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Fusion ID: Protein names:	55854 107984124
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Visualization interactions

Cytoscape Web for: parental proteins ZC3H15, LOC107984124 (from a repository: Thu Aug 29 08:19:25 2019)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	40
The number (and %) of the onco-proteins	10 (25.00 %)
The number (and %) of the tumor suppressors	2 (5.00 %)
Total number of binary PPIs (saturation %)	117 (15.00 %)
The number (and %) of affected PPIs	38 (32.48 %)
The number of possible different fusions	9
PPI diameter	2
PPI radius	inf
The average degree of PPI	5.200
Assortativity coefficient	-0.3625
The network average Clustering coefficient	0.512
The number (and %) of a zero Clustering coefficients	9 (22.50 %)
The number (and %) of a zero Betweenness Centrality	14 (35.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: LOC107984124,ZC3H15	All fusions
Proteins found in more fusions	CSNK2A1 (see 2 fusions); THOC1 (see 2 fusions); FAF1 (see 3 fusions); TNNT1 (see 1 fusions); PARK2 (see 1 fusions); DCTN1 (see 2 fusions); STAU1 (see 2 fusions); UTRN (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	LOC107984124	interactor	0	0	0	NA
2	ZC3H15	parental protein	38	0.094	1113.167	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus (PF16131, IPR032297): Torus domain DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
3	ABCF2	interactor	4	0.500	2.667	ABC_tran (PF00005, IPR003439): ABC transporter VIT1 (PF01988, IPR008217): VIT family Rop (PF01815, IPR000769): Rop protein ABC_tran_Xtn (PF12848, IPR032781): ABC transporter AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
4	C8orf33	interactor	1	0	0	DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
5	CC2D2A	interactor	2	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240) SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
6	CEP19	interactor	1	0	0	CEP19 (PF14933, IPR029412): CEP19-like protein
7	CEP44	interactor	3	0.667	1.000	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Utp12 (PF04003, IPR007148): Dip2/Utp12 Family CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
8	CETN2	interactor	1	0	0	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
9	CSNK2A1	oncoprotein	7	0.533	5.233	Pkinase (PF00069, IPR000719): Protein kinase domain
10	DCTN1	protein found in more fusions	4	0.667	1.000	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain FlgN (PF05130, IPR007809): FlgN protein HOOK (PF05622, IPR008636): HOOK protein SlyX (PF04102, IPR007236): SlyX TSC22 (PF01166, IPR000580): TSC-22/dip/bun family DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443) ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Dynactin (PF12455, IPR022157): Dynein associated protein Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
11	DRG1	interactor	5	0.700	3.000	MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase TGS (PF02824, IPR004095): TGS domain MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
12	FAF1	protein found in more fusions	4	0.667	1.000	UBX (PF00789, IPR001012, SM00166): UBX domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family AAA_11 (PF13086): AAA domain UBA_4 (PF14555): UBA-like domain
13	GINS3	interactor	1	0	0	Sld5 (PF05916, IPR021151): GINS complex protein
14	HMGN5	interactor	1	0	0	DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229) HMG14_17 (PF01101, IPR000079, SM00527): HMG14 and HMG17
15	ISG15	suppressor	3	0.667	0.667	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
16	KRAS	oncoprotein	5	0.500	2.000	Ras (PF00071, IPR001806, SM00173): Ras family
17	MED4	interactor	4	0.667	1.333	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
18	MRPL50	interactor	1	0	0	Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
19	NTRK1	oncoprotein	13	0.258	44.233	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20	PARK2	suppressor	3	1.000	0	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
21	PHKG2	interactor	2	1.000	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
22	PPIP5K1	interactor	1	0	0	His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2) RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
23	PPIP5K2	interactor	4	0.500	2.000	His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2) RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
24	RNF2	interactor	10	0.528	12.400	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
25	STAU1	protein found in more fusions	7	0.600	5.167	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
26	THOC1	protein found in more fusions	11	0.622	11.100	Death (PF00531, IPR000488, SM00005): Death domain efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
27	THOC2	interactor	11	0.527	19.767	Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
28	THOC3	interactor	7	0.952	0.333	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
29	THOC5	oncoprotein	10	0.600	13.367	FimP (PF09766, IPR019163): Fms-interacting protein
30	THOC6	interactor	9	0.750	4.433	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
31	THOC7	interactor	7	0.762	4.333	EcoEI_R_C (PF08463, IPR013670): EcoEI R protein C-terminal THOC7 (PF05615, IPR008501): Tho complex subunit 7 UPF0193 (PF05250, IPR007914): Uncharacterised protein family (UPF0193)
32	TM9SF4	interactor	3	0.667	1.000	EMP70 (PF02990, IPR004240): Endomembrane protein 70 DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
33	TNNT1	protein found in more fusions	3	1.000	0	Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
34	TRAF2	interactor	4	0.667	1.000	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
35	TSSK2	interactor	2	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain
36	UTRN	protein found in more fusions	8	0.810	2.500	bZIP_1 (PF00170, IPR004827): bZIP transcription factor CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 EF-hand_2 (PF09068, IPR015153): EF hand EF-hand_3 (PF09069, IPR015154): EF-hand Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Spectrin (PF00435, IPR002017): Spectrin repeat TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein WW (PF00397, IPR001202, SM00456): WW domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
37	WASF1	interactor	2	1.000	0	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator WH2 (PF02205, IPR003124, SM00246): WH2 motif
38	WDR74	interactor	4	0.500	1.833	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
39	XPO1	interactor	9	0.417	16.567	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
40	ZCCHC8	interactor	6	0.667	2.900	Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein PSP (PF04046, IPR006568, SM00581): PSP zf-CCHC (PF00098, IPR001878): Zinc knuckle DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)

B a c k t o T o p ⇑

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Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors