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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EYS, ACTR10 (from a repository: Wed Jul 24 01:08:00 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins5 (25.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)63 (33.16 %)
The number (and %) of affected PPIs18 (28.57 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI5.800
Assortativity coefficient-0.3138
The network average Clustering coefficient0.732
The number (and %) of a zero Clustering coefficients2 (10.00 %)
The number (and %) of a zero Betweenness Centrality10 (50.00 %)


List of the fusions

PPI for parental proteins: EYS,ACTR10 All fusions
Proteins found in more fusions RABEP1 (see 1 fusions); KIF11 (see 1 fusions); DCTN1 (see 2 fusions); NAGK (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 EYSinteractor000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
2 ACTR10parental protein180.261163.050Actin (PF00022, IPR004000, SM00268): Actin
3 ACTR1Ainteractor80.8571.550Actin (PF00022, IPR004000, SM00268): Actin
4 ACTR1Binteractor110.58216.383Actin (PF00022, IPR004000, SM00268): Actin
5 C9orf24interactor21.0000SMRP1 (PF15181, IPR028195): Spermatid-specific manchette-related protein 1
6 CA10interactor21.0000Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
7 CAPZA2interactor90.7783.583F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
8 CSPP1interactor60.9330.250Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
CCDC66 (PF15236): Coiled-coil domain-containing protein 66
9 DCTN1protein found in more fusions100.6679.250Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
10 DCTN2interactor120.61812.050Dynamitin (PF04912): Dynamitin
11 DCTN3interactor100.55614.967Dynactin_p22 (PF07426, IPR009991): Dynactin subunit p22
12 DCTN4interactor80.7144.667Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
13 GPS2oncoprotein30.6670.250G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
14 KIF11protein found in more fusions31.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
15 LMNB1interactor51.0000Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
16 LOC554223interactor21.0000NA
17 MYO19interactor41.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
18 NAGKprotein found in more fusions31.0000BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
19 ORC6interactor100ORC6 (PF05460, IPR008721): Origin recognition complex subunit 6 (ORC6)
20 RABEP1oncoprotein41.0000Fib_succ_major (PF09603, IPR011871): Fibrobacter succinogenes major domain (Fib_succ_major)
Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin

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