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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LOXL2, ACTR10 (from a repository: Wed Aug 7 17:58:36 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)37
The number (and %) of the onco-proteins11 (29.73 %)
The number (and %) of the tumor suppressors3 (8.11 %)
Total number of binary PPIs (saturation %)113 (16.97 %)
The number (and %) of affected PPIs35 (30.97 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI5.676
Assortativity coefficient-0.3214
The network average Clustering coefficient0.670
The number (and %) of a zero Clustering coefficients5 (13.51 %)
The number (and %) of a zero Betweenness Centrality18 (48.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LOXL2,ACTR10 All fusions
Proteins found in more fusions RABEP1 (see 1 fusions); EZH2 (see 1 fusions); KIF11 (see 1 fusions); DCTN1 (see 2 fusions); NAGK (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LOXL2parental protein170.199524.115Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
2 ACTR10parental protein180.261488.290Actin (PF00022, IPR004000, SM00268): Actin
3 ACTR1Ainteractor80.8571.550Actin (PF00022, IPR004000, SM00268): Actin
4 ACTR1Binteractor110.58216.383Actin (PF00022, IPR004000, SM00268): Actin
5 C9orf24interactor21.0000SMRP1 (PF15181, IPR028195): Spermatid-specific manchette-related protein 1
6 CA10interactor21.0000Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
7 CAPZA2interactor90.7783.583F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
8 CSPP1interactor60.9330.250Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
CCDC66 (PF15236): Coiled-coil domain-containing protein 66
9 DCTN1protein found in more fusions100.66737.350Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
10 DCTN2interactor120.61812.050Dynamitin (PF04912): Dynamitin
11 DCTN3interactor100.55690.159Dynactin_p22 (PF07426, IPR009991): Dynactin subunit p22
12 DCTN4interactor80.71451.726Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
13 EZH2suppressor61.0000CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
14 GPS2oncoprotein50.300433.027G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
15 HDAC1suppressor100.667214.070FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
16 HIST1H3Ainteractor80.667180.957Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
17 IDSinteractor21.0000Sulfatase (PF00884, IPR000917): Sulfatase
18 IL12RB1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
19 KIF11protein found in more fusions40.333179.557Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
20 KLK11oncoprotein100Trypsin (PF00089, IPR001254, SM00020): Trypsin
21 KLK5oncoprotein100Trypsin (PF00089, IPR001254, SM00020): Trypsin
22 LMNB1interactor51.0000Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
23 LOC554223interactor21.0000NA
24 MTA1oncoprotein61.0000BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
25 MTA2interactor70.9051.715BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
26 MYO19interactor41.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
27 NAGKprotein found in more fusions31.0000BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
28 ORC6interactor100ORC6 (PF05460, IPR008721): Origin recognition complex subunit 6 (ORC6)
29 PDIA3interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
30 PLAURoncoprotein21.0000Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
31 RABEP1oncoprotein41.0000Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
32 RBBP4oncoprotein90.66729.115eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
33 RBBP7suppressor80.8213.115WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
34 SIN3Aoncoprotein70.762185.988Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
35 TAZinteractor40.5003.000Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
36 TINAGL1interactor100Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
Propeptide_C1 (PF08127, IPR012599): Peptidase family C1 propeptide
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
37 TMEM25interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)

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