Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZC3H15, ABCB4 (from a repository: Thu Aug 22 22:40:15 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)42
The number (and %) of the onco-proteins10 (23.81 %)
The number (and %) of the tumor suppressors2 (4.76 %)
Total number of binary PPIs (saturation %)119 (13.82 %)
The number (and %) of affected PPIs40 (33.61 %)
The number of possible different fusions9
PPI diameter2
PPI radiusinf
The average degree of PPI5.048
Assortativity coefficient-0.3162
The network average Clustering coefficient0.488
The number (and %) of a zero Clustering coefficients11 (26.19 %)
The number (and %) of a zero Betweenness Centrality15 (35.71 %)


List of the fusions

PPI for parental proteins: ABCB4,ZC3H15 All fusions
Proteins found in more fusions CSNK2A1 (see 2 fusions); THOC1 (see 2 fusions); FAF1 (see 3 fusions); TNNT1 (see 1 fusions); PARK2 (see 1 fusions); DCTN1 (see 2 fusions); STAU1 (see 2 fusions); UTRN (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ABCB4parental protein202.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Dala_Dala_lig_N (PF01820, IPR011127): D-ala D-ala ligase N-terminus
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
IstB_IS21 (PF01695, IPR002611): IstB-like ATP binding protein
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
2 ZC3H15parental protein380.0941113.167zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Torus (PF16131, IPR032297): Torus domain
DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
3 ABCF2interactor40.5002.667ABC_tran (PF00005, IPR003439): ABC transporter
VIT1 (PF01988, IPR008217): VIT family
Rop (PF01815, IPR000769): Rop protein
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
4 C8orf33interactor100DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
5 CC2D2Ainteractor21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic
DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
6 CEP19interactor100CEP19 (PF14933, IPR029412): CEP19-like protein
7 CEP44interactor30.6671.000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
8 CETN2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
9 CSNK2A1oncoprotein70.5335.233Pkinase (PF00069, IPR000719): Protein kinase domain
10 DCTN1protein found in more fusions40.6671.000Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
11 DRG1interactor50.7003.000MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TGS (PF02824, IPR004095): TGS domain
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
12 FAF1protein found in more fusions40.6671.000UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
13 GINS3interactor100Sld5 (PF05916, IPR021151): GINS complex protein
14 HMGN5interactor100DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229)
HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
15 ISG15suppressor30.6670.667ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
16 KRASoncoprotein50.5002.000Ras (PF00071, IPR001806, SM00173): Ras family
17 MED4interactor40.6671.333Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
18 MRPL50interactor100Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
19 NTRK1oncoprotein130.25844.233I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 PARK2suppressor31.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
21 PHKG2interactor21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
22 PIGYinteractor100PIG-Y (PF15159, IPR029164): Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
23 PPIP5K1interactor100His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
24 PPIP5K2interactor40.5002.000His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
25 RNF2interactor100.52812.400zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
26 STAU1protein found in more fusions70.6005.167dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
27 TESK1interactor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
28 THOC1protein found in more fusions110.62211.100Death (PF00531, IPR000488, SM00005): Death domain
efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
29 THOC2interactor110.52719.767Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
30 THOC3interactor70.9520.333eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 THOC5oncoprotein100.60013.367FimP (PF09766, IPR019163): Fms-interacting protein
32 THOC6interactor90.7504.433WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
33 THOC7interactor70.7624.333EcoEI_R_C (PF08463, IPR013670): EcoEI R protein C-terminal
THOC7 (PF05615, IPR008501): Tho complex subunit 7
UPF0193 (PF05250, IPR007914): Uncharacterised protein family (UPF0193)
34 TM9SF4interactor30.6671.000EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
35 TNNT1protein found in more fusions31.0000Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
36 TRAF2interactor40.6671.000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
37 TSSK2interactor200Pkinase (PF00069, IPR000719): Protein kinase domain
38 UTRNprotein found in more fusions80.8102.500bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
39 WASF1interactor21.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
WH2 (PF02205, IPR003124, SM00246): WH2 motif
40 WDR74interactor40.5001.833WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
41 XPO1interactor90.41716.567CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
42 ZCCHC8interactor60.6672.900Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein
PSP (PF04046, IPR006568, SM00581): PSP
zf-CCHC (PF00098, IPR001878): Zinc knuckle
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)

B a c k    t o    T o p ⇑