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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COX3, WDR12 (from a repository: Thu Aug 15 18:24:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)69
The number (and %) of the onco-proteins11 (15.94 %)
The number (and %) of the tumor suppressors4 (5.80 %)
Total number of binary PPIs (saturation %)288 (12.28 %)
The number (and %) of affected PPIs68 (23.61 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI7.826
Assortativity coefficient-0.1958
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients11 (15.94 %)
The number (and %) of a zero Betweenness Centrality13 (18.84 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COX3,WDR12 All fusions
Proteins found in more fusions GRK5 (see 2 fusions); TSN (see 1 fusions); BOP1 (see 1 fusions); TSG101 (see 2 fusions); RAC1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COX3parental protein50280.333NA
2 WDR12parental protein630.1042983.314NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
3 ACBD3interactor50.7003.050ACBP (PF00887, IPR000582): Acyl CoA binding protein
CDC45 (PF02724, IPR003874): CDC45-like protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
NINJA_B (PF16136, IPR032310): Putative nuclear localisation signal
4 BMI1oncoprotein100.36117.086zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
5 BOP1oncoprotein110.46717.382BOP1NT (PF08145, IPR012953, SM01035): BOP1NT (NUC169) domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3038 (PF11237, IPR021399): Protein of unknown function (DUF3038)
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 BRIX1interactor150.629124.699Brix (PF04427, IPR007109, SM00879): Brix domain
7 BTRConcoprotein80.38159.524WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
8 BYSLinteractor70.5714.610Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
9 CASQ2interactor31.0000Calsequestrin (PF01216, IPR001393): Calsequestrin
SDA1 (PF05285, IPR007949): SDA1
10 CHMP7interactor40.8330.667Snf7 (PF03357, IPR005024): Snf7
11 CNTRLoncoprotein100APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
12 CSNK2Binteractor70.5333.119CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
13 DDX19Ainteractor40.500135.581DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
14 DDX24interactor160.67520.550DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 DDX27interactor90.8331.443Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
16 DDX54interactor40.8330.143DBP10CT (PF08147, IPR012541, SM01123): DBP10CT (NUC160) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17 DDX6oncoprotein31.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18 EBNA1BP2interactor120.8332.497Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
19 FBXW11interactor80.38113.302WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
20 FTSJ3interactor140.67013.200DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein
Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
21 GRK5protein found in more fusions60.6001.348Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
22 GTPBP4suppressor120.7586.730DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MRC1 (PF09444, IPR018564): MRC1-like domain
NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1)
NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain
Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus
AAA_16 (PF13191): AAA ATPase domain
23 HIST1H1Concoprotein40.6672.000Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
24 HNRNPDLinteractor40.6671.667CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
25 HSPB2interactor200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
26 IFI16suppressor180.37370.762HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
27 INPP1interactor100Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
28 KMT2Einteractor30.33322.651CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
29 KRASoncoprotein70348.276Ras (PF00071, IPR001806, SM00173): Ras family
30 LIG4interactor2022.914APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
31 MDN1interactor50.7001.733AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
DnaB_C (PF03796, IPR007694): DnaB-like helicase C terminal domain
AAA_16 (PF13191): AAA ATPase domain
Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
32 MRTO4interactor140.61518.419Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
33 NIFKinteractor150.71411.998RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
34 NOC3Linteractor90.8061.315CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
DsrD (PF08679, IPR014793): Dissimilatory sulfite reductase D (DsrD)
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
NOC3p (PF07540, IPR011501): Nucleolar complex-associated protein
Scm3 (PF10384, IPR018465): Centromere protein Scm3
35 PES1interactor180.64024.116Pescadillo_N (PF06732, IPR010613): Pescadillo N-terminus
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
36 PPP2CBsuppressor21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
37 PPP3CBinteractor50.7002.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
38 PSPC1interactor30.6670.500FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Zot (PF05707, IPR008900): Zonular occludens toxin (Zot)
39 PUS1interactor40.6672.000PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
40 RAC1oncoprotein3023.209Ras (PF00071, IPR001806, SM00173): Ras family
41 RNF2interactor220.32996.082zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
42 RPL36interactor60.7332.200Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
43 RPL4interactor140.60418.607Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
44 RPL7interactor110.6918.156Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
45 RPUSD2interactor40.8331.222PseudoU_synth_2 (PF00849, IPR006145): RNA pseudouridylate synthase
46 RTCBinteractor60.4675.286RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
47 SEPHS1interactor70.5339.733AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
48 SIRT7interactor210.38680.703DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
49 SNF8interactor70.6004.167EAP30 (PF04157, IPR007286): EAP30/Vps36 family
50 SRSF5interactor50.6004.845DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
51 SUGT1interactor21.0000CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
52 TBC1D13interactor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
53 TBCDinteractor90.27896.366HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
54 TOM1oncoprotein50.400138.543GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
55 TOMM34interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
DUF4919 (PF16266, IPR032578): Domain of unknown function (DUF4919)
56 TSG101suppressor90.42920.012APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
57 TSNprotein found in more fusions41.0000Translin (PF01997, IPR002848): Translin family
58 TUFMinteractor90.41714.096GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
59 TXN2interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
60 UBE2Zinteractor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
61 USP14interactor40.8330.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
62 VAT1interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
63 VPS25interactor90.46415.084ESCRT-II (PF05871, IPR008570): ESCRT-II complex subunit
64 VPS29interactor60.6006.012Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
65 VPS36interactor90.46411.833EAP30 (PF04157, IPR007286): EAP30/Vps36 family
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
66 VPS37Binteractor50.7002.000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
67 WDR5interactor60.6004.286WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
68 WDR92interactor40.6672.517WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
69 XPO1interactor220.186333.448CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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