.58228.283PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
51 SNX6interactor110.60028.551PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
52 STAT1suppressor150.440495.120SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
53 STXBP1interactor100Sec1 (PF00995, IPR001619): Sec1 family
54 SULT1A3interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
55 TBXA2Rinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
56 TNNT1protein found in more fusions200Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
57 TRIM39-RPP21interactor100Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
Amidase_2 (PF01510, IPR002502, SM00644): N-acetylmuramoyl-L-alanine amidase
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
58 TSNprotein found in more fusions70.9330.333Translin (PF01997, IPR002848): Translin family
59 TTC1interactor70.52417.047TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
60 VPS29interactor90.667189.278Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
61 WDR77oncoprotein31.0000LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
62 XPO5suppressor50.400155.186IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
63 ZC3H4interactor100API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
Torus (PF16131, IPR032297): Torus domain
64 ZNF646interactor100zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type

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